Selenoproteins Harboring a Split Personality in Both Preventing and Promoting Cancer.

Author(s): Yoo M-H,  Carlson BA,  Tsuji PA,  Tobe R,  Naranjo-Suarez S,  Lee BJ,  Davis CD,  Gladyshev VN,  Hatfield DL


Date: 2012

Major Program(s) or Research Group(s): CPFP

PubMed ID:

PMC ID: not available

Abstract: Selenium has long been known to have a role in preventing cancer, but only in recent years has a deficiency in this element also been shown to function in preventing cancer. Selenoproteins have also been shown to serve as selenium-containing components in cancer prevention, but we are learning that specific members of this protein class can also function in cancer promotion. The involvement of two of these selenoproteins, thioredoxin reductase 1 and the 15 kDa selenoprotein, in promoting cancer is examined in this chapter.