Projects and Investigators

FY 2003 Projects

Kanazawa University, Japan

Objective

Scale Up Production of a Potent Chemopreventive Agent, 1SY16 for Preclinical and Clinical Studies.

Program Description

Investigators will conduct preclinical development of a Potent Chemopreventive Agent, 1SY16. Preliminary studies have shown that mycochemicals extracted from mushrooms may possess both immunostimulating and antiproliferative properties, and a potent chemopreventive activity in animal models. 1SY16, an extract of Agaricus Blazei Murill, is a mixture of low molecular weight compounds with promising chemopreventive activities. RAPID support will include:

• Production scale up for 1SY16,
• In vivo preclinical efficacy studies, preclinical genotoxicity, and
• Subacute animal toxicity studies.

Contact Information

Dr. Insu P. Lee
Kanazawa University
Japan
Tel: 81-90-372-45628
E-mail: iplee0823@aol.com