Projects and Investigators

FY 2001 Projects

Johns Hopkins University Bloomberg School of Hygiene and Public Health

Objective

Development of a novel, non-calcemic, hybrid deltanoid QW-1624F2-2. Preclinical development of 5,6-dihydro-4H-cyclopenta-1,2-dithiole-3-thione, a selective phase II enzyme inducer for cancer prevention.

Program Description

Synthetic deltanoids (vitamin analogs) exhibit in vivo and in vitro evidence of antiproliferative, proapoptotic, prodifferentiating, and antiangiogenic activities indicative of chemopreventive efficacy. One such analog, QW-1624F2-2 possesses a substantially improved chemopreventive index in terms of its chemopreventive efficacy vs. calcemic toxicity. Preliminary results have shown that it is a potent, effective inhibitor of carcinogenesis in vivo. RAPID support will include synthesis of bulk material for preclinical studies, mutagenicity and short term preclinical toxicity testing, and in vivo screening and efficacy studies.

Contact Information

Thomas W. Kensler
Johns Hopkins University Bloomberg School of Hygiene and Public Health
Baltimore, MD
Tel: 410-955-4712
Fax: 410-955-0116
E-mail: tkensler@jhsph.edu

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