Projects and Investigators

FY 2001 Projects

University of Illinois at Chicago

Objective

Preclinical development of four flavonoids from Broussonetia Papyrifera.

Program Description

Investigators will conduct preclinical development of four flavonoids from Broussonetia papyrifera. Bioassay-guided fractionation of an extract from Broussonetia papyrifera, an endemic edible plant, using an in vitro aromatase inhibition assay led to isolation of four active flavonoid compounds. Preliminary results suggest that these compounds may be effective chemopreventive agents in preventing formation of estrogen-dependent tumors in the breast and the prostate. RAPID support will include:

• Synthesis of bulk materials for preclinical studies,
• Mutagenicity and short term preclinical toxicity testing, and
• In vivo screening and efficacy studies.

Contact Information

Dr. John M. Pezzuto
Purdue University
West Lafayette, IN
Tel: 765-494-1368
Fax: 765-494-7880
E-mail: jpezzuto@purdue.edu

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