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Extraordinary Opportunities for Early Cancer Detection and Risk Assessment Research

Cooperative Family Registry for Epidemiologic Studies of Colon Cancer

RFA-CA-96-011, Jointly sponsored with Division of Cancer Control and Population Sciences, Division of Cancer Epidemiology and Genetics, and Extramural Programs Branch, Division of Cancer Prevention.

Colorectal cancer is the third most common malignancy in the world, and mortality from it has changed very little in the last 50 years. However, early detection is one of the most important factors for a good prognosis. It is estimated that approximately 10 to 15 percent of colorectal cancer is familial, and that one person in 200 may carry high-risk alleles of the genes causing inherited colorectal cancer. It is also estimated that the same genes may be involved in as much as 13 percent of sporadic tumors. The initiative is facilitatinig the translational research process for the application of predictive testing for colorectal cancer susceptibility in high-risk populations the design of effective prevention and therapeutic approaches.

The purpose of the proposed awards is to stimulate a cooperative effort to: 1) collect pedigree information, epidemiological data and related biological specimens from patients with a family history of colon cancer in order to provide a registry resource for interdisciplinary studies on the etiology of colon cancer, and to encourage translational research in this area; and 2) identify a population at high risk for colon cancer that could benefit from new preventive and therapeutic strategies.

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