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Chemopreventive Agent Development Research Group

Publications

View All  |  2014-2010  |  2009-2000  |  1999-1990  |  1989-1985

  • Arbeit JM, Riley RR, Huey B, Porter C, Kelloff G, Lubet R, Ward JM, Pinkel D. (1999) Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice. Cancer Res 59(15):3610-20.
  • Bacus JW, Boone CW, Bacus JV, Follen M, Kelloff GJ, Kagan V, Lippman SM. (1999) Image morphometric nuclear grading of intraepithelial neoplastic lesions with applications to cancer chemoprevention trials. Cancer Epidemiol Biomarkers Prev 8(12):1087-94.
  • Bednarek A; Shilkaitis A; Green A; Lubet R; Kelloff G; Christov K; Aldaz CM (1999) Suppression of cell proliferation and telomerase activity in 4-(hydroxyphenyl)retinamide-treated mammary tumors. Carcinogenesis 20:879-83.
  • Brown AP, Morrissey RL, Crowell JA, Levine BS. (1999) Thirteen-week oral toxicity study of difluoromethylornithine in combination with tamoxifen citrate in female dogs. Cancer Chemother Pharmacol. 43(6):479-88.
  • Brown AP, Morrissey RL, Crowell JA, Levine BS. (1999) Difluoromethylornithine in combination with tamoxifen in female rats: 13-week oral toxicity study. Cancer Chemother Pharmacol. 44(6):475-83.
  • Cohen LA, Zhao Z, Pittman B, Lubet, R. (1999) S-allylcysteine, a garlic constituent, fails to inhibit N-methylnitrosourea-induced rat mammary tumorigenesis. Nutr Cancer 35(1):58-63.
  • Cronin KA, Freedman LS, Lieberman R, Weiss HL, Beenken SW, Kelloff GJ. (1999) Bayesian monitoring of phase II trials in cancer chemoprevention. J Clin Epidemiol 2(8):705-11.
  • Elmore, E.E., Sun, C., Li, H-R., Wyatt, G.P., Buckmeier, J.A., Steele, V.E., Kelloff, G.J., and Redpath, L. (1999) In vitro chemopreventive efficacy screening using human keratinocytes and the in vivo data correlation. Anticancer Res. 19:909-918.
  • Fischer SM, Lo HH, Gordon GB, Seibert K, Kelloff G, Lubet RA, Conti CJ. (1999) Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol Carcinog 25(4):231-40.
  • Haag JD; Brasic GM; Shepel LA; Newton MA; Grubbs CJ; Lubet RA; Kelloff GJ; Gould MN (1999) A comparative analysis of allelic imbalance events in chemically induced rat mammary, colon, and bladder tumors. Mol Carcinog 24:47-56.
  • Hawk E, Lubet R, Limburg, P (1999) Chemoprevention in hereditary colorectal cancer syndromes. Cancer 86(8 Suppl):1731-43.
  • Hawk E, Lubet R, Limburg P (1999) Chemoprevention in hereditary colorectal cancer syndromes. Cancer 86(11 Suppl):2551-63.
  • Izzotti A, Bagnasco M, D'Agostini F, Cartiglia C, Lubet RA, Kelloff GJ, De Flora S. (1999) Formation and persistence of nucleotide alterations in rats exposed whole-body to environmental cigarette smoke. Carcinogenesis 20(8):1499-506.
  • Izzotti A, Camoirano A, Cartiglia C, Grubbs C, Lubet R, Kelloff G, and DeFlora S. (1999) Patterns of DNA adduct formation in liver and mammary epithelial cells of rats treated with 7,12-dimethylbenz(a)anthracene, and selective effects of chemopreventive agents. Cancer Res. 59:4285-4290.
  • Kawamori T, Lubet R, Steele VE, Kelloff GJ, Kaskey RB, Rao C, and Reddy BS. (1999) Chemopreventive effect of curcumin, a naturally-occurring antiinflammatory agent during the promotion/progression stages of colon cancer. Cancer Res., 59:597-601.
  • Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Boone CW, Malone WA, Hawk ET, Lieberman R, Lawrence JA, Kopelovich L, Ali I, Viner JL, Sigman CC. (1999) Progress in cancer chemoprevention. Ann N Y Acad Sci. 889:1-13. Review.
  • Kelloff, GJ, Lieberman, R, Steele, VE, Boone, CW, Lubet, RA, Kopelovich, L, Malone, WA, Crowell, JA, Sigman, CC. (1999) Chemoprevention of prostate cancer: concepts and strategies. Eur. Urol 35:342-350.
  • Kelloff GJ, Sigman CC, Greenwald P. (1999) Cancer chemoprevention: progress and promise. Eur J Cancer. Dec;35(13):1755-62. Review.
  • Kirchner DL, Mercieca MD, Crowell JA, Levine BS. (1999) Developmental toxicity studies of 2-(difluoromethyl)-dl-ornithine (DFMO) in rats and rabbits. Toxicol Sci. Jul;50(1):127-35.
  • Kopelovich L, Henson DE, Gazdar AF, Dunn B, Srivastava S, Kelloff GJ, Greenwald P. (1999) Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect. Clin Cancer Res 5(12):3899-905.
  • Lam S, leRiche JC, Zheng Y; Coldman A; MacAulay C; Hawk E; Kelloff G; Gazdar AF (1999) Sex-related differences in bronchial epithelial changes associated with tobacco smoking. J Natl Cancer Inst 91:691-6.
  • Lantry LE; Zhang Z; Crist KA; Wang Y; Kelloff GJ; Lubet RA; You M (1999) 5-Aza-2'- deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1- (3-pyridyl)-1-butanone-induced primary mouse lung tumor model. Carcinogenesis 20:343-6.
  • Lee, S.K., Song, L., Mata-Greenwood, E., Kelloff, G.J., Steele, V.E., and J.M. Pezzuto (1999) Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. Anticancer Res. 19:35-44.
  • Li H, Kramer PM, Lubet RA, Steele VE, Kelloff GJ, Pereira MA (1999) Termination of piroxicam treatment and the occurrence of azoxymethane-induced colon cancer in rats. Cancer Lett 147(1-2):187-93.
  • Li, H., Schut, H.A.J., Conran, P., Kramer, P.M., Lubet, R.A., Steele, V.E., Hawk, E.E., Kelloff, G.J., and Pereira, M.A. (1999) Prevention by aspirin and its combination with -difluoromethylornithine of azoxymethane-induced tumors, aberrant crypt foci and prostaglandin E2 levels in rat colon. Carcinogenesis 20(3):425-430.
  • McCaskill-Stevens W, Hawk ET, Flynn PJ, Lippman SM (1999) National Cancer Institute--supported cancer chemoprevention research:coming of age. J Clin Oncol 1999 Nov;17(11 Suppl):53-62.
  • McCormick, D.L., Rao, K.V.N., Steele, V.E., Lubet, R.A., Kelloff, G.J., and Bosland M.C. (1999) Chemoprevention of rat prostate carcinogenesis by 9-cis-retinoic acid. Cancer Res. 59: 521-524.
  • Rao KV; Johnson WD; Bosland MC; Lubet RA; Steele VE; Kelloff GJ; McCormick DL (1999) Chemoprevention of rat prostate carcinogenesis by early and delayed administration of dehydroepiandrosterone. Cancer Res 59:3084-9.
  • Reddy BS, Kawamori T, Lubet RA, Steele VE, Kelloff GJ, Rao CV. (1999) Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process. Cancer Res 15;59(14):3387-91.
  • Reddy BS, Kawamori T, Lubet R, Steele V, Kelloff G, Rao CV. (1999) Chemopreventive effect of S-methylmethane thiosulfonate and sulindac administered together during the promotion/progression stages of colon carcinogenesis. Carcinogenesis 20(8):1645-8.
  • Rodriguez-Burford, C., Lubet, R.A., Eto, I., Juliana, M.M., Kelloff, G.J., Grubbs, C.J., and Steele, V.E. (1999) Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea (MNU)- induced mammary cancer model. Carcinogenesis 20(1):71-76.
  • Shao J, Sheng H, Aramandla R, Pereira MA, Lubet RA, Hawk E, Grogan L, Kirsch IR, Washington MK, Beauchamp RD, DuBois RN. (1999) Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis 20(2):185-91.
  • Sneige N; Lagios MD; Schwarting R; Colburn W; Atkinson E; Weber D; Sahin A; Kemp B; Hoque A; Risin S; Sabichi A; Boone C; Dhingra K; Kelloff G; Lippman S (1999) Interobserver reproducibility of the Lagios nuclear grading system for ductal carcinoma in situ. Hum Pathol 30:257-62.
  • Steele, V.E., Bagheri, D. Balentine, D.A., Boone, C.W., Mehta, R., Morse, M.A., Sharma, S., Sigman, C.C., Stoner, G.D., Wargovich, M.J., Weisburger, J.H., Zhu, S., and Kelloff, G.J. (1999) Preclinical efficacy studies of green and black tea extracts. Fed. Proc. Exp. Biol. 220:210-212
  • Steele, V.E., Holmes, C.A., Hawk, E.T., Kopelovich, L., Lubet, R.A., Crowell, J.A., Sigman, C.C., and Kelloff, G.J. (1999) Lipoxygenase inhibitors as potential cancer chemopreventives. Cancer Epidemiology, Biomarkers, and Prevention 8:467-483.
  • Stoner GD, Budd GT, Ganapathi R, DeYoung B, Kresty LA, Nitert M, Fryer B, Church JM, Provencher K, Pamukcu R, Piazza G, Hawk E, Kelloff G, Elson P, van Stolk RU. (1999) Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis. Adv Exp Med Biol. 470:45-53.
  • Urban D; Myers R; Manne U; Weiss H; Mohler J; Perkins D; Markiewicz M; Lieberman R; Kelloff G; Marshall M; Grizzle W (1999) Evaluation of biomarker modulation by fenretinide in prostate cancer patients. Eur Urol 35:429-38.
  • Veronesi U, De Palo G, Marubini E, Costa A, Formelli F, Mariani L, Decensi A, Camerini T, Del Turco MR, Di Mauro MG, Muraca MG, Del Vecchio M, Pinto C, D'Aiuto G, Boni C, Campa T, Magni A, Miceli R, Perloff M, Malone WF, Sporn MB. (1999) Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst. Nov 3;91(21):1847-56.
    [PubMed Abstract]
  • White, E.L., Ross, L.J., Steele, V.E., Kelloff, G.J., and D.L. Hill. (1999) Screening of cancer preventive chemicals as aromatase inhibitors in vitro. Anticancer Res. 19:1017-1020.
  • Zheng, Y., Kramer, P.M., Lubet, R.A., Steele, V.E., Kelloff, G.J., and Pereira, M.A. (1999) Effects of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis, and aberrant crypt foci. Carcinogenesis 20(2):255-260.
  • Arif JM; Gairola CG; Glauert HP; Kelloff GJ; Lubet RA; Gupta RC (1998) Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz. Carcinogenesis 19:1515-7.
  • Berton TR; Conti CJ; Mitchell, DL; Aldaz CM; Lubet RL; Fischer SM. (1998) The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis. Molecular Carcinogenesis 23: 175-184.
  • Boone CW, Kelloff, GJ. (1998) Endpoint markers for clinical trials of chemopreventive agents derived from the properties of epithelial precancer (intraepithelial neoplasia) measured by computer-assisted image analysis. Cancer Surv 32:133-47.
  • Boone, C.W., Steele, V.E., Gaylor, D., and Kelloff, G.K. (1998) Use of Druckrey analysis to quantitatively evaluate the chemopreventive efficacy of N-difluoro-methylornithine (DFMO), aprototype proliferation inhibitor. Mutation Res. 402:173-177.
  • Chi WJ; Doong SL; Lin-Shiau SY; Boone CW; Kelloff GJ; Lin JK (1998) Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein. Carcinogenesis 19:2133-8.
  • Conaway, C.C., Chung, F.L., Rivenson, A., Steele, V.E., Kelloff, G.J., Jiao, D(1998) Chemopreventive potential of fumaric acid, N-acetylcysteine, N-(4-hydroxyphenyl) retinamide and beta-carotene for tobacco-nitrosamine-induced lung tumors in A/J mice. Cancer Lett 124(1):85-93.
  • Kelloff, G.J., Sigman, C.C., Boone, C.W., Hawk, E.T., Crowell, J.A., Steele, V.E., Eisenhauer, K., Lieberman, R., Lubet, R.A. (1998) Aromatase inhibitors as potential cancer chemopreventives. Cancer Epidemiol Biomarkers Prev 7(1):65-78.
  • Li, H., Pereira, M.A., Kelloff, G.J., Steele, V.E., Lubet, R.A., Kramer, P.M. (1998) Effect of calcium on azoxymethane-induced aberrant crypt foci and cell proliferation in the colon of rats. Cancer Lett 124(1):39-46.
  • Lieberman R, Crowell JA, Hawk ET, Boone CW, Sigman CC, Kelloff GJ. (1998) Development of new cancer chemoprevention agents: role of pharmacokinetic/pharmacodynamic and intermediate endpoint biomarker monitoring. Clin Chem 44(2):420-7.
  • Lubet, R.A., Moon, R.D., Thomas, C.F., Kelloff, G.J., Steele, V.E., Grubbs, C.J., Wang, Y., You, M., Lei, X.D. Prough, R.A., Gordon, G.B. (1998) Modulation of methylnitrosourea-induced breast cancer in Sprague-Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations. Cancer Res Mar 1;58(5):921-6.
  • Lubet, R.A., Steele, V.E., DeCoster, R., Bowden, C., You, M., Juliana, M.M., Eto, I., Kelloff, G.J., Grubbs, C.J. (1998) Chemopreventive effects of the aromatase inhibitor vorozole (R83842) in the methylnitrosourea-induced mammary cancer model. Carcinogenesis 19(8):1345-1351.
  • McCormick, D.L., Rao, K.V.N., Dooley, L., Steele, V.E., Lubet, R.A., and Kelloff, G.J., and Bosland, M.C. (1998) Influence of N-methyl-N-nitrosourea, testosterone, and N-(4- hydroxyphenyl)-all-trans-retinamide on prostate cancer in Wistar-Unilever rats. Cancer Research 58:3282-3288.
  • Negrusz A, Moore CM, McDonagh NS, Woods EF, Crowell JA, Levine BS. (1998) Determination of phenethylamine, a phenethyl isothiocyanate marker, in dog plasma using solid-phase extraction and gas chromatography-mass spectrometry with chemical ionization. J Chromatogr B Biomed Sci Appl. Oct 23;718(1):193-8.
  • Pezzuto, J.M. and Steele, V.E. (eds.) (1998) Exploring the Power of Phytochemicals: Research Advances on Grape Compounds. Pharmaceutical Biology. Volume 36. Swets and Zeitlinger, Lisse, Netherlands.
  • Prashad, R., Sanford, K.K., Price, F.M., Steele, V.E., Tarone, R.E., Kelloff, G.J., and Boone, C.W. (1998) Protective action of plant polyphenols on radiation-induced chromatid breaks in cultured human cells. AntiCancer Res 18:3263-3266.
  • Ruffin MT 4th, Krishnan K, Rock CL, Normolle D, Vaerten MA, Peters-Golden M, Crowell J, Kelloff G, Boland CR, Brenner DE. (1998) Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose. J Natl Cancer Inst. 1997 Aug 6;89(15):1152-60.
  • Sabourin CL; Wang QS; Ralston SL; Evans J; Coate J; Herzog CR; Jones SL; Weghorst CM; Kelloff GJ; Lubet RA; You M; Stoner GD (1998) Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors. Exp Lung Res 24:499-521.
  • Steele, V.E., Boone, C.W., Lubet, R.A., Crowell, J.A., Holmes, C.A., Sigman, C.C., and Kelloff, G.J. (1998) Preclinical drug development paradigms for chemopreventives. Hematology/Oncology Supplement 12(5):943-961.
  • Steele, V.E., Wyatt, G.P., Kelloff, G.J., and E. Elmore. 1998. Differential growth response to exogenous calcium in normal and carcinogen-exposed primary human keratinocyte cell cultures. Anticancer Res 18(6):4067-4070.
  • Steele, V.E., Wargovich, M.J., McKee, K., Sharma, S., Wilkinson, B.P., Wyatt, G.P., Gao, P., and Kelloff, G.J. 1998. Cancer chemoprevention drug development strategies for resveratrol. Pharmaceutical Biology 36(3): 1-7
  • Thompson, H.J., McGinley, J.N., Wolfe, P., Steele, V.E., Kelloff, G.J., and Singh, M. 1998. Temporal sequence of mammary intraductal proliferations, ductal carcinomas in situ and adenocarcinomas induced by 1-methyl-1-nitrosourea in rats. Carcinogenesis 19(12): 2181-2185.
  • Weisburger, J.H., Zang, E., Pittman, B., Balentine, D.A., Steele, V.E., Boone, C..W., Kelloff, G.J., Reinhardt, J., Aliaga, C., Rivenson, A. (1998) Effect of tea extracts, polyphenols, and epigallocatechin gallate on azoxymethane-induced colon cancer. Proc Soc Exp Biol Med 217(1):104-8.
  • White, E.L., Hill, D.L., Kelloff, G.J., Steele, V.E., Ross, L.J. (1998)Screening of potential cancer preventing chemicals as antioxidants in an in vitro assay Anticancer Res 18(2A):769-73.
  • White, E.L., Hill, D.L., Steele, V.E., Kelloff, G.J., Schmid, S.M., Ross, L.J. (1998)Screening of potential cancer-preventing chemicals for inhibition of induction of ornithine decarboxylase in epithelial cells from rat trachea.Oncol Rep 5(3):717-22.
  • White, E.L., Hill, D.L., Steele, V.E., Kelloff, G.J., Schmid, S.M., Ross, L.J. (1998) Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells. Oncol Rep 5(2):507-12.
  • Arnold, J.T., Wilkinson, B.P., Sharma, S., and Steele, V.E. (1997) Chemoprevention of carcinogen-induced transformation in primary rat tracheal epithelial cells. Methods in Cell Science 19(1): 3-8.
  • Bacus, J.W., Boone, C.W., Kelloff, G.J., Moon, R.C., Stoner, G.D., Bacus, J.V. (1997) Quantitation of preinvasive neoplastic progression in animal models of chemical carcinogenesis. J Cell Biochem Suppl;28-29:21-38.
  • Boone, C.W., Kelloff, G.J., Steele, V.E., Bacus, J.V., Bacus, J.W. (1997) Properties of intraepithelial neoplasia relevant to the development of cancer chemopreventive agents. J Cell Biochem Suppl;28-29:1-20.
  • Boone, C.W., Kelloff, G.J. (1997): Biomarker end-points in cancer chemoprevention trials. IARC Sci Publ;(142):273-80.
  • Boone, C.W., Kelloff, G.J., Steele, V.E., Bacus, J.V., Bacus, J.W. (1997) Properties of intraepithelial neoplasia relevant to cancer chemoprevention and to the development of surrogate end points for clinical trials. Proc Soc Exp Biol Med 216(2):151-65.
  • Boiko, I.V., Hittelman, W.N., Atkinson, E.N., Boone, C.W., Nishioka, K., Malpica, A., Hu, W., White, R.A., Pandey, D.K., Mitchell, M.F. (1997) DNA image cytometric measurement as a surrogate end point biomarker in a phase I trial of alpha-difluoromethylornithine for cervical intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev 6(10):849-55.
  • Crist, K.A., You, M, Kelloff, G.J., Steele, V.E., Lubet, R.A., Wang Y (1997)Effect of early vs. late administration of 4-hydroxyphenylretinamide (4-HPR) on N-methyl-N-nitrosourea (MNU)-induced mammary tumorigenesis. J Cell Biochem Suppl;27:92-9.
  • Crowell, J.A., Kelloff, G.J., Hall, L.B., Goldenthal, E.I., Heath, J.E., Rodman, L.E., Page, J.G. (1997) Chronic toxicity studies of 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione, a potential chemopreventive agent. Fundam Appl Toxicol 35(1):9-21.
  • Duewer DL, Thomas JB, Kline MC, MacCrehan WA, Schaffer R, Sharpless KE, May WE, Crowell JA. (1997) NIST/NCI Micronutrients Measurement Quality Assurance Program: measurement repeatabilities and reproducibilities for fat-soluble vitamin-related compounds in human sera. Anal Chem. Apr 1;69(7):1406-13.
  • Elmore, E., Sun, C., Li, H-R, Wyatt, G.P., Buchmeier, J.A., Steele, V.E, and Redpath, J.L. (1997) The human epidermal cell assay for chemopreventive agents. Methods in Cell Science 19(1): 13-18.
  • Herzog, C.R., You, M., Lubet, R.A. (1997)Genetic alterations in mouse lung tumors: implications for cancer chemoprevention.J Cell Biochem Suppl 28-29:49-63.
  • Hirsch, F.R., Mulshine, J.L., Pastorino, U., Linnoila, R.I., Kelloff, G.J., Gritz, E., Gray, N., Brambilla, E. (1997 ) Prevention and early detection of lung cancer-clinical aspects. Lung Cancer 17(1):163-74.
  • Hu, L., Wang, Y., You, M., Lubet, R.A., Steele, V.E., Kelloff, G.J., Crist, K.A., Lin L (1997) Detection of differentially expressed genes in methylnitrosourea-induced rat mammary adenocarcinomas. J Cell Biochem Suppl;28-29:117-24.
  • Jang, M-S. and Pezzuto, J.M. (1997) Assessment of cyclooxygenase inhibitors using in vitro assay systems. Methods in Cell Science 19(1): 25-31.
  • Kelloff, G.J., Lubet, R.A., Fay, J.R., Steele, V.E., Boone, C.W., Crowell, J.A., and Sigman, C.C. (1997) Farnesyl protein transferase inhibitors as potential cancer chemopreventives. Cancer Epidemiology Biomarkers & Prevention 6: 267-282.
  • Kelloff, G.J., Hawk, E.T., Karp, J.E., Crowell, J.A., Boone, C.W., Steele, V.E., Lubet, R.A and Sigman, C.C. (1997) Progress in Clinical Chemoprevention. Semin. Oncol. 24 (2): 241-252.
  • Kelloff, G.J., Sigman, C.C., Lubet, R.A., Steele, V.E., Hawk, E.T., Nayfield, S.G., Crowell, J.A., Boone, C.W. (1997) Perspectives and progress in development of breast cancer chemopreventive drugs. Prog Clin Biol Res;396:159-83.
  • Lantry, L.E., You, M., Lubet, R.A., Kelloff, G.J., Wang, Y., Crist, K.A., Gao, F., Zhang, Z. (1997)Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung. J Cell Biochem Suppl;27:20-5.
  • Lubet, R.A., Steele, V.E., Eto, I., Juliana, M., Kelloff, G., and Grubbs, C.J. (1997) Chemopreventive efficacy of anethole trithione, N-acetyl-l-cysteine, miconazole, and phenethylisothiocyanate in the DMBA-induced rat mammary cancer model. Int J. Cancer 72:1-7.
  • Matzinger, S.A., You, M., Lubet, R.A., Kelloff, G.K., Stoner, G.D., Crist, K.A., Wang, Y., Chen, B. (1997) Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice. Gene 188(2):261-9.
  • Mehta, R.G., Hawthorne, M.E., and Steele, V.E. (1997) Induction and prevention of carcinogen-induced precancerous lesions in mouse mammary gland organ culture. Methods in Cell Science 19(1): 19-24.
  • Mehta, R.G., Steele, V.E., Pierson, H., Constantinou, A., and Moon, R.C. 1997. Licorice: Absorption, distribution, metabolism and cancer prevention. In: Lachance P.A. (ed.) Nutriceuticals: Designer Foods III Garlic, Soy, and Licorice, Trumbull, CT: Food and Nutrition Press, Inc., pp265-278.
  • Morse, M.A., Stoner, G.D., Harbowy, M.E., Balentine, D.A., Boone, C.W., Kelloff, G.J., Steele, V.E., Kresty, L.A. (1997) Effects of theaflavins on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis. Nutr Cancer;29(1):7-12.
  • Rao, C.V., Reddy, B.S., Steele, V., Kelloff, G., Lubet, R., Simi, B., Wang, C.X. (1997 ) Enhancement of experimental colon cancer by genistein.Cancer Res 57(17):3717-22.
  • Reddy, B.S., Rao, C.V., Kelloff, G.J., Steele, V.E., Lubet, R., Samaha H; Wang CX (1997 ) Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. Cancer Res 57(3):420-5.
  • Ruffin, M.T.4th, Brenner, D.E., Boland, C.R., Kelloff, G., Crowell, J., Peters-Golden, M., Vaerten, M.A., Normolle, D., Rock, C.L., Krishnan, K. (1997 ) Suppression of human colorectal mucosal prostaglandins: determining the lowest effective aspirin dose. J Natl Cancer Inst 89(15):1152-60.
  • Samaha, H.S., Kelloff, G.K., Steele, V.E., Rao, C.V., and Reddy, B.S. (1997) Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Research 57: 1301-1305.
  • Sharma, S., Nemecz, S. K., Zhu, S. and Steele, V.E. (1997) Identification of chemopreventive agents by screening for induction of glutathione-S-transferase as a biomarker. Methods in Cell Science 19(1): 49-52.
  • Sharma, S., Pennington, L.P. and Steele, V.E. (1997) Induction of NADPH-quinone reductase as a screening assay for potential chemopreventive agents. Methods in Cell Science 19(1):63-66.
  • Sharma, S., Stutzman, J.D., Garris, K.R., and Steele, V.E. (1997) An ornithine decarboxylase activity assay to screen for potential chemopreventive agents. Methods in Cell Science 19(1):33-36.
  • Sharma, S., Wilkinson, B.P., and Steele, V.E. (1997) Development of glutathione induction as a screening assay for potential chemopreventive agents. Methods in Cell Science 19(1):53-56.
  • Sharma, S., Wyatt, G.P., Elmore, E., and Steele,V.E. (1997) The A427 anchorage-independence assay as a screening tool to identify potential chemopreventive agents. Methods in Cell Science 19(1): 9-12.
  • Sharma, S., Wyatt, G.P., and Steele, V.E. (1997) A carcinogen -DNA binding assay as a biomarker screen for identifying potential chemopreventive agents. Methods in Cell Science 19(1): 45-48.
  • Steele, V.E. (ed.) (1997) Methods in Cell Science. In Vitro Methods to Screen Chemopreventive Agents. Volume 19. Kluwer Academic Publishers, Dordrecht, Netherlands.
  • Steele, V.E., Boone, C.W., Lubet, R.A., Sigman, C.C., and Kelloff, G.J. (1997) Rationale for the selection and use of in vitro assays to screen for chemopreventive agents. Methods in Cell Science 19(1):1-2.
  • Stoner, G.D., Kelloff, G.J., Morse, M.A. (1997) Perspectives in cancer chemoprevention. Environ Health Perspect 105 Suppl 4:945-54.
  • Wattenberg, L.W., Kelloff, G.J., Steele, V.E., Zimmerman, C.L., Estensen, R.D., Wiedmann, T.S. (1997 ) Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res Dec 15;57(24):5489-92.
  • Zheng, Y., Pereira, M.A., Kelloff, G.J., Steele, V.E., Lubet, R.A., Olson G; Kramer PM (1997) Prevention by retinoids of azoxymethane-induced tumors and aberrant crypt foci and their modulation of cell proliferation in the colon of rats. Carcinogenesis Nov;18(11):2119-25.
  • Burney, K.D., Krishnan, K., Ruffin, M.T., Zhang, D. and Brenner, D.E. (1996) Adherence to single daily dose of aspirin in a chemoprevention trial. An evaluation of self-report and microelectronic monitoring. Arch. Fam. Med. 5: 297-300.
  • Chung, F.-L., Kelloff, G., Steele, V., Pittman, B., Zang, E., Jiao, D., Rigotty, J., Choi, C.-I. and Rivenson, A. (1996) Chemopreventive efficacy of arylalkyl isothiocyanates and N-acetylcysteine for lung tumorigenesis in Fischer rats. Cancer Res. 56: 772-778.
  • Crist, K.A., Kim, K., Goldblatt, P.J., Boone, C.W., Kelloff, G.J., and You, M. (1996) DNA quantitation in cervical intraepithelial neoplasia thick tissue sections by confocal laser scanning microscopy. J. Cell. Biochem. Suppl. 25: 49-56.
  • Dimitrov NV, Meyer-Leece C, McMillan J, Gilliland D, Perloff M, Malone W. (1996) Plasma alpha-tocopherol concentrations after supplementation with water- and fat-soluble vitamin E. Am J Clin Nutr. Sep;64(3):329-35.
    [PubMed Abstract]
  • Gould, M.N., Lubet, R.A., Kelloff, G.J. and Haag, J.D. (1996) Inherited susceptibility and acquired allelic imbalance in rat mammary carcinogenesis. J. Cell. Biochem. Suppl. 25: 37-40.
  • Greenwald, P. and Kelloff, G.J. (1996) The role of chemoprevention in cancer control. Principles of Chemoprevention, IARC Scientific Publication No. 139, Lyon, France: International Agency for Research on Cancer, pp. 13-23.
  • Hawk, E., Kelloff, G., Prindiville, S. (1996) NSAID trials, sporadic adenomas, and conservative inferences. Gastroenterology 110(2):654-5.
  • Hellriegel, E.T., Kong, A.N., Lubet, R.A., Nims, R.W., Dragnev, K.H., Fei, P., Matwyshyn, G.. (1996) Regulation of gene expression of various phase I and phase II drug-metabolizing enzymes by tamoxifen in rat liver. Biochem Pharmacol Nov 22;52(10):1561-8.
  • Jacoby, R.F., Marshall, D.J., Newton, M., Novakovic, K., Tutsch, K., Cole, C.E., Lubet, R.A., Kelloff, G.J., Verma, A., Moser, A.R. and Dove, W.S. (1996) Chemoprevention of spontaneous intestinal adenomas in the ApcMIN model by the nonsteroidal antiinflammatory drug piroxicam. Cancer Res. 56: 710-714.
  • Karp, J.E., Chiarodo, A., Brawley, O. and Kelloff, G.J. (1996) Prostate cancer prevention: Investigational approaches and opportunities. Cancer Res. 56: 5547-5556.
  • Kelloff, G.J. and Boone, C.W. (eds.) (1996) Cancer Chemopreventive Agents: Drug Development Status and Future Prospects III, J. Cell. Biochem. (Suppl. 26), New York, NY: Wiley-Liss.
  • Kelloff, G.J. and Boone, C.W. (eds.) (1996) Prospects for Chemoprevention in Cohorts with Cancer Risk Markers, J. Cell. Biochem. (Suppl. 25), New York, NY: Wiley-Liss.
  • Kelloff, G.J., Boone, C.W., Crowell, J.A., Nayfield, S.G., Hawk, E., Malone, W.F., Steele, V.E., Lubet, R.A. and Sigman, C.C. (1996) Risk biomarkers and current strategies for cancer chemoprevention. J. Cell. Biochem. Suppl. 25: 1-14.
  • Kelloff, G.J., Boone, C.W., Crowell, J.A., Steele, V.E., Lubet, R.A., Doody, L.A., Malone, W.F., Hawk, E.T. and Sigman, C.C. (1996) New agents for cancer chemoprevention. J. Cell. Biochem. Suppl. 26: 1-28.
  • Kelloff, G.J., Boone, C.W., Sigman, C.C. and Greenwald, P. (1996) Chemoprevention of colorectal cancer. In: Young, G.P., Levin, B. and Rozen, P. (eds.) Prevention and Early Detection of Colorectal Cancer: Principles and Practice, London, England: W.B. Saunders, pp. 115-139.
  • Kelloff, G.J., Boone, C.W., Steele, V.E., Crowell, J.A., Lubet, R.A., Greenwald, P., Hawk, E.T., Fay, J.R. and Sigman, C.C. (1996) Mechanistic considerations in the evaluation of chemopreventive data. Principles of Chemoprevention, IARC Scientific Publication No. 139, Lyon, France: International Agency for Research on Cancer, pp. 203-221.
  • Kelloff, G.J., Fay, J.R., Steele, V.E., Lubet, R.A., Boone, C.W., Crowell, J.A. and Sigman, C.C. (1996) Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives. Cancer Epidemiol. Biomark. Prev. 5: 657-666.
  • Kelloff, G.J., Hawk, E.T., Crowell, J.A., Boone, C.W., Nayfield, S.G., Perloff, M., Steele, V.E., Lubet, R.A and Sigman, C.C. (1996) Strategies for identification and clinical evaluation of promising chemopreventive agents. Oncology 10: 1471-1484.
  • Kelloff, G.J., Sigman, C.C., Lubet, R.A., Steele, V.E., Boone, C.W., Crowell, J.A., Hawk, E.T. (1996) Perspectives on chemoprevention agent selection and short-term clinical prevention trials. Eur J Cancer Prev 5 Suppl 2:79-85.
  • Kensler, T.W. and Groopman, J.D. (1996) Carcinogen-DNA and protein adducts: Biomarkers for cohort selection and modifiable endpoints in chemoprevention trials. J. Cell. Biochem. Suppl. 25: 85-91.
  • Korytynski, E.A., Kelloff, G.J., Suk, W.A., Sharma, A. and Elmore, E. (1996) The development of an anchorage-independence assay using human lung tumor cells to screen potential chemopreventive agents. Anticancer Res. 16: 1091-1094.
  • Liu, J., Wang, Y., Gu, P., Patrick, J., Crist, K.A., Sabourin, C., Stoner, G.D., Mitchell, M.F., Fanning, J.D., Kim, K., Goldblatt, P.J., Kelloff, G.J., Boone, C.W. and You, M. (1996) Detection of genomic alterations in human cervical cancer by two-dimensional gel electrophoresis. J. Cell. Biochem. Suppl. 25: 41-48.
  • McCormick, D.L., Johnson, W.D., Rao, K.V.N., Bowman-Gram, T., Steele, V.E., Lubet, R.A. and Kelloff, G.J. (1996) Chemoprevention of lymphoma development in PIM transgenic mice by N-(4-hydroxyphenyl)retinamide and -difluoromethylornithine. Carcinogenesis 17: 2513-2518.
  • McCormick, D.L., Rao, K.V.N., Johnson, W.D., Bowman-Gram, T.A., Steele, V.E., Lubet, R.A. and Kelloff, G.J. (1996) Exceptional chemopreventive activity of low dose dehydroepiandrosterone in the rat mammary gland. Cancer Res. 56: 1724-1726.
  • Mitchell, M.F., Morrow, P.C., Boone, C.W. and Kelloff, G.J. (eds.) (1996) Cancer Chemoprevention: Cervix, Endometrium and Ovary. J. Cell. Biochem. (Suppl. 23), New York, NY: Wiley-Liss.
  • Pereira, M.A., Barnes, L.H., Steele, V.E., Kelloff, G.J. and Lubet, R.A. (1996) Piroxicam-induced regression of azoxymethane-induced aberrant crypt foci and prevention of colon cancer in rats. Carcinogenesis 17: 373-376.
  • Pereira, M.A., Grubbs, C.J., Barnes, L.H., Li, H., Olson, G.R., Eto, I., Juliana, M., Whitaker, L.M., Kelloff, G.J., Steele, V.E. and Lubet, R.A. (1996) Effects of the phytochemicals, curcumin and quercetin, upon azoxymethane-induced colon cancer and 7,12-dimethylbenz(a)anthracene-induced mammary cancer in rats. Carcinogenesis 17: 1305-1312.
  • Rao, C.V., Rivenson, A., Zang, E. Steele, V., Kelloff, G. and Reddy, B.S. (1996) Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced lymphoma formation by oltipraz. Cancer Res. 56: 3395-3398.
  • Rao, K.V.N., McCormick, D.L., Detrisac, C.J., Steele, V.E., Hawk, E.T. and Kelloff, G.J. (1996) Differential activity of aspirin, ketoprofen, and sulindac as cancer chemopreventive agents in the mouse urinary bladder. Carcinogenesis 17: 1435-1438.
  • Risio M., Lipkin, M., Newmark, H., Yang, K., Steele, V.E., Boone, C.W. and Kelloff, G.J. (1996) Apoptosis, cell replication and Western-style diet-induced tumorigenesis in mouse colon. Cancer Res. 56: 4910-4916.
  • Schottenfeld, D., Mitchell, M.F. and Hong, W.K. (1996) Screening and chemoprevention of gynecologic tumors. Obstet. Gynecol. Clin. North Am. 23: 285-294.
  • Steele, V.E., Sharma, S., Mehta, R., Elmore, E., Redpath, L., Rudd, C., Carter, C., Bagheri, D., Sigman, C.C., and Kelloff, G.J. (1996) Use of in vitro assays to predict the efficacy of chemopreventive agents in whole animals. J. Cell. Biochem. Suppl. 26: 29-53.
  • Wargovich, M.J., Chen, C-D., Jimenez, A., Steele, V.E., Velasco, M., Stephens, L.C., Price, R., Gray, K. and Kelloff, G.J. (1996) Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol. Biomarkers & Prev. 5: 355-360.
  • Yang, K., Fan, K., Newmark, H., Leung,, D., Lipkin, M., Steele, V.E. and Kelloff, G.J. (1996) Cytokeratin, lectin, and acidic mucin modulation in differentiating colonic epithelial cells of mice after feeding Western-style diets. Cancer Res.56: 4644-4648.
  • Anderson, L., Steele, V.K., Kelloff, G.J. and Sharma, S. (1995) Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver. J. Cell. Biochem. 22: 108-116.
  • Arnold, J.T., Wilkinson, B.P., Sharma, S. and Steele, V.E. (1995) Evaluation of chemopreventive agents in different mechanistic classes using a rat tracheal epithelial cell culture transformation assay. Cancer Res. 55: 537-543.
  • Boone, C.W. and Kelloff, G.J. (1995) Biomarkers of premalignant breast disease and their use as surrogate endpoints in clinical trials of chemopreventive agents. The Breast J. 1: 228-235.
  • Cervantes, M., Zhou, H., Sahin, A., Dhingra, K., Valero, V., Ordonez, N., El-Naggar, A., Hess, K., Glassman, A. and Sen, S. (1995) p53 alterations show significant correlation with gene amplification and high S-phase index in breast cancer. Int. J. Oncol. 6: 955-962.
  • Dhingra, K. (1995) A Phase II chemoprevention trial design to identify surrogate endpoint biomarkers in breast cancer. J. Cell. Biochem. 23: 19-24.
  • Dragnev, K.H., Lubet, R.A., Nims, R.W. (1995) The chemopreventive agent diallyl sulfide. A structurally atypical phenobarbital-type inducer. Biochem Pharmacol 50(12):2099-104.
  • Greenwald P., Clifford, C., Pilch, S., Heimendinger, J. and Kelloff, G. (1995) New directions in dietary studies in cancer: The National Cancer Institute. In: Longnecker, J.B. (ed.) Nutrition and Biotechnology in Heart Disease and Cancer, New York, New York: Plenum Press, 229-239.
  • Greenwald, P., Kelloff, G.J., Boone, C.W. and McDonald, S.S. (1995) Genetic and cellular changes in colorectal cancer: Proposed targets of chemopreventive agents. Cancer Epidemiol. Biomark. Prev. 5: 691-702.
  • Greenwald, P., Kelloff, G., Burch-Whitman, C. and Kramer, B.S. (1995) Chemoprevention. CA A Cancer Journal for Clinicians 45: 31-49.
  • Grubbs, C.J., Steele, V.E., Casebolt, T., Juliana, M.M., Eto, I., Whitaker, L.M., Dragnev, K.H., Kelloff, G.J. and Lubet, R.L. (1995) Chemoprevention of chemically-induced mammary carcinogenesis by indole-3-carbinol. Anticancer Res. 15: 709-716.
  • Gupta, E., Olopade, O.I., Ratain, M.J., Mick, R., Baker, T.M., Berezin, F.K., Benson, A.B., III and Dolan, M.E. (1995) Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent. Clin. Cancer Res. 1: 1133-1138.
  • Kelloff, G.J. and Boone, C.W. (eds.) (1995) Cancer Chemopreventive Agents: Drug Development Status and Future Prospects II, J. Cell. Biochem. (Suppl. 22), New York, NY: Wiley-Liss.
  • Kelloff, G.J., Boone, C.W., Crowell, J.A., Nayfield, S.G., Hawk, E., Steele, V.E., Lubet, R.A. and Sigman, C.C. (1995) Development of breast cancer chemopreventive drugs. The Breast J. 1: 271-283.
  • Kelloff, G.J., Boone, C.W., Crowell, J.A., Nayfield, S.G., Hawk, E., Steele, V.E., Lubet, R.A. and Sigman, C.C. (1995) Strategies for Phase II cancer chemoprevention trials: Cervix, endometrium, and ovary. J. Cell. Biochem. Suppl. 23: 1-9.
  • Kelloff, G.J., Boone, C.W., Steele, V.E., Fay, J.R. and Sigman, C.C. (1995) Inhibition of chemical carcinogenesis. In: Arcos, J., Argus, M. and Woo, Y. (eds.) Chemical Induction of Cancer: Modulation and Combination Effects, Boston, MA: Birkhäuser Boston, Inc., pp. 73-122.
  • Kelloff, G.J., Johnson, J.R., Crowell, J.A., Boone, C.W., DeGeorge, J.J., Steele, V.E., Mehta, M.U., Temeck, J.W., Schmidt, W.J., Burke, G., Greenwald, P. and Temple, R.J. (1995) Approaches to the development and marketing approval of drugs that prevent cancer. Cancer Epidemiol. Biomark. Prev. 4: 1-10.
  • Kensler, T.W. and Helzlsouer, K.J. (1995) Oltipraz: clinical opportunities for cancer chemoprevention. J. Cell. Biochem. Suppl. 22: 101-107.
  • Lubet, R.A., McCormick, D.M., Gordon, G.M., Grubbs, C., Lei, X.-D., Prough, R.A., Steele, V.E., Kelloff, G.J., Thomas, C.F. and Moon, R.C. (1995) Effects of dehydroepiandrosterone on MNU-induced breast cancer in Sprague-Dawley rats. Ann. N.Y. Acad. Sci. 774: 340-341.
  • Matzinger, S.A., Crist, K.A., Stoner, G.D., Anderson, M.W., Pereira, M.A., Steele, V.E., Kelloff, G.J., Lubet, R.A. and You, M. (1995) K-ras mutations in lung tumors from A/J and A/JxTSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate. Carcinogenesis 16: 2487-2492.
  • Mitchell, M.F., Hittelman, W.N., Lotan, R., Nishioka, K., Tortolero-Luna, G., Richards-Kortum, R. and Hong, W.K. (1995) Chemoprevention trials in the cervix: Design, feasibility, and recruitment. J. Cell. Biochem. 23: 104-112.
  • Mitchell, M.F., Hittelman, W.K., Lotan, R., Nishioka, K., Tortolero-Luna, G., Richards-Kortum, R., Wharton, J.T. and Hong, W.K. (1995) Chemoprevention trials and surrogate end point biomarkers in the cervix. Cancer 76: 1956-1977.
  • Nishioka, K., Melgarejo, A.B., Lyon, R.R. and Mitchell, M.F. (1995) Polyamines as biomarkers of cervical intraepithelial neoplasia. J. Cell. Biochem. 23: 87-95.
  • Pendyala, L. and Creaven, P.J. (1995) Pharmacokinetic and pharmacodynamic studies of N-acetylcysteine, a potential chemopreventive agent, during a Phase I trial. Cancer Epidemiol. Biomark. Prev. 4: 245-251.
  • Primiano, T., Egner, P.A., Sutter, T.R., Kelloff, G.J., Roebuck, B.D. and Kensler, T.W. (1995) Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Cancer Res. 55: 4319-4324.
  • Rao, C.V., Rivenson, A., Kelloff, G.J. and Reddy, B.S. (1995) Chemoprevention of azoxymethane-induced colon cancer by ascorbylpalmitate, carbenoxolone, dimethylfumarate and p-methoxyphenol in male F344 rats. Anticancer Res. 15: 1199-1204.
  • Rao, C.V., Rivenson, A., Simi, B. and Reddy, B.S. (1995) Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 55: 259-266.
  • Rao, C.V., Rivenson, A., Simi, B., Zang, E., Hamid, R., Kelloff, G.J., Steele, V. and Reddy, B.S. (1995) Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate. Cancer Res. 55: 4311-4318.
  • Rao, C.V., Rivenson, A., Simi, B., Zang, E., Kelloff, G., Steele, V. and Reddy, B.S. (1995) Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent. Cancer Res. 55: 1464-1472.
  • Richter, F., Newmark, H.L., Richter, A., Leung, D. and Lipkin, M. (1995) Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium. Carcinogenesis 16: 2685-2689.
  • Schatzkin, A. and Kelloff, G. (1995) Chemo- and dietary prevention of colorectal cancer. Eur. J. Cancer 31A: 1198-1204.
  • Steele, V.E., Pereira, M.A., Sigman, C.C. and Kelloff, G.J. (1995) Cancer chemoprevention agent development strategies for genistein. J. Nutr. 125: 713S-716S.
  • Wargovich, M.J., Chen, C.D., Harris, C., Yang, E. and Velasco, M. (1995) Inhibition of aberrant crypt growth by non-steroidal anti-inflammatory agents and differentiation agents in the rat colon. Int. J. Cancer 60: 515-519.
  • Boone, C. W. and Kelloff, G.J. (1994) Development of surrogate endpoint biomarkers for clinical trials of cancer chemopreventive agents: Relationships to fundamental properties of preinvasive (intraepithelial) neoplasia. J. Cell. Biochem. Suppl. 19: 10-22.
  • Boone, C.W. and Kelloff, G.J. (eds.) (1994) Quantitative Pathology in Chemoprevention Trials: Standardization and Quality Control of Surrogate Endpoint Biomarker Assays for Colon, Breast and Prostate, J. Cell. Biochem. (Suppl. 19), New York, NY: Wiley-Liss.
  • Crowell, J.A., Goldenthal, E.I., Kelloff, G.J., Malone, W.F. and Boone, C.W. (1994) Chronic toxicity studies of the potential cancer preventive 2-(difluoromethyl)-dl-ornithine. Fundam. Appl. Toxicol. 22: 341-354.
  • Kelloff, G.J. and Boone, C.W. (eds.) (1994) Cancer Chemopreventive Agents: Drug Development Status and Future Prospects I, J. Cell. Biochem. (Suppl. 20), New York, NY: Wiley-Liss.
  • Kelloff, G.J., Boone, C.W., Crowell, J.A., Steele, V.E., Lubet, R. and Doody, L.A. (1994) Surrogate endpoint biomarkers for Phase II cancer chemoprevention trials. J. Cell. Biochem. Suppl. 19: 1-9.
  • Kelloff, G.J., Boone, C.W., Crowell, J.A., Steele, V.E., Lubet, R. and Sigman, C.C. (1994) Chemopreventive drug development: Perspectives and progress. Cancer Epidemiol. Biomark. Prev. 3: 85-98.
  • Kelloff, G.J., Boone, C.W., Steele, V.E., Crowell, J.A., Lubet, R. and Sigman, C.C. (1994) Progress in cancer chemoprevention: Perspectives on agent selection and short-term clinical intervention trials. Cancer Res. 54: 2015s-2024s.
  • Kelloff, G.J., Boone, C.W., Steele, V.E., Fay, J.R., Lubet, R.A., Crowell, J.A. and Sigman, C.C. (1994) Mechanistic considerations in chemopreventive drug development. J. Cell. Biochem. Suppl. 20: 1-24.
  • Kelloff, G.J., Johnson, J.J., Crowell, J.A., Boone, C.W., DeGeorge, J.J., Steele, V.E., Mehta, M.U., Temeck, J.W., Schmidt, W.J., Burke, G., Greenwald, P. and Temple, R.J. (1994) Guidance for development of chemopreventive agents. J. Cell. Biochem. Suppl. 20: 25-31.
  • Lipkin, M. (1994) Summary of recommendations for colonic biomarker studies of candidate chemopreventive compounds in Phase II clinical trials. J. Cell. Biochem. 19: 94-98.
  • Lubet, R.A., Steele, V.E., Casebolt, T.L., Eto, I., Kelloff, G.J. and Grubbs, C.J. (1994) Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats. Carcinogenesis 15: 2775-2780.
  • Mitchell, M.F., Hittelman, W.N., Hong, W.K., Lotan, R. and Schottenfeld, D. (1994) The natural history of cervical intraepithelial neoplasia: An argument for intermediate endpoint biomarkers. Cancer Epidemiol. Biomark. Prev. 3: 619-626.
  • Moon, R.C., Kelloff, G.J., Detrisac, C.J., Steele, V.E., Thomas, C.F. and Sigman, C.C. (1994) Chemoprevention of OH-BBN-induced bladder cancer in mice by oltipraz, alone and in combination with 4-HPR and DFMO. Anticancer Res. 14: 5-11.
  • Moon, R.C., Rao, K.V.N., Detrisac, C.J., Kelloff, G.J., Steele, V.E. and Doody, L.A. (1994) Chemoprevention of respiratory tract neoplasia in the hamster by oltipraz, alone and in combination. Int. J. Oncol. 4: 661-667.
  • Moon, R.C., Steele, V.E., Kelloff, G.J., Thomas, C.F., Detrisac, C.J., Mehta, R.G. and Lubet, R.A. (1994) Chemoprevention of MNU-induced mammary tumorigenesis by hormone response modifiers: Toremifene, RU 16117, tamoxifen, aminoglutethimide and progesterone. Anticancer Res. 14: 889-893.
  • Pereira, M.A., Barnes, L.H., Rassman, V.L., Kelloff, G.J. and Steele, V.E. (1994) Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents. Carcinogenesis 15: 1049-1054.
  • Shamon, L.A., Chen, C., Mehta, R.G., Steele, V., Moon, R.C. and Pezzuto, J.M. (1994) A correlative approach for the identification of antimutagens that demonstrate chemopreventive activity. Anticancer Res. 14: 1775-1778.
  • Sharma, S., Stutzman, J.D., Kelloff, G.J. and Steele, V.E. (1994) Screening of potential chemopreventive agents using biochemical markers of carcinogenesis. Cancer Res. 54: 5848-5855.
  • Singh, J., Kulkarni, N., Kelloff, G. and Reddy, B.S. (1994) Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis. Carcinogenesis 15: 1317-1323.
  • Steele, V.E., Moon, R.C., Lubet, R.A., Grubbs, C.J., Reddy, B.S., Wargovich, M., McCormick, D.L., Pereira, M.A., Crowell, J.A., Bagheri, D., Sigman, C.C., Boone, C.W. and Kelloff, G.J. (1994) Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: Methods and results from the NCI chemoprevention testing program. J. Cell. Biochem. Suppl. 20: 32-54.
  • Waterhouse, D.M. and Brenner, D. (1994) Aspirin, NSAIDs, and risk reduction of colorectal cancer. The problem is translation. Arch. Intern. Med. 154: 366-368.
  • Boone, C.W. and Kelloff, G.J. (eds.) (1993) Chemoprevention of Breast Cancer: Surrogate Endpoints and Agents in Short-Term Clinical Trials, J. Cell. Biochem. (Suppl. 17G), New York, NY: Wiley-Liss.
  • Boone, C.W. and Kelloff, G.J. (1993) Intraepithelial neoplasia, surrogate endpoint biomarkers, and cancer prevention. J. Cell. Biochem. 17 (Suppl. F): 37-48.
  • Boone, C.W. and Kelloff, G.J. (1993) Intraepithelial and postinvasive neoplasia as a stochastic continuum of clonal evolution, and its relationship to mechanisms of chemopreventive drug action. J. Cell. Biochem. 17 (Suppl. G): 14-25.
  • Boone, C.W., Kelloff, G.J. and Steele, V.E. (1993) Histopathology of human intraepithelial neoplasia with implications for chemoprevention strategy. Basic Life Sci. 61: 291-300.
  • Creaven, P.J., Pendyala, L. and Petrelli, N.J. (1993) Evaluation of -difluoromethylornithine as a potential chemopreventive agent: Tolerance to daily oral administration in humans. Cancer Epidemiol. Biomark. Prev. 2: 243-247.
  • Dhingra, K., Vogel, V., Sneige, N., Sahin, A., Aldaz, M., Hortobagyi, G.N. and Hittelman, W. (1993) Strategies for the application of biomarkers for risk assessment and efficacy in breast cancer chemoprevention trials. J. Cell. Biochem. 17G: 37-43.
  • Freedman, L.S., Midthune, D.N., Brown, C.C., Steele, V. and Kelloff, G.J. (1993) Statistical analysis of animal cancer chemoprevention experiments. Biometrics 49: 259-268.
  • Greenwald, P. and Kelloff, G.J. (1993) The chemoprevention of cancer. In: General Motors Research Foundation, Accomplishments in Cancer Research 1992, Philadelphia, PA: J.B. Lippincott Co., pp. 242-265.
  • Greenwald, P., Kelloff, G., Kalagher, S. and McDonald, S. (1993) Research studies on chemoprevention of esophageal cancer at the United States National Cancer Institute. Endoscopy 25: 617-626.
  • Grubbs, C.J., Juliana, M.M., Eto, I., Casebolt, T., Whitaker, L.M., Canfield, G.J., Manczak, M., Steele, V.E. and Kelloff, G.J. (1993) Chemoprevention by indomethacin of N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder tumors. Anticancer Res. 13: 33-36.
  • Kelloff, G.J., Boone, C.W., Malone, W.F. and Steele, V. (1993) Recent results in preclinical and clinical drug development of chemopreventive agents at the National Cancer Institute. Basic Life Sci. 61: 373-386.
  • Kelloff, G.J., Boone, C.W., Steele, V.E., Crowell, J.A., Lubet, R., Doody, L.A. and Greenwald, P. (1993) Development of breast cancer chemopreventive drugs. J. Cell. Biochem. 17 (Suppl. G): 2-13.
  • Kelloff, G.J., Boone, C.W., Steele, V.E., Perloff, M., Crowell, J. and Doody, L.A. (1993) Development of chemopreventive agents for lung and upper aerodigestive tract cancers. J. Cell. Biochem. 17 (Suppl. F): 2-17.
  • Love, R.R, Carbone, P.P, Verma, A.K., Gilmore, D., Carey, P., Tutsch, K.D., Pomplun, M. and Wilding, G. (1993) Randomized Phase I chemoprevention dose-seeking study of -difluoromethylornithine. J. Natl. Cancer Inst. 85: 732-737.
  • Moon, R.C., Kelloff, G.J., Detrisac, C.J., Steele, V.E., Thomas, C.F. and Sigman, C.C. (1993) Chemoprevention of OH-BBN-induced bladder cancer in mice by piroxicam. Carcinogenesis 14: 1487-1489.
  • Pendyala, L., Creaven, P.J. and Porter, C.W. (1993) Urinary and erythrocyte polyamines during the evaluation of oral -difluoromethylornithine in a phase I chemoprevention clinical trial. Cancer Epidemiol. Biomark. Prev. 2: 235-241.
  • Rao, C.V., Rivenson, A., Katiwalla, M., Kelloff, G.J. and Reddy, B.S. (1993) Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats. Cancer Res. 53: 2502-2506.
  • Reddy, B.S., Rao, C.V., Rivenson, A. and Kelloff, G. (1993) Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats. Carcinogenesis 14: 1493-1497.
  • Reddy, B.S., Rao, C.V., Rivenson, A. and Kelloff, G. (1993) Chemoprevention of colon carcinogenesis by organosulfur compounds. Cancer Res. 53: 3493-3498.
  • Ruffin, M.T., IV, August, D.A., Kelloff, G.J., Boone, C.W., Weber, B.L. and Brenner, D.E. (1993) Selection criteria for breast cancer chemoprevention. J. Cell. Biochem. 17 (Suppl. G): 234-241.
  • Schantz, S.P., Hong, W.K., Boone, C.W. and Kelloff, G.J. (eds.) (1993) Chemoprevention of Premalignant Lesions of the Upper Aerodigestive Tract, J. Cell. Biochem. (Suppl. 17F), New York, NY: Wiley-Liss.
  • Schantz, S.P., Hong, W.K., Boone, C.W. and Kelloff, G.J. (1993) Strategy for design of clinical trials of chemopreventive agents. J. Cell. Biochem. 17 (Suppl. F): 299-300.
  • Singh, J., Kelloff, G. and Reddy, B.S. (1993) Intermediate biomarkers of colon cancer: Modulation of expression of ras oncogene by chemopreventive agents during azoxymethane induced colon carcinogenesis. Carcinogenesis 14: 699-704.
  • Steele, V.E., Boone, C.W. and Kelloff, G.J. (1993) Strategies for development of chemoprevention agents. Comm. Toxicol. 4: 427-436.
  • Boone, C.W., Kelloff, G.J. and Steele, V.E. (1992) Natural history of intraepithelial neoplasia in humans with implications for cancer chemoprevention strategy. Cancer Res. 52: 1651-1659.
  • Boone, C.W., Kelloff, G.J. and Steele, V.E. (1992) The natural history of intraepithelial neoplasia: Relevance to the search for biomarkers. J. Cell. Biochem. 16 (Suppl. G): 23-26.
  • Boone, C.W., Kelloff, G.J. and Steele, V.E. (1992) Histopathology of human intraepithelial neoplasia with implications for chemoprevention strategy. In: Wattenberg, L., Lipkin, M., Boone, C.W. and Kelloff, G.J. (eds.) Cancer Chemoprevention, Boca Raton, FL: CRC Press, pp. 57-67.
  • Boone, C.W., Steele, V.E. and Kelloff, G.J. (1992) Screening for chemopreventive (anticarcinogenic) compounds in rodents. Mutat. Res. 267: 251-255.
  • Bostwick, D.G., Scardino, P.T., Kelloff, G.J. and Boone, C.W. (eds.) (1992) Chemoprevention of Premalignant and Early Malignant Lesions of the Prostate, J. Cell. Biochem. (Suppl. 16H), New York, NY: Wiley-Liss.
  • Crawford, E.D., Fair, W.R., Kelloff, G.J., Lieber, M.M., Miller, G.J., Scardino, P.T. and DeAntoni, E.P. (1992) Chemoprevention of prostate cancer: Guidelines for possible intervention strategies. J. Cell. Biochem. 16 (Suppl. H): 140-145.
  • Hemstreet, G.P., III, Rao, J.Y., Hurst, R.E., Bonner, R.B., Jones, P.L., Vaidya, A.M., Fradet, Y., Moon, R.C. and Kelloff, G.J. (1992) Intermediate endpoint biomarkers for chemoprevention. J. Cell. Biochem. 16 (Suppl. I): 93-110.
  • Kelloff, G.J., Boone, C.W., Malone, W.F., Steele, V.E. and Doody, L.A. (1992) Introductory remarks: Development of chemopreventive agents for prostate cancer. J. Cell. Biochem. 16 (Suppl. H): 1-8.
  • Kelloff, G.J., Boone, C.W., Malone, W.F. and Steele, V. (1992) Recent results in preclinical and clinical drug development of chemopreventive agents at the National Cancer Institute. In: Wattenberg, L., Lipkin, M., Boone, C.W. and Kelloff, G.J. (eds.) Cancer Chemoprevention, Boca Raton, FL: CRC Press, pp. 41-56.
  • Kelloff, G.J., Boone, C.W., Malone, W.F. and Steele, V.E. (1992) Chemoprevention clinical trials. Mutat. Res. 267: 291-295
  • Kelloff, G.J., Boone, C.W., Malone, W.F., Steele, V.E. and Doody, L.A. (1992) Development of chemopreventive agents for bladder cancer. J. Cell. Biochem. 16 (Suppl. I): 1-12.
  • Kelloff, G.J., Malone, W.F., Boone, C.W., Steele, V.E. and Doody, L.A. (1992) Intermediate biomarkers of precancer and their applications in chemoprevention. J. Cell. Biochem. 16 (Suppl. G): 15-22.
  • Kulkarni, N., Zang, E., Kelloff, G. and Reddy, B.S. (1992) Effect of the chemopreventive agents piroxicam and d,l- -difluoromethylornithine on intermediate biomarkers of colon carcinogenesis. Carcinogenesis 13: 995-1000.
  • Lipkin, M., Levin, B., Kim, Y.S. and Kelloff, G.J. (eds.) (1992) Intermediate Biomarkers of Precancer and Their Application in Chemoprevention, J. Cell. Biochem. (Suppl. 16G), New York, NY: Wiley-Liss.
  • Malone, W.F., Boone, C.W. and Kelloff, G.J. (1992) Drug development status of four leading chemopreventive agents at the National Cancer Institute. In: Wattenberg, L., Lipkin, M., Boone, C.W. and Kelloff, G.J. (eds.) Cancer Chemoprevention, Boca Raton, FL: CRC Press, pp. 597-606.
  • Messing, E.M. and Reznikoff, C.A. (1992) Epidermal growth factor and its receptor: Marker of and targets for chemoprevention of bladder cancer. J. Cell. Biochem. 16I: 56-62.
  • Messing, E.M., Sheinfeld, J., Boone, C.W. and Kelloff, G.J. (eds.) (1992) Chemoprevention of Premalignant and Early Malignant Lesions of the Bladder, J. Cell. Biochem. (Suppl. 16I), New York, NY: Wiley-Liss.
  • Moon, R.C., Detrisac, C.J., Thomas, C.F. and Kelloff, G.J. (1992) Chemoprevention of experimental bladder cancer. J. Cell. Biochem. 16I: 134-138.
  • Moon, R.C., Kelloff, G.J., Detrisac, C.J., Steele, V.E., Thomas, C.F. and Sigman, C.C. (1992) Chemoprevention of MNU-induced mammary tumors in the mature rat by 4-HPR and tamoxifen. Anticancer Res. 12: 1147-1154.
  • Moon, R.C., Mehta, R.G. and Detrisac, C.J. (1992) Retinoids as chemopreventive agents for breast cancer. Cancer Detect. Prev. 16: 73-79.
  • Moon, R.C., Rao, K.V.N, Detrisac, C.J. and Kelloff, G.J. (1992) Hamster lung cancer model of carcinogenesis and chemoprevention. Adv. Exp. Med. Biol. 320: 55-61.
  • Moon, R.C., Rao, K.V.N., Detrisac, C.J. and Kelloff, G.J. (1992) Retinoid chemoprevention of lung cancer. In: Wattenberg, L., Lipkin, M., Boone, C.W. and Kelloff, G.J. (eds.) Cancer Chemoprevention, Boca Raton, FL: CRC Press, pp. 83-93.
  • Moon, R.C., Rao, K.V.N., Detrisac, C.J. and Kelloff, G.J. (1992) Animal models for chemoprevention of respiratory cancer. J. Natl. Cancer Inst. Monogr. 13: 45-49.
  • Reddy, B.S., Tokumo, K., Kulkarni, N., Aligia, C. and Kelloff, G. (1992) Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds. Carcinogenesis 13: 1019-1023.
  • Sheinfeld, J., Herr, H.W., Boone, C.W., Bostwick, D.G., Clark, L.C., Decensi, A.U., de Vere White, R.W., Farrow, G.M., Fradet, Y., Grossman, H.B., Hemstreet, G.P., III, Kelloff, G.J., Koss, L.P., Logothetis, C.J., Loprinzi, C.L., Melamed, M.R., Prout, G., Jr., Reuter, V., Soloway, M.S., von Eschenbach, A.C. and Whitmore, W.F., Jr. (1992) Intervention strategies for chemoprevention of bladder cancer. J. Cell. Biochem. 16I: 173-174.
  • Singh, J., Kelloff, G. and Reddy, B.S. (1992) Effect of chemopreventive agents on intermediate biomarkers during different stages of azoxymethane-induced colon carcinogenesis. Cancer Epidemiol. Biomark. Prev. 1: 405-411.
  • Steele, V.E., Boone, C.W., Stoner, G.D. and Kelloff, G.J. (eds.) (1992) Cellular and Molecular Targets for Chemoprevention, Boca Raton, FL: CRC Press.
  • Wargovich, M.J., Harris, C., Chen, C.-D., Palmer, C., Steele, V.E. and Kelloff, G.J. (1992) Growth kinetics and chemoprevention of aberrant crypts in the rat colon. J Cell. Biochem. 16 (Suppl. G): 51-54.
  • Wattenberg, L., Lipkin, M., Boone, C.W. and Kelloff, G.J. (eds.) (1992) Cancer Chemoprevention, Boca Raton, FL: CRC Press.
  • Alexandrov, V.A., Bespalov, V.G., Boone, C.W., Kelloff, G.J. and Malone, W.F. (1991) Study of postnatal effects of chemopreventive agents on offspring of ethylnitrosourea-induced transplacental carcinogenesis in rats. I. Influence of retinol acetate, -tocopherol acetate, thiamine chloride, sodium selenite, and -difluoromethylornithine. Cancer Lett. 60: 177-184.
  • Boone, C.W., Kelloff, G.J. and Steele, V. (1991) Histopathology of the premalignant process. Cancer Bull. 43: 481-484.
  • Hurst, R.E., Rhodes, S.W., Petrone, R., Bass, R.A., Hemstreet, G.P., Detrisac, C.J., Thomas, C.F., Moon, R.C. and Kelloff, G.J. (1991) Quantitative biochemical markers of DNA hyperploidy as end-point indicators in chemical risk assessment and chemoprevention studies. J. Biol. Mon. 1: 5-18.
  • Lipkin, M., Newmark, H.L. and Kelloff, G.J. (eds.) (1991) Calcium, Vitamin D, and Prevention of Colon Cancer, Boca Raton, FL: CRC Press.
  • Lipkin, M., Newmark, H., Boone, C.W. and Kelloff, G.J. (1991) Calcium, vitamin D, and colon cancer. Cancer Res. 51: 3069-3700.
  • Malone, W.F., Kelloff, G.J. and Boone, C.W. (1991) Ongoing preclinical and initial clinical studies in chemoprevention. In: Pastorino, U. and Hong, W.K. (eds.) Chemoimmuno Prevention of Cancer, Stuttgart, Germany: Thieme, pp. 111-123.
  • Mehta, R.G. and Moon, R.C. (1991) Characterization of effective chemopreventive agents in mammary gland in vitro using an initiation-promotion protocol. Anticancer Res. 11: 593-596.
  • Mehta, R.G., Barua, A.B., Olson, J.A. and Moon, R.C. (1991) Effects of retinoid glucuronides on mammary gland development in organ culture. Oncology 48: 505-509.
  • Mehta, R.G., Steele, V., Kelloff, G.J. and Moon, R.C. (1991) Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro. Anticancer Res. 11: 587-592.
  • Rao, C.V., Nayini, J. and Reddy, B.S. (1991) Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats. Proc. Soc. Exp. Biol. Med. 197: 77-84.
  • Rao, C.V., Tokumo, K., Rigotty, J., Zang, E., Kelloff, G. and Reddy, B.S. (1991) Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, -difluoromethylornithine, 16 -fluoro-5-androsten-17-one, and ellagic acid individually and in combination. Cancer Res. 51: 4528-4534.
  • Rao, C.V., Tokomo, K., Kelloff, G. and Reddy, B.S. (1991) Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats. Carcinogenesis 12: 1051-1055.
  • Ratko, T.A., Detrisac, C.J., Mehta, R.G., Kelloff, G.J. and Moon, R.C. (1991) Inhibition of rat mammary gland chemical carcinogenesis by dietary dehydroepiandrosterone or a fluorinated analogue of dehydroepiandrosterone. Cancer Res. 51: 481-486.
  • Rhodes, S.W., Hurst, R.E., Rollins, S.A., Jones, P.L., Hemstreet, G.P., Moon, R.C., Thomas, C.F., Detrisac, C.J. and Kelloff, G.J. (1991) DNA ploidy and p21 protein levels in tissue sections as end-point markers in animal carcinogenesis trials. Biol. Monit. 1: 61-73.
  • Boone, C.W., Kelloff, G.J. and Malone, W.F. (1990) Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review. Cancer Res. 50: 2-9.
  • Greenwald, P., Nixon, D.W., Malone, W.F., Kelloff, G.J., Stern, H.R. and Witkin, K.M. (1990) Concepts in cancer chemoprevention research. Cancer 65: 1483-1490.
  • Kelloff, G.J., Malone, W.F., Boone, C.W., Sigman, C.C. and Fay, J.R. (1990) Progress in applied chemoprevention research. Semin. Oncol. 17: 438-455.
  • Ratko, T.A., Detrisac, C.J., Rao, K.V.N., Thomas, C.F., Kelloff, G.J. and Moon, R.C. (1990) Interspecies analysis of the chemopreventive efficacy of dietary -difluoromethylornithine. Anticancer Res. 10: 67-72.
  • Reddy, B.S., Nayini, J., Tokumo, K., Rigotty, J., Zang, E. and Kelloff, G. (1990) Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug, with D,L- -difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet. Cancer Res. 50: 2562-2568.
  • Steele, V.E., Kelloff, G.J., Wilkinson, B.P. and Arnold, J.T. (1990) Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents. Cancer Res. 50: 2068-2074.

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