Projects and Investigators

FY 2003 Projects

Johns Hopkins University School of Medicine

Objective

Development of the Glucosinolate of Sulforaphane (Glucoraphanin) to Prevent Familial Adenomatous Polyposis, a Precursor of Colon Cancer, and to Eradicate Helicobacter pylori Infections, a Risk Factor for Gastric Cancer.

Program Description

Investigators will conduct preclinical development of the Glucosinolate of Sulforaphane (Glucoraphanin). Glucosinolates (e.g. glucoraphanin) are stable precursors of isothiocyanates and are naturally occurring substances found in cruciferous vegetables. Glucoraphanin and sulforaphane have been isolated from broccoli and its seeds and sprouts and demonstrated to possess significant anticarcinogenic activity, probably mediated by the induction of Phase 2 drug metabolism enzymes. In addition, they also exhibit strong bactericidal activity against intracellular, extracellular and antibiotic resistant H. pylori. RAPID support will include:

• Process development and scale-up production of high purity glucoraphanin,
• In vivo preclinical efficacy studies, and
• Preclinical toxicology studies.

Contact Information

Dr. Paul Talalay
Johns Hopkins University School of Medicine
Baltimore, MD
Tel: 410-955-3499
Fax: 410-502-6818
E-mail: ptalalay@jhmi.edu