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Programs & Resources

PREVENT Cancer Preclinical Drug Development Program

Funded Projects

Breast Cancer (vaccines)

  • Plac1 vaccine for breast cancer prevention
  • Efficacy of a multi-antigen vaccine in the prevention of methynitrosourea-induced mammary cancers (ER+) in female Sprague-Dawley rats

Breast Cancer (small molecules and biomarkers)

  • Chemopreventive effects in both standard chow diets and high-fat diets of known positive- and negative-chemopreventive agents employing both high-risk (but histologically normal) mammary epithelium and mammary cancers including correlative biomarkers
  • Blood-based markers of obesity-induced breast inflammation
  • Efficacy of metformin in the methylnitrosourea-induced model of ER+ mammary carcinogenesis when animals are placed on different diets: standard diet, high fat diet, and high fructose diet
  • Evaluation of GLG-302, a STAT3 antagonist, in the prevention of mammary cancer

Cervical Cancer (small molecule)

  • Nonclinical safety, toxicokinetic, and stability evaluation of BioResponse diindolylmethane vaginal cream for topical treatment of cervical intraepithelial neoplasia

Colon Cancer (small molecules)

  • Preclinical development of mPGES-1 and 5-LOX selective inhibitors for colon cancer chemoprevention
  • Combination of aspirin and omeprazole for colon cancer chemoprevention
  • Efficacy of aspirin and naproxen (short-term frequent dosing) in colorectal cancer models
  • Efficacy of eldecalcitol (ED-71) in colorectal cancer prevention in the Apc-Min mouse model
  • NSAID chemoprevention in colon cancer

Colon Cancer (vaccine)

  • Characterization of potential antigens for immunization against colon cancer and testing multivalent tumor vaccines in min mice

Colon Cancer (biomarker)

  • Effect of a chemopreventive agent on the fecal metabolite profile in intestinal neoplasia

Lung Cancer (small molecules)

  • In vivo evaluation of a chemopreventive agent, Ciclesonide, in mouse lung tumor model by inhalation
  • Anti-inflammatory effects of fixed-dose combinations of pioglitazone and metformin for lung cancer prevention
  • Effects of weekly or intermittent dosing regimens of EGFR, MEK, and PI3K inhibitiors in mouse models of lung cancer

Lung Cancer (vaccine)

  • Use of TERT peptide vaccine in prevention of lung cancer in animal models

Lung Cancer (biomarker)

  • Modulation of cigarette smoke-induced alterations of microRNA expression and lung tumors in mice treated with aspirin and naproxen
  • Effects of chemopreventive agents on biomarkers related to lung tumorigenesis: Alterations in normal lung, at risk lung and lesions

Pancreatic Cancer (vaccine)

  • Development of Muc1 vaccine for prevention of pancreatic cancer

Pancreatic Cancer (small molecule)

  • Targeting P2X7 receptor for prevention of pancreatic cancer

Prostate Cancer (small molecule)

  • Prostate cancer chemoprevention by estrogen receptor beta agonists

Oral Cancer (small molecule)

  • Oral cancer chemoprevention by inhibitors of inducible nitric oxide synthase

Skin Cancer (small molecule)

  • Preclinical studies to repurpose itraconazole for topical treatment of basal cell carcinoma

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