Right-sided ectocervical lesions may be associated with false-negative cytology among women with histologic cervical intraepithelial neoplasia 2 or 3.

Author(s): Jeronimo J,  Castle PE,  Herrero R,  Sherman ME,  Bratti MC,  Hildesheim A,  Alfaro M,  Morales J,  Hutchinson ML,  Burk RD,  Lorincz A,  Wacholder S,  Rodríguez AC,  Schiffman M

Journal: J Low Genit Tract Dis

Date: 2003 Jul

Major Program(s) or Research Group(s): BGCRG, OD

PubMed ID: 17051065

PMC ID: not available

Abstract: BACKGROUND: The association between the location of an ectocervical lesion and the sensibility of cytologic screening has not been adequately evaluated. METHODS: We evaluated the proportion of false-negative cytologic interpretations using three independent cytologic interpretations (conventional, PapNet, and ThinPrep) according to lesion location in 111 women with histologic cervical intraepithelial neoplasia 2 or 3 of a population-based study of cervical neoplasia conducted in Guanacaste, Costa Rica. Semiquantitative measures of human papillomavirus viral load were also considered. RESULTS: Lesions on a women's right ectocervix were associated with more frequent false-negative results than lesions on left ectocervix for each of the cytologic methods or when the most severe interpretation was considered (p = .004). Right-sided lesions had nonsignificantly lower viral loads than left-sided lesions (p = .2). CONCLUSIONS: Cervical intraepithelial neoplasia 2 or 3 located on the right side of the cervix may be poorly sampled with broom samplers in some settings, resulting in false-negative cytologic results.