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Rapid Access to Preventive Intervention Development (RAPID) Program

Projects and Investigators

FY 2003 Projects

SRI International

Objective

SR13668: A Novel Dietary Indole Analog for Cancer Prevention.

Program Description

Investigators will conduct preclinical development of SR13668, a new synthetic analog of naturally occurring indole-3-carbinol (I3C). I3C is found in cruciferous vegetables (broccoli, cabbage etc.) and exhibits several chemopreventive activities. SR13668 is a result of lead-based rational drug design using computational modeling to optimize chemopreventive I3C activities and minimize its undesirable characteristics. RAPID support will include:

  • Scale up non-GMP synthesis of SR13668 for preclinical studies,
  • In vivo preclinical efficacy studies,
  • Preclinical toxicology studies, and
  • Preclinical pharmacokinetic studies.

Contact Information

Dr. Ling Jong
SRI International
Tel: 650-859-6121
Fax: 650-859-3153
E-mail: ling.jong@sri.com