Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink.

Author(s): Yang B,  Hagberg KW,  Chen J,  Sahasrabuddhe VV,  Graubard BI,  Jick S,  McGlynn KA

Journal: Br J Cancer

Date: 2016 Jun 28

Major Program(s) or Research Group(s): BGCRG

PubMed ID: 27219020

PMC ID: PMC4931369

Abstract: BACKGROUND: Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS: We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtained from prescription records. Multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression. RESULTS: Ever-use of prescription antibiotics was associated with a slightly increased risk of liver cancer, compared to non-use (OR=1.22, 95% CI=1.03-1.45). However, there was no clear dose-response relationship by the number of prescriptions or cumulative dose of antibiotic use, suggesting a non-causal association. CONCLUSIONS: Our results do not support a role of antibiotic use in liver cancer development.