Publications

Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.

Author(s): Hart PA,  Andersen DK,  Mather KJ,  Castonguay AC,  Bajaj M,  Bellin MD,  Bradley D,  Contreras N,  Habtezion A,  Korc M,  Kudva Y,  Petrov MS,  Whitcomb DC,  Yadav D,  Yuan Y,  Rinaudo JAS,  Srivastava S,  Serrano J,  Goodarzi MO,  Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)

Journal: Pancreas

Date: 2018 Nov-Dec

Major Program(s) or Research Group(s): CBRG

PubMed ID: 30325863

PMC ID: PMC6195331

Abstract: Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, "Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study," that seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions after a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.