skip to content National Cancer Institute U.S. National Institutes of Health www.cancer.gov
Division of Cancer Prevention logo
Home Site Map Contact DCP
Skip to subnavigation.
Programs & Resources
skip sub-navigation, go to content.

Rapid Access to Preventive Intervention Development (RAPID) Program

Projects and Investigators

FY 2001 Projects

Dartmouth Medical School

Objective

Bulk synthesis of the new triterpenoids, 2-Carboxy-DDO methyl ester and its homolog, 2-Carboxy-DDO ethyl ester.

Program Description

Investigators will conduct preclinical development of the new triterpenoids, 2-Carboxy-DDO methyl ester and its homolog, 2-Carboxy-DDO ethyl ester. These 2 new triterpenoids were synthesized to obviate some of the in vivo limitations of their predecessors, namely poor pharmacokinetic profile. Preliminary data suggest that these compounds have numerous activities in cell culture (including inhibition of inducible nitric oxide synthetase and cyclooxygenase-2 and binding to PPAR-g receptor) and in vivo that are relevant to prevention of human cancer. RAPID support will include bulk synthesis of these compounds.

Contact Information

Michael B. Sporn
Dartmouth Medical School
Dartmouth, NH
Tel: 603-650-6557
Fax: 603-650-1129
E-mail: Micahel.B.Sporn@Dartmouth.edu

View investigator's other projects