Projects and Investigators

FY 2003 Projects

Dr. Denis E. Corpet

Objective

Chemoprevention of Colorectal Tumors by Dietary Polyethylene Glycol (PEG).

Program Description

Investigators will conduct preclinical development of Dietary Polyethylene Glycol (PEG). Water-soluble, high molecular weight polymeric polyethylene glycols are used as food additives and gentle laxatives. They are not absorbed from the gastro-intestinal tract and nor are they metabolized by gut microflora. They possess low toxicity and have recently showed chemopreventive activity in carcinogen-induced colon cancer in rats. Supporting scientific documentation will be presented for consideration of a phase 1/2 clinical study with modulation of aberrant crypt foci as the primary endpoint.

Contact Information

Dr. Denis E. Corpet
Tel: 33-561-1939-82
Fax: 33-561-491-263
E-mail: d.corpet@envt.fr