Projects and Investigators

FY 2003 Projects

Dartmouth Medical School

Objective

Bulk Synthesis of the New Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) for Making New Derivatives with Improved Pharmacokinetics.

Program Description

Investigators will conduct preclinical development of several synthetic triterpenoid derivatives of CDDO. Several new synthetic triterpenoid derivatives of CDDO have exhibited activity in various chemopreventive and chemotherapeutic cell culture models. However, these promising pharmacodynamic properties are limited in vivo by suboptimal pharmacokinetic characteristics of these compounds. CDDO will be used as a starting material for new derivatives with improved pharmacokinetic profiles. RAPID support will include bulk synthesis of 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).

Contact Information

Dr. Michael B. Sporn
Dartmouth Medical School
Dartmouth, NH
Tel: 603-650-6557
Fax: 603-650-1129
E-mail: Michael.B.Sporn@Dartmouth.edu

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