Systems biology and cancer: promises and perils.

Author(s): Baker SG,  Kramer BS

Journal: Prog Biophys Mol Biol

Date: 2011 Aug

Major Program(s) or Research Group(s): BRG

PubMed ID: 21419159

PMC ID: PMC3156977

Abstract: Systems biology uses systems of mathematical rules and formulas to study complex biological phenomena. In cancer research there are three distinct threads in systems biology research: modeling biology or biophysics with the goal of establishing plausibility or obtaining insights, modeling based on statistics, bioinformatics, and reverse engineering with the goal of better characterizing the system, and modeling with the goal of clinical predictions. Using illustrative examples we discuss these threads in the context of cancer research.