Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

Author(s): Vijayakrishnan J,  Studd J,  Broderick P,  Kinnersley B,  Holroyd A,  Law PJ,  Kumar R,  Allan JM,  Harrison CJ,  Moorman AV,  Vora A,  Roman E,  Rachakonda S,  Kinsey SE,  Sheridan E,  Thompson PD,  Irving JA,  Koehler R,  Hoffmann P,  Nöthen MM,  Heilmann-Heimbach S,  Jöckel KH,  Easton DF,  Pharaoh PDP,  Dunning AM,  Peto J,  Canzian F,  Swerdlow A,  Eeles RA,  Kote-Jarai Z,  Muir K,  Pashayan N,  PRACTICAL Consortium,  Greaves M,  Zimmerman M,  Bartram CR,  Schrappe M,  Stanulla M,  Hemminki K,  Houlston RS

Journal: Nat Commun

Date: 2018 Apr 9

Major Program(s) or Research Group(s): PLCO

PubMed ID: 29632299

PMC ID: PMC5890276

Abstract: Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.