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Rapid Access to Preventive Intervention Development (RAPID) Program

Projects and Investigators

FY 2003 Projects

University of Texas at Austin

Objective

Development of a-TEA, a Novel Tocopherol Based Anticancer Agent, for Prevention of Breast Cancer Recurrence and Metastasis

Program Description

Investigators will conduct preclinical development of a-TEA (2,5,7,8-tetramethyl-2R-(4R', 8R', 12'-trimethyltridecyl)chroman-6-yloxy) acetic acid a novel synthetic derivative of naturally occurring vitamin E (RRR-a-tocopherol). Preliminary studies in mouse mammary cancer models showed that this compound can inhibit tumor growth and metastasis without toxicity. It was proposed that it may be effective in preventing breast cancer recurrence and spread. The initial RAPID support will include:

  • Scale up non-GMP synthesis of a-TEA,
  • In vivo preclinical efficacy studies, and
  • Preclinical genotoxicity studies.

Contact Information

Drs. Kimberly Kline and Bob G. Sanders
University of Texas at Austin
Austin, TX
Tel: 512-471-8911 (KK)
Tel: 512-471-7441 (BGS)
Fax: 512-232-7040 (KK)
512-232-7040 (BGS)
E-mail: k.kline@mail.utexas.edu