HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study.

Author(s): Zhang HY,  Tiggelaar SM,  Sahasrabuddhe VV,  Smith JS,  Jiang CQ,  Mei RB,  Wang XG,  Li ZA,  Qiao YL

Journal: Asian Pac J Cancer Prev

Date: 2012

Major Program(s) or Research Group(s): BGCRG

PubMed ID: 22502720

PMC ID: PMC3809115

Abstract: OBJECTIVES: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China. METHODS: Cervical cytology, HPV detection by Hybrid Capture-2™ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters. RESULTS: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with <CIN1 after adjusting for age (OR: 8.3, 95% CI: 0.9, 73.4). Women with CD4+ cell counts less than 350 cells/μL had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5). CONCLUSIONS: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.