PLCO: Evolution of an Epidemiologic Resource and Opportunities for Future Studies.

Author(s): Black A,  Huang WY,  Wright P,  Riley T,  Mabie J,  Mathew S,  Ragard L,  Hermansen S,  Yu K,  Pinsky P,  Prorok PC,  Freedman ND,  Hoover RN

Journal: Rev Recent Clin Trials

Date: 2015

Major Program(s) or Research Group(s): BRG, EDRG, OD, PLCO

PubMed ID: 26435289

PMC ID: PMC6444921

Abstract: The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO), a large-scale, multi-institutional, randomized controlled trial, was launched in 1992 to evaluate the effectiveness of screening modalities for prostate, lung, colorectal, and ovarian cancer. However, PLCO was additionally designed to serve as an epidemiologic resource and the National Cancer Institute has invested substantial resources over the years to accomplish this goal. In this report, we provide a summary of changes to PLCO's follow-up after conclusion of the screening phase of the trial and highlight recent data and biospecimen collections, including ancillary studies, geocoding, administration of a new medication use questionnaire, consent for linkage to Medicare, and additional tissue collection that enhance the richness of the PLCO resource and provide further opportunities for scientific investigation into the prevention, early detection, etiology and treatment of cancer.