Dr. Christos Patriotis obtained his M.Sc. in Biochemistry from the University of Sofia, Bulgaria in 1985 and his Ph.D. in Molecular Biology from the Bulgarian Academy of Sciences in 1990. Postdoctoral training focused on signal transduction and tumor cell biology. He joined the faculty at Fox Chase Cancer Center in 1998; his research was directed toward understanding mechanisms of breast and ovarian cancer pathogenesis and identification of biomarkers associated with the early stages of the two types of cancer. This included development and characterization of animal models of breast and ovarian cancers, and high throughput microarray-based analysis of specimens obtained from human and animal models for biomarker discovery.
He joined the Cancer Biomarkers Research Group in March, 2007. He is involved in management and coordination of Cooperative Agreement awards of the Early Detection Research Network focused on breast, ovarian and other gynecological cancers. He provides leadership and direction of large, multi-center clinical validation studies of biomarkers for the early detection and prognosis of cancer. He directs the development of the EDRN Knowledge Environment to facilitate biomarker research within and outside the Network. This represents an integrated system of multiple data bases and informatics tools, which is being developed by the EDRN Informatics Center at NASA's Jet Propulsion Laboratory. EKE is based on a repository of Common Data Elements combined with the Object Oriented Data Technology middleware software developed at JPL. EDRN bioinformatics infrastructure enables interoperability among biomarker research groups, computing systems and distributed databases of biospecimens and biomarker data.