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Chemopreventive Agent Development Research Group

Publications

View All  |  2014-2010  |  2009-2000  |  1999-1990  |  1989-1985

  • Andriole GL, Crawford ED, Grubb RL, Buys SS, Chia D, Church TR, Fouad MN, Gelmann EP, Kvale PA, Reding DJ, Weissfeld JL, Yokochi LA, O'Brien B, Clapp JD, Rathmell JM, Riley TL, Hayes RB, Kramer BS, Izmirlian G, Miller AB, Pinsky PF, Prorok PC, Gohagan JK, Berg CD; PLCO Project Team. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009 Mar 26;360:1310-1319.
    [ PubMed Abstract ]
  • Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL. Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys. 2009 Jun 15;486(2): 95-102.
    [ PubMed Abstract ]
  • Balansky R, Ganchev G, Iltcheva M, Steele VE, De Flora S. Prenatal N-acetylcysteine prevents cigarette smoke-induced lung cancer in neonatal mice. Carcinogenesis. 2009 Aug;30(8): 1398-1401.
    [ PubMed Abstract ]
  • Boman B, Kopelovich L, Siracusa LD, Zhang T, Henderson K, Cofer Z, Buchberg AM, Fields JZ, Otevrel T. A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis. Mol Carcinog. 2009 Sep;48(9):821-31.
    [ PubMed Abstract ]
  • Burgess JP, Green JS, Hill JM, Zhan Q, Lindeblad M, Lyubimov A, Kapetanovic IM, Schwartz A, Thomas BF. Identification of [14C]fluasterone metabolites in urine and feces collected from dogs after subcutaneous and oral administration of [14C]fluasterone. Drug Metab Dispos. 2009 May;37(5):1089-97.
    [ PubMed Abstract ]
  • D'Agostini F, Mastracci L, Izzotti A, Balansky R, Pennisi TM, Steele VE, De Flora S. Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice. Cancer Prev Res. 2009 Jun;2(6): 546-56.
    [ PubMed Abstract ]
  • Duncan CG, Leary RJ, Lin JC, Cummins J, Di C, Schaefer CF, Wang TL, Riggins GJ, Edwards J, Bigner D, Kopelovich L, Vogelstein B, Kinzler KW, Velculescu VE, Yan H. Identification of microbial DNA in human cancer. BMC Med Genomics. 2009 May 8;2: 22.
    [ PubMed Abstract ]
  • Dunn BK, Ryan A, Ford LG. Selenium and Vitamin E Cancer Prevention Trial: a nutrient approach to prostate cancer prevention [Review]. Recent Results Cancer Res. 2009 181:183-93.
    [ PubMed Abstract ]
  • Fay JR, Steele V, Crowell JA. Energy homeostasis and cancer prevention: The AMP-activated protein kinase. Cancer Prev Res. 2009 Apr;2(4): 301-9.
    [ PubMed Abstract ]
  • Fu H, He J, Mei F, Zhang Q, Hara Y, Ryota S, Lubet RA, Chen R, Chen DR, You M. Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E). Cancer Prev Res. 2009 Jun;2(6): 531-7.
    [ PubMed Abstract ]
  • Gorman GS, Coward L, Kerstner-Wood C, Freeman L, Hebert CD, Kapetanovic IM. In-vitro and in-vivo metabolic studies of the candidate chemopreventative pentamethylchromanol using liquid chromatography/tandem mass spectrometry. J Pharm Pharmacol. 2009 Oct;61(10): 1309-18.
    [ PubMed Abstract ]
  • Hakim AA, Barry CP, Barnes HJ, Anderson KE, Petitte J, Whitaker R, Lancaster JM, Wenham RM, Carver DK, Turbov J, Berchuck A, Kopelovich L, Rodriguez GC. Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu. Cancer Prev Res. 2009 2: 114-121. Erratum in: Cancer Prev Res ( Phila Pa ). 2009 Mar;2(3):283. Comment in: Cancer Prev Res ( Phila Pa ). 2009 Feb;2(2):97-9.
    [ PubMed Abstract ]
  • Greenwald P, Dunn BK. Landmarks in the history of cancer epidemiology. Cancer Res. 2009; Mar 15;69(6):2151-62. Erratum in: Cancer Res. 2009 Aug 15;69(16):6758.
    [ PubMed Abstract ]
  • Greenwald P, Dunn BK. Do we make optimal use of the potential of cancer prevention? [Review]. Recent Results Cancer Res. 2009 181:3-17.
    [ PubMed Abstract ]
  • Itano O, Yang K, Fan K, Kurihara N, Shinozaki H, Abe S, Jin B, Gravaghi C, Edelmann W, Augenlicht L, Kopelovich L, Kucherlapati R, Lamprecht S, Lipkin M. Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. Carcinogenesis. 2009 Nov;30(11):1923-26.
    [ PubMed Abstract ]
  • Izzotti A, Calin GA, Arrigo P, Steele VE, Croce CM, De Flora S. Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J. 2009 23: 806-12.
  • Izzotti A, Calin GA, Steele VE, Croce CM, De Flora S. Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light. FASEB J. 2009 23: 3243-50.
  • Izzotti A, D'Agostini F, Larghero P, Cartiglia C, Travaini G, Balansky R, Steele VE, De Flora S. Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke. Oncol Rep. 2009 Sep;22(3): 469-74.
    [ PubMed Abstract ]
  • Jackson JP, Kabirov KK, Kapetanovic IM, Lyubimov A. In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3): 263-72.
    [ PubMed Abstract ]
  • Janakiram NB, Steele VE, Rao CV. Estrogen receptor-beta as a potential target for colon cancer prevention: Chemoprevention of azoxymethane-induced colon carcinogenesis by raloxifene in F344 rats. Cancer Prev Res. 2009 Jan;2(1): 52-59.
    [ PubMed Abstract ]
  • Kadota M, Sato M, Duncan B, Ooshima A, Yang HH, Diaz-Meyer N, Gere S, Kageyama S, Fukuoka J, Nagata T, Tsukada K, Dunn BK, Wakefield LM, Lee MP. Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA. Cancer Res. 2009 Sep 15;69(18):7357-65.
    [ PubMed Abstract ]
  • Kapetanovic IM. Rapid access to preventive intervention development program in the Division of Cancer Prevention of the U.S. National Cancer Institute: an overview. Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3): 698-700.
    [ PubMed Abstract ]
  • Kapetanovic IM, Bauer KS, Tessier DM, Lindeblad MO, Zakharov AD, Lubet R, Lyubimov A. Comparison of pharmacokinetic and pharmacodynamic profiles of aspirin following oral gavage and diet dosing in rats. Chem Biol Interact. 2009 May 15;179(2-3): 233-9.
    [ PubMed Abstract ]
  • Kapetanovic IM, Crowell JA, Krishnaraj R, Zakharov A, Lindeblad M, Lyubimov A. Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs. Toxicology. 2009 Jun 16;260(1-3): 28-36.
    [ PubMed Abstract ]
  • Kelloff GJ, Choyke P, Coffey DS. Challenges in clinical prostate cancer: Role of imaging. AJR Am J Roentgenol. 2009 Jun;192(6): 1455-70.
    [ PubMed Abstract ]
  • Lubet RA, Boring D, Steele VE, Ruppert JM, Juliana MM, Grubbs CJ. Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis. Cancer Prev Res. 2009 Feb;2(2): 161-7.
    [ PubMed Abstract ]
  • Lubet RA, Yao R, Grubbs CJ, You M, Wang Y. Induced expression of drug metabolizing enzymes by preventive agents: Role of the antioxidant response element. Chem Biol Interact. 2009 Nov 10;182(1): 22-8.
    [ PubMed Abstract ]
  • Lee N, Laine AF, Marquez G, Levsky JM, Gohagan JK. Potential of computer-aided diagnosis to improve CT lung cancer screening. IEEE Reviews in Biomedical Engineering. 2009 Dec 2:136-146.
  • Miller JH, Kramer BS, Kreimer AR, Prorok PC, Xu J-L, Baker SG, Fagerstrom R, Riley TL, Clapp JD, Berg CD, Gohagan JK, Andriole GL, Chia D, Church TR, Crawford ED, Fouad MN, Gelmann EP, Lamerato L, Reding DJ, Schoen RE. Cumulative incidence of false-positive results in repeated, multi-modality cancer screening. Ann Fam Med. 2009 May/June 7(3):212-222.
    [ PubMed Abstract ]
  • Rao CV, Steele VE, Stoner GD, Conney AH. Bandaru S. Reddy: In memoriam (1930-2009). Cancer Prev Res. 2009 2: 912-13.
  • Rao CV, Steele VE, Swamy MV, Patlolla JM, Guruswamy S, Kopelovich L. Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats. Cancer Res. 2009 Oct 15;69(20): 8175-82.
    [ PubMed Abstract ]
  • Steele VE, Rao CV, Zhang Y, Patlolla J, Boring D, Kopelovich L, Juliana MM, Grubbs CJ, Lubet RA. Chemopreventive efficacy of naproxen and nitric oxide-naproxen in rodent models of colon, urinary bladder, and mammary cancers. Cancer Prev Res. 2009 Nov;2(11): 951-6.
    [ PubMed Abstract ]
  • Vydelingum NA (member of the HHS Interagency Workgroup for the NHQR/NHDR). 2008 National Healthcare Disparities Report. Rockville, MD: U.S. Department of Health and Human Services, Agency for Healthcare Research and Quality; March 2009. AHRQ Pub. No. 09-0002.
  • Wang Y, Wen W, Yi Y, Zhang Z, Lubet RA, You M. Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer. Cancer Prev Res. 2009 Dec;2(12): 1059-64.
    [ PubMed Abstract ]
  • Wang Y, Zhang Z, Garbow JR, Rowland DJ, Lubet RA, Sit D, Law F, You M. Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. Cancer Prev Res. 2009 Jul;2(7): 634-40.
    [ PubMed Abstract ]
  • Yin Y, Yuan H, Zeng X, Kopelovich L, Glazer RI. Inhibition of peroxisome proliferator-activated receptor gamma increases estrogen receptor-dependent tumor specification. Cancer Res. 2009 Jan 15;69(2): 687-94.
    [ PubMed Abstract ]
  • Alyaqoub FS, Liu Y, Tao L, Steele VE, Lubet RA, Pereira MA . Modulation by bexarotene of mRNA expression of genes in mouse lung tumors. Mol Carcinog. 2008 Mar;47(3): 165-71.
    [ PubMed Abstract ]
  • Clapper ML, Gary MA, Coudry RA, Litwin S, Chang WC, Devarajan K, Lubet RA, Cooper HS. 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis. Inflamm Bowel Dis. 2008 Oct;14(10): 1341-47.
    [ PubMed Abstract ]
  • D'Agostini F, Balansky R, Steele VE, Ganchev G, Pesce C, De Flora S. Preneoplastic and neoplastic lesions in the lung, liver and urinary tract of mice exposed to environmental cigarette smoke and UV light since birth. Int J Cancer. 2008 Dec 1;123(11): 2497-2502.
    [ PubMed Abstract ]
  • De Flora S, D'Agostini F, Balansky R, Camoirano A, Cartiglia C, Longobardi M, Travaini G, Steele VE, Pesce C, Izzotti A. High susceptibility of neonatal mice to molecular, biochemical and cytogenetic alterations induced by environmental cigarette smoke and light. Mutat Res. 2008 Jul-Aug;659(1-2): 137-46.
    [ PubMed Abstract ]
  • Dupre A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008 Feb;4(2): 119-25.
    [ PubMed Abstract ]
  • Furimsky AM, Green CE, Sharp LE, Catz P, Adjei AA, Parman T, Kapetanovic IM, Weinshilboum RM, Iyer LV. Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1. Drug Metab Dispos. 2008 Jan;36(1): 129-36.
    [ PubMed Abstract ]
  • Garbow JR, Wang M, Wang Y, Lubet RA, You M. Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging. Clin Cancer Res. 2008 Mar 1;14(5): 1363-67.
    [ PubMed Abstract ]
  • Guruswamy S, Swamy MV, Choi CI, Steele VE, Rao CV. S-adenosyl L-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture. Int J Cancer. 2008 Jan 1;122(1): 25-30.
    [ PubMed Abstract ]
  • Izzotti A, D'Agostini F, Balansky R, Degan P, Pennisi TM, Steele VE, De Flora S. Exposure of mice to cigarette smoke and/or light causes DNA alterations in heart and aorta. Mutat Res. 2008 Sep 26;644(1-2): 38-42.
    [ PubMed Abstract ]
  • Janakiram NB, Cooma I, Mohammed A, Steele VE, Rao CV. Beta-ionone inhibits colonic aberrant crypt foci formation in rats, suppresses cell growth, and induces retinoid X receptor-alpha in human colon cancer cells. Mol Cancer Ther. 2008 Jan;7(1): 181-90.
    [ PubMed Abstract ]
  • Janakiram NB, Indranie C, Malisetty SV, Jagan P, Steele VE, Rao CV. Chemoprevention of colon carcinogenesis by oleanolic acid and its analog in male F344 rats and modulation of COX-2 and apoptosis in human colon HT-29 cancer cells. Pharm Res. 2008 Sep;25(9): 2151-7.
    [ PubMed Abstract ]
  • Johnson WD, Morrissey RL, Kapetanovic I, Crowell JA, McCormick DL. Subchronic oral toxicity studies of Se-methylselenocysteine, an organoselenium compound for breast cancer prevention. Food Chem Toxicol. 2008 Mar;46(3): 1068-78.
    [ PubMed Abstract ]
  • Kabirov KK, Kapetanovic IM, Lyubimov AV. Direct determination of selenium in rat blood plasma by Zeeman atomic absorption spectrometry. Chem Biol Interact. 2008 Jan 30;171(2): 152-8.
    [ PubMed Abstract ]
  • Kapetanovic IM. Computer-aided drug discovery and development (CADDD): In silico-chemico-biological approach. Chem Biol Interact. 2008 Jan 30;171(2): 165-76.
    [ PubMed Abstract ]
  • Kapetanovic IM, Lyubimov A: Analytical Chemistry Methods- Developments and Validation. in Gad SC (ed) Preclinical Development Handbook: ADME and Biopharmaceutical Properties, Wiley-Interscience, ISBN 978-0-470-24847-8 (2008), Hoboken, NJ, Ch. 5, pp. 151-210.
    [ Handbook Information Link Exit Disclaimer ]
  • Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjoblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, Kopelovich L, Papadopoulos N, Pennacchio LA, Wang TL, Markowitz SD, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci USA . 2008 Oct 21;105(42): 16224-9.
    [ PubMed Abstract ]
  • Lubet RA, Fischer SM, Steele VE, Juliana MM, Desmond R, Grubbs CJ. Rosiglitazone, a PPAR gamma agonist: Potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers. Int J Cancer. 2008 Nov 15;123(10): 2254-9.
    [ PubMed Abstract ]
  • Lubet RA, Szabo E, Christov K, Bode AM, Ericson ME, Steele VE, Juliana MM, Grubbs CJ. Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes. Mol Cancer Ther. 2008 Apr;7(4): 972-9.
    [ PubMed Abstract ]
  • Martin-Jimenez T, Lindeblad M, Kapetanovic IM, Chen Y, Lyubimov A. Comparing pharmacokinetic and pharmacodynamic profiles in female rats orally exposed to lovastatin by gavage versus diet. Chem Biol Interact. 2008 Jan 30;171(2): 142-51.
    [ PubMed Abstract ]
  • Mehta RG, Naithani R, Huma L, Hawthorne M, Moriarty RM, McCormick DL, Steele VE, Kopelovich L. Efficacy of chemopreventive agents in mouse mammary gland organ culture (MMOC) model: a comprehensive review. Curr Med Chem. 2008;15(27): 2785-825.
    [ PubMed Abstract ]
  • Micale RT, D'Agostini F, Steele VE, La Maestra S, De Flora S. Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke. Curr Cancer Drug Targets. 2008 Dec;8(8): 703-8.
    [ PubMed Abstract ]
  • Pearce VP, Sherrell J, Lou Z, Kopelovich L, Wright WE, Shay JW. Immortalization of epithelial progenitor cells mediated by resveratrol. Oncogene. 2008 Apr 10;27(17): 2365-74.
    [ PubMed Abstract ]
  • Rao CV, Joseph S, Gao L, Patlolla JM, Choi CI, Kopelovich L, Steele VE, Rigas B. Pharmaco-kinetic and pharmacodynamic study of NO-donating aspirin in F344 rats. Int J Oncol. 2008 33: 799-805.
    [ PubMed Abstract ]
  • Rao CV, Swamy MV, Patlolla JM, Kopelovich L. Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice. Cancer Res. 2008 Sep 15;68(18): 7670-5.
    [ PubMed Abstract ]
  • Reed GA, Sunega JM, Sullivan DK, Gray JC, Mayo MS, Crowell JA, Hurwitz A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10): 2619-24.
    [ PubMed Abstract ]
  • Reid JM, Mandrekar SJ, Carlson EC, Harmsen WS, Green EM, McGovern RM, Szabo E, Ames MM, Boring D, Limburg PJ. Comparative bioavailability of sulindac in capsule and tablet formulations. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3): 674-9.
    [ PubMed Abstract ]
  • Rosenfeld S, Kapetanovic IM. Systems biology and cancer prevention: All options on the table. Gene Regul Syst Bio. 2008 Oct 10;2: 307-19.
    [ PubMed Abstract ]
  • Stewart J, Ware J, Boysen C, Gulati S, Zhou Z, Rosenfeld S, Kopelovich L, Kennedy AR. Effects of selenomethionine on the gene expression profile of cloned human prostate cancer cells representing a phenotypic continuum of cancer progression. Nutr Cancer. 2008; 60(6): 826-36.
    [ PubMed Abstract ]
  • Tang X, Kim AL, Kopelovich L, Bickers DR, Athar M. Cyclooxygenase-2 inhibitor Nimesulide blocks ultraviolet -induced photocarcinogenesis in SKH-1 Hairless Mice. Photochem Photobiol. 2008 Mar-Apr;84(2): 522-7.
    [ PubMed Abstract ]
  • Vareed SK, Kakarala M, Ruffin MT, Crowell JA, Normolle DP, Djuric Z, Brenner DE . Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6): 1411-7.
    [ PubMed Abstract ]
  • Wang Y, Zhang Z, Lu Y, Yao R, Jia D, Wen W, LaRegina M, Crist K, Lubet R, You M. Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation. Mol Cancer Res. 2008 6: 99-109.
    [ PubMed Abstract ]
  • Woditschka S, Haag JD, Mau B, Lubet RA, Gould MN. Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model. Breast Cancer Res. 2008;10(1): R18.
    [ PubMed Abstract ]
  • Yang K, Lamprecht SA, Shinozaki H, Fan K, Yang W, Newmark HL, Kopelovich L, Edelmann W, Jin B, Gravaghi C, Augenlicht L, Kucherlapati R, Lipkin M. Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. J Nutr. 2008 Sep;138(9): 1658-63.
    [ PubMed Abstract ]
  • Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A. One-hit effects in cancer: Altered proteome of morphologically normal colon crypts in familial adenomatous polyposis. Cancer Res. 2008 Sep 15;68(18): 7579-86.
    [ PubMed Abstract ]
  • Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR, Kim AL. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):274-83.
    [ PubMed Abstract ]
  • Balansky R, Ganchev G, Iltcheva M, Steele VE, D'Agostini F, De Flora S. Potent carcinogenicity of cigarette smoke in mice exposed early in life. Carcinogenesis. 2007 Oct;28(10):2236-43. Epub 2007 May 23.
    [ PubMed Abstract ]
  • Chalut KJ, Kresty LA, Pyhtila JW, Nines R, Baird M, Steele VE, Wax A. In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometry. Cancer Epidemiol Biomarkers Prev 16 (2): 223-7, 2007.
    [ PubMed Abstract ]
  • Crowell JA, Steele VE, Fay JR. Targeting the AKT protein kinase for cancer chemoprevention. Mol Cancer Ther. 2007 Aug;6(8):2139-48. Review.
    [ PubMed Abstract ]
  • Doppalapudi RS, Riccio ES, Rausch LL, Shimon JA, Lee PS, Mortelmans KE, Kapetanovic IM, Crowell JA, Mirsalis JC. Evaluation of chemopreventive agents for genotoxic activity. Mutat Res. 2007 May 18;629(2):148-60.
    [ PubMed Abstract ]
  • Elmore E, Jain A, Siddiqui S, Tohidian N, Meyskens FL, Steele VE, Redpath JL. Development and characteristics of a human cell assay for screening agents for melanoma prevention. Melanoma Res 17 (1): 42-50, 2007.
    [ PubMed Abstract ]
  • Gorman GS, Coward L, Kerstner-Wood C, Cork L, Kapetanovic IM, Brouillette WJ, Muccio DD. In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid. Drug Metab Dispos. 2007 Jul;35(7):1157-64.
    [ PubMed Abstract ]
  • Horn TL, Cwik MJ, Morrissey RL, Kapetanovic I, Crowell JA, Booth TD, McCormick DL. Oncogenicity evaluation of resveratrol in p53((+/-)) (p53 knockout) mice. Food Chem Toxicol. 45:55-63, 2007
    [ PubMed Abstract ]
  • Horn TL, Torres KE, Naylor JM, Cwik MJ, Detrisac CJ, Kapetanovic IM, Lubet RA, Crowell JA, McCormick DL. Subchronic toxicity and toxicogenomic evaluation of tamoxifen citrate + bexarotene in female rats. Toxicol Sci. 2007 Oct;99(2):612-27. Epub 2007 Jul 14.
    [ PubMed Abstract ]
  • Li L, Tao L, Lubet RA, Steele VE, Pereira MA. Modulation by budesonide of a CpG endonuclease in mouse lung tumors. Carcinogenesis. 2007 Jul;28(7):1499-503. Epub 2007 Mar 14.
    [ PubMed Abstract ]
  • Lubet RA, Yang CS, Lee MJ, Hara Y, Kapetanovic IM, Crowell JA, Steele VE, Juliana MM, Grubbs CJ. Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols. Mol Cancer Ther. 2007 Jul;6(7):2022-8.
    [ PubMed Abstract ]
  • McCormick DL, Johnson WD, Bosland MC, Lubet RA, Steele VE. Chemoprevention of rat prostate carcinogenesis by soy isoflavones and by Bowman-Birk inhibitor. Nutr Cancer. 2007;57(2):184-93.
    [ PubMed Abstract ]
  • McCormick DL, Johnson WD, Haryu TM, Bosland MC, Lubet RA, Steele VE. Null effect of dietary restriction on prostate carcinogenesis in the Wistar-Unilever rat. Nutr Cancer. 2007;57(2):194-200.
    [ PubMed Abstract ]
  • McCormick DL, Johnson WD, Kozub NM, Rao KV, Lubet RA, Steele VE, Bosland MC. Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone. Carcinogenesis. 2007 Feb;28(2):398-403. Epub 2006 Sep 3.
    [ PubMed Abstract ]
  • Pereira MA, Tao L, Liu Y, Li L, Steele VE, Lubet RA. Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int J Cancer 120 (5): 1150-3, 2007.
    [ PubMed Abstract ]
  • Ware JH, Zhou Z, Guan J, Kennedy AR, Kopelovich L. Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agents. Anticancer Res 27 (1A): 1-16, 2007.
    [ PubMed Abstract ]
  • Ali IU, Xiao Z, Malone W, Smith M, Conrads TP, Veenstra TD, Greenwald P, Luke BT, McLarty JW. Plasma proteomic profiling: search for lung cancer diagnostic and early detection markers. Oncol Rep 15 (5): 1367-1372, 2006.
    [ PubMed Abstract ]
  • Alyaqoub FS, Tao L, Kramer PM, Steele VE, Lubet RA, Gunning WT, Pereira MA. Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT). Carcinogenesis, 2006, (in press).
    [ PubMed Abstract ]
  • Arif JM, Dresler C, Clapper ML, Gairola CG, Srinivasan C, Lubet RA, Gupta RC. Lung DNA adducts detected in human smokers are unrelated to typical polyaromatic carcinogens. Chem Res Toxicol 19 (2): 295-299, 2006.
    [ PubMed Abstract ]
  • Athar M, Tang X, Lee JL, Kopelovich L, Kim AL. Hedgehog signalling in skin development and cancer. Exp Dermatol 15 (9): 667-677, 2006.
    [ PubMed Abstract ]
  • Balansky R, D'Agostini F, Ganchev G, Izzotti A, Di Marco B, Lubet RA, Zanesi N, Croce CM, De Flora S. Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine. Proc Natl Acad Sci USA 103 (20): 7823-7828, 2006.
    [ PubMed Abstract ]
  • Boocock DJ, Patel KR, Faust GE, Normolle DP, Marczylo TH, Crowell JA, Brenner DE, Booth TD, Gescher A, Steward WP. Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, (in press).
    [ PubMed Abstract ]
  • Brill SS, Furimsky AM, Ho MN, Furniss MJ, Li Y, Green AG, Bradford WW, Green CE, Kapetanovic IM, Iyer LV. Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms. J Pharm Pharmacol 58 (4): 469-479, 2006.
    [ PubMed Abstract ]
  • Burgess JP, Wintermute JS, Thomas BF, Kapetanovic IM. Complete (1)H and (13)C assignments of fluorinated analogs of dehydroepiandrosterone. Magn Reson Chem 44 (11): 1051-3, 2006.
    [ PubMed Abstract ]
  • Chien Y, Kim S, Bumeister R, Loo YM, Kwon SW, Johnson CL, Balakireva MG, Romeo Y, Kopelovich L, Gale M, Jr., Yeaman C, Camonis JH, Zhao Y, White MA. RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. Cell 127 (1): 157-70, 2006.
    [ PubMed Abstract ]
  • Chow HH, Hakim IA, Vining DR, Crowell JA, Cordova CA, Chew WM, Xu MJ, Hsu CH, Ranger-Moore J, Alberts DS. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev 15 (12): 2473-6, 2006.
    [ PubMed Abstract ]
  • Crowell JA, Page JG, Levine BS, Tomlinson MJ, Hebert CD. Indole-3-carbinol, but not its major digestive product 3,3'-diindolylmethane, induces reversible hepatocyte hypertrophy and cytochromes P450. Toxicol Appl Pharmacol. 211 (2): 115-123, 2006.
    [ PubMed Abstract ]
  • Gerhauser C, Bartsch H, Crowell J, Flora SD, D'Incalci M, Dittrich C, Frank N, Mihich E, Steffen C, Tortora G, Gescher A. Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising Phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005. Eur J Cancer 42 (10): 1338-1343, 2006.
    [ PubMed Abstract ]
  • Grubbs CJ, Lubet RA, Atigadda VR, Christov K, Deshpande AM, Tirmal V, Xia G, Bland KI, Eto I, Brouillette WJ, Muccio DD. Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers. Carcinogenesis 27 (6): 1232-1239, 2006.
    [ PubMed Abstract ]
  • Huang Y, Yan J, Lubet R, Kensler TW, Sutter TR. Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione. Physiol Genomics 24 (2): 144-153, 2006.
    [ PubMed Abstract ]
  • Johnson WD, Dooley L, Morrissey RL, Arp L, Kapetanovic I, Crowell JA, McCormick DL. Oncogenicity evaluations of chemopreventive soy components in p53((+/-)) (p53 knockout) mice. Int J Toxicol. 25 (3): 219-228, 2006.
    [ PubMed Abstract ]
  • Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athar M. Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways. Exp Dermatol 15 (7): 538-546, 2006.
    [ PubMed Abstract ]
  • Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 6: 10, 2006.
    [ PubMed Abstract ]
  • Lu Y, Yao R, Yan Y, Wang Y, Hara Y, Lubet RA, You M. A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice. Cancer Res 66 (4): 1956-1963, 2006.
    [ PubMed Abstract ]
  • Lubet RA, Christov K, You M, Yao R, Steele VE, End DW, Juliana MM, Grubbs CJ. Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations. Mol.Cancer Ther  5 (4): 1073-1078, 2006.
    [ PubMed Abstract ]
  • McCormick DL, Johnson WD, Kozub NM, Rao KV, Lubet RA, Steele VE, Bosland MC. Chemoprevention of rat prostate carcinogenesis by dietary 16{alpha}-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone. Carcinogenesis, 2006, (in press).
    [ PubMed Abstract ]
  • Mehta SA, Christopherson KW, Bhat-Nakshatri P, Goulet RJ, Jr., Broxmeyer HE, Kopelovich L, Nakshatri H. Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion. Oncogene, 2006, (in press).
    [ PubMed Abstract ]
  • Ouyang N, Williams JL, Tsioulias GJ, Gao J, Iatropoulos MJ, Kopelovich L, Kashfi K, Rigas B. Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model. Cancer Res. 66 (8): 4503-4511, 2006.
    [ PubMed Abstract ]
  • Pereira MA, Kramer PM, Nines R, Liu Y, Alyaqoub FS, Gunning WT, Steele VE, Lubet RA. Prevention of mouse lung tumors by targretin. Int J Cancer 118 (9): 2359-2362, 2006.
    [ PubMed Abstract ]
  • Rao CV, Reddy BS, Steele VE, Wang CX, Liu X, Ouyang N, Patlolla JM, Simi B, Kopelovich L, Rigas B. Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets. Mol Cancer Ther 5 (6): 1530-1538, 2006.
    [ PubMed Abstract ]
  • Reddy BS, Wang CX, Kong AN, Khor TO, Zheng X, Steele VE, Kopelovich L, Rao CV. Prevention of azoxymethane-induced colon cancer by combination of low doses of atorvastatin, aspirin, and celecoxib in F 344 rats. Cancer Res 66 (8): 4542-4546, 2006.
    [ PubMed Abstract ]
  • Reed GA, Arneson DW, Putnam WC, Smith HJ, Gray JC, Sullivan DK, Mayo MS, Crowell JA, Hurwitz A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. Cancer Epidemiol Biomarkers Prev 15 (12): 2477-81, 2006.
    [ PubMed Abstract ]
  • Sharma S, Gao P, Steele VE. The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model. Carcinogenesis 27 (8): 1721-1727, 2006.
    [ PubMed Abstract ]
  • Steele VE, Arnold JT, Lei H, Izmirlian G, Blackman MR. Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells. Anticancer Res 26 (5A): 3205-15, 2006.
    [ PubMed Abstract ]
  • Swamy MV, Patlolla JM, Steele VE, Kopelovich L, Reddy BS, Rao CV. Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice. Cancer Res 66 (14): 7370-7377, 2006.
    [ PubMed Abstract ]
  • Verschoyle RD, Greaves P, Cai H, Borkhardt A, Broggini M, D'Incalci M, Riccio E, Doppalapudi R, Kapetanovic IM, Steward WP, Gescher AJ. Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. Cancer Chemother.Pharmacol. 57 (1): 1-6, 2006.
    [ PubMed Abstract ]
  • Wang Y, Yao R, Maciag A, Grubbs CJ, Lubet RA, You M. Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide. Mol Cancer Ther  5 (4): 1060-1072, 2006.
    [ PubMed Abstract ]
  • Wang Y, Zhang Z, Lubet RA, You M. A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. Oncogene 25 (8): 1277-1280, 2006.
    [ PubMed Abstract ]
  • Wang Y, Zhang Z, Yao R, Jia D, Wang D, Lubet RA, You M. Prevention of lung cancer progression by bexarotene in mouse models. Oncogene 25 (9): 1320-1329, 2006.
    [ PubMed Abstract ]
  • Ware JH, Zhou Z, Kopelovich L, Kennedy AR. Evaluation of cancer chemopreventive agents using clones derived from a human prostate cancer cell line. Anticancer Res 26 (6B): 4177-83, 2006.
    [ PubMed Abstract ]
  • Woditschka S, Haag JD, Waller JL, Monson DM, Hitt AA, Brose HL, Hu R, Zheng Y, Watson PA, Kim K, Lindstrom MJ, Mau B, Steele VE, Lubet RA, Gould MN. Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas. Cancer Res  66 (13): 6884-6891, 2006.
    [ PubMed Abstract ]
  • Yan Y, Lu Y, Wang M, Vikis H, Yao R, Wang Y, Lubet RA, You M. Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer. Mol Cancer Res 4 (12): 971-81, 2006.
    [ PubMed Abstract ]
  • Yan Y, Wang Y, Tan Q, Hara Y, Yun TK, Lubet RA, You M. Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice. Neoplasia 8 (1): 52-58, 2006.
    [ PubMed Abstract ]
  • Yao R, Wang Y, Lu Y, Lemon WJ, End DW, Grubbs CJ, Lubet RA, You M. Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: Role of Ha-ras mutations and use of microarray analysis to identify potential targets. Carcinogenesis 27 (7): 1420-31, 2006.
    [ PubMed Abstract ]
  • Zhang Z, Wang Y, Yao R, Li J, Lubet RA, You M. p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer. Mol Cancer Res  4 (6): 401-410, 2006.
    [ PubMed Abstract ]
  • Catz P, Shinn W, Kapetanovic IM, Kim H, Kim M, Jacobson EL, Jacobson MK, Green CE: Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chrom. B Analyt Technol Biomed Life Sci. 829:123-35, 2005.
    [ PubMed Abstract ]
  • Crist, K.A., Zhang, Z., You, M., Gunning, W.T., Conran, P.B., Steele, V.E., and Lubet R.A. Characterization of rat ovarian adenocarcinomas developed in response to direct instillation of 7,12-dimethyldenz[a]anthracene (DMBA) coated suture. Carcinogenesis 26:951-957, 2005.
    [ PubMed Abstract ]
  • Elmore, E., Siddiqui, S., Navidi, M., Steele, V.E., and Redpath, L. Correlation of In Vitro chemopreventive efficacy data from the human epidermal cell assay with animal efficacy data and clinical trial plasma levels. J Cell Biochem, 95:571-588, 2005.
    [ PubMed Abstract ]
  • Horn TL, Long L, Cwik MJ, Morrissey RL, Kapetanovic IM, McCormick DL: Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic administration of farnesol. Chemico-Biol. Interact. 152:79-99, 2005.
    [ PubMed Abstract ]
  • Lubet, R.A., Christov, K., Nunez, N.P., Hursting, S.D., Steele, V.E., Juliana, M.M., Eto, I., Grubbs, C.J. Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis. Carcinogenesis. 26(2):441-448, 2005.
    [ PubMed Abstract ]
  • Lubet, R.A., Huebner, K., Fong, L.Y.Y., Altieri, D.C., Steele, V.E., Kopelovich, L., Kavanaugh, C., Juliana, M.M., Soong, S., and Grubbs, C.J. N-Butyl-N(4 hydroxybutyl)-nitrosamine (OH-BBN) - induced urinary bladder cancers in mice: Characterization of FHIT, survivin expression, and chemoprevention effects of indomethacin. Carcinogenesis 26(3): 571-578, 2005.
    [ PubMed Abstract ]
  • Raju, J., Swamy, M.V., Cooma, I., Patlolla, J.M.R., Pittman, B., Reddy, B.S., Steele, V.E., and Rao, C.V. Low doses of beta-carotene and lutein inhibit AOM-induced rat colonic ACF formation but high doses augment ACF incidence. Int J Cancer. 113(5):798-802, 2005.
    [ PubMed Abstract ]
  • Simeone, A-M, Deng, C-X, Kelloff, G.J., Steele, V.E., Johnson, M.M., and Tari, A.M. Inhibitory effects of N-(4-hydroxyphenyl)retinamide and other phenylretinamides against BRCA-1 mutated breast cancer cells. Carcinogenesis, 26:1000-1007, 2005.
    [ PubMed Abstract ]
  • Wax, A., Pyhtila, J.W., Graf, R.N. Graf, Nines, R., Boone, C.W., Dasari, R.R., Feld, M.S., Steele, V.E., and Stoner, G.D. Prospective grading of neoplastic change in rat esophagus using angle-resolve low coherance interferometry. Journal of Miomedical Optics 10(5): 051604-01-10, 2005.
    [ PubMed Abstract ]
  • Almahmeed T, Boyle JO, Cohen EG, Carew JF, Du B, Altorki NK, Kopelovich L, Fang JL, Lazarus P, Subbaramaiah K, Dannenberg AJ. (2004) Benzo[a]pyrene phenols are more potent inducers of CYPlAl, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. Carcinogenesis. Jan 16
    [ PubMed Abstract ]
  • Bonner AE, Lemon WJ, Devereux TR, Lubet RA, You M. (2004) Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. Oncogene. Feb 5;23(5):1166-76.
    [ PubMed Abstract ]
  • Cope MB, Steele VE, Lubet RA, Eto I, Juliana MM, Hill DL, Grubbs CJ. (2004) Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer prevention. Oncol Rep. Feb;11(2):465-9.
    [ PubMed Abstract ]
  • Estensen RD, Jordan MM, Wiedmann TS, Galbraith AR, Steele VE, Wattenberg LW. (2004) Effect of chemopreventive agents on separate stages of progression of benzo[a]pyrene induced lung tumors in A/J mice. Carcinogenesis. Feb;25(2):197-201.
    [ PubMed Abstract ]
  • Kapetanovic IM, Rosenfeld S, Izmirlian G: Overview of commonly used bioinformatics methods and their applications. In: Umar A, Kapetanovic IM, Khan J (eds) The Applications of Bioinformatics in Cancer Detection, Annals of the New York Academy of Sciences, New York, New York, 1020: 10-21, 2004.
  • Kapetanovic IM, Umar A, Khan J: Proceedings of the applications of bioinformatics in cancer detection (ABCD) workshop Exit Disclaimer . In: Umar A, Kapetanovic IM, Khan J (eds) The Applications of Bioinformatics in Cancer Detection, Annals of the New York Academy of Sciences, New York, New York, 1020: 1-9, 2004.
  • Posner GH, Jeona HB, Sarjeanta A, Riccio ES, Doppalapudi RS, Kapetanovic IM, Sahad U, Dolane P, Kensler TW: Low-calcemic, efficacious, 1_,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry. Steroids 69: 757-762, 2004.
  • Tao L, Wang W, Kramer PM, Lubet RA, Steele VE, Pereira MA. (2004) Modulation of DNA hypomethylation as a surrogate endpoint biomarker for chemoprevention of colon cancer. Mol Carcinog. Feb;39(2):79-84.
    [ PubMed Abstract ]
  • Umar A, Kapetanovic IM, Khan J (eds) The Applications of Bioinformatics in Cancer Detection Exit Disclaimer , Annals of the New York Academy of Sciences, New York, New York, v. 1020, pp. 1-277, 2004.
  • Williams JL, Kashfi K, Ouyang N, del Soldato P, Kopelovich L, Rigas B. (2004) NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice. Biochem Biophys Res Commun. Jan 16;313(3):784-8.
    [ PubMed Abstract ]
  • Balansky RM, Izzotti A, D'Agostini F, Camoirano A, Bagnasco M, Lubet RA, De Flora S. (2003) Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice. Carcinogenesis. Sep;24(9):1525-32.
    [ PubMed Abstract ]
  • Chang PY, Mirsalis J, Riccio ES, Bakke JP, Lee PS, Shimon J, Phillips S, Fairchild D, Hara Y, Crowell JA. (2003) Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E. Environ Mol Mutagen. 41(1):43-54.
    [ PubMed Abstract ]
  • Chow HH, Cai Y, Hakim IA, Crowell JA, Shahi F, Brooks CA, Dorr RT, Hara Y, Alberts DS. (2003) Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res. Aug 15;9(9):3312-9.
    [ PubMed Abstract ]
  • Christov K, Ikui A, Shilkaitis A, Green A, Yao R, You M, Grubbs C, Steele V, Lubet R, Weinstein IB. (2003) Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors. Breast Cancer Res Treat. 77(3):253-64.
    [ PubMed Abstract ]
  • Christov KT, Shilkaitis AL, Kim ES, Steele VE, Lubet RA. (2003 ) Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours. Eur J Cancer. 39(2):230-9.
    [ PubMed Abstract ]
  • Crowell JA, Steele VE, Sigman CC, Fay JR. (2003) Is inducible nitric oxide synthase a target for chemoprevention? Mol Cancer Ther. Aug;2(8):815-23.
    [ PubMed Abstract ]
  • Crowell JA, Steele VE. (2003) AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment. J Natl Cancer Inst. 95(4):252-3.
    [No abstract available.]
  • Decensi A, Veronesi U, Miceli R, Johansson H, Mariani L, Camerini T, Di Mauro MG, Cavadini E, De Palo G, Costa A, Perloff M, Malone WF, Formelli F. (2003) Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide. Clin Cancer Res. Oct 15;9(13):4722-9.
    [ PubMed Abstract ]
  • De Flora S, Balansky RM, D'Agostini F, Izzotti A, Camoirano A, Bennicelli C, Zhang Z, Wang Y, Lubet RA, You M. (2003) Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke. Cancer Res. 63(4):793-800.
    [ PubMed Abstract ]
  • De Flora S, D'Agostini F, Balansky R, Camoirano A, Bennicelli C, Bagnasco M, Cartiglia C, Tampa E, Longobardi MG, Lubet RA, Izzotti A. (2003) Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis. Mutat Res. 523-524:237-52.
    [ PubMed Abstract ]
  • Ding H, Han C, Gibson-D'Ambrosio R, Steele VE, D'Ambrosio SM. (2003) Piroxicam selectively inhibits the growth of premalignant and malignant human oral cell lines by limiting their progression through the S phase and reducing the levels of cyclins and AP-1. Int J Cancer. Dec 10;107(5):830-6.
    [ PubMed Abstract ]
  • Diwadkar-Navsariwala V, Novotny JA, Gustin DM, Sosman JA, Rodvold KA, Crowell JA, Stacewicz-Sapuntzakis M, Bowen PE. (2003) A physiological pharmacokinetic model describing the disposition of lycopene in healthy men. J Lipid Res. Oct;44(10):1927-39.
    [ PubMed Abstract ]
  • Fischer SM, Conti CJ, Viner J, Aldaz CM, Lubet RA. (2003) Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. Carcinogenesis. May;24(5):945-52.
    [ PubMed Abstract ]
  • Gunning WT, Kramer PM, Lubet RA, Steele VE, End DW, Wouters W, Pereira MA. (2003) Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777. Clin Cancer Res. May;9(5):1927-30.
    [ PubMed Abstract ]
  • Herbert BS, Pearce VP, Hynan LS, LaRue DM, Wright WE, Kopelovich L, Shay JW. (2003) A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells. Cancer Res. Apr 15;63(8):1914-9.
    [ PubMed Abstract ]
  • Hu Z, Bonifas JM, Aragon G, Kopelovich L, Liang Y, Ohta S, Israel MA, Bickers DR, Aszterbaum M, Epstein EH Jr. (2003) Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors. Cancer Res. 63(5):923-8.
    [ PubMed Abstract ]
  • Kopelovich L, Crowell JA, Fay JR. (2003) The epigenome as a target for cancer chemoprevention. J Natl Cancer Inst. Dec 3;95(23):1747-57. Review.
    [ PubMed Abstract ]
  • Korytko PJ, Rodvold KA, Crowell JA, Stacewicz-Sapuntzakis M, Diwadkar-Navsariwala V, Bowen PE, Schalch W, Levine BS. (2003) Pharmacokinetics and tissue distribution of orally administered lycopene in male dogs. J Nutr. Sep;133(9):2788-92.
    [ PubMed Abstract ]
  • Lee JL, Mukhtar H, Bickers DR, Kopelovich L, Athar M. (2003) Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol Appl Pharmacol. Nov 1;192(3):294-306. Review.
    [ PubMed Abstract ]
  • Li M, Ren S, Tilli MT, Flaws JA, Lubet R, Grubbs CJ, Furth PA. (2003) Chemoprevention of mammary carcinogenesis in a transgenic mouse model by alpha-difluoromethylornithine (DFMO) in the diet is associated with decreased cyclin D1 activity. Oncogene. May 1;22(17):2568-72.
    [ PubMed Abstract ]
  • Malone W, Perloff M, Crowell J, Sigman C, Higley H. (2003) Fenretinide: a prototype cancer prevention drug. Expert Opin Investig Drugs. Nov;12(11):1829-42.
    [ PubMed Abstract ]
  • Miltyk W, Craciunescu CN, Fischer L, Jeffcoat RA, Koch MA, Lopaczynski W, Mahoney C, Jeffcoat RA, Crowell J, Paglieri J, Zeisel SH. (2003) Lack of significant genotoxicity of purified soy isoflavones (genistein, daidzein, and glycitein) in 20 patients with prostate cancer. Am J Clin Nutr. 77(4):875-82.
    [ PubMed Abstract ]
  • Sabichi AL, Xu H, Fischer S, Zou C, Yang X, Steele VE, Kelloff GJ, Lotan R, Clifford JL. (2003) Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites. Clin Cancer Res. Oct 1;9(12):4606-13.
    [ PubMed Abstract ]
  • Steele VE.(2003) Current mechanistic approaches to the chemoprevention of cancer. J Biochem Mol Biol. 36(1):78-81.
    [ PubMed Abstract ]
  • Steele VE, Hawk ET, Viner JL, Lubet RA. (2003) Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat Res. 523-524:137-44.
    [ PubMed Abstract ]
  • Swezey RR, Aldridge DE, LeValley SE, Crowell JA, Hara Y, Green CE. (2003) Absorption, tissue distribution and elimination of 4-[(3)h]-epigallocatechin gallate in beagle dogs. Int J Toxicol. May-Jun;22(3):187-93.
    [ PubMed Abstract ]
  • Takimoto CH, Glover K, Huang X, Hayes SA, Gallot L, Quinn M, Jovanovic BD, Shapiro A, Hernandez L, Goetz A, Llorens V, Lieberman R, Crowell JA, Poisson BA, Bergan RC. (2003) Phase I pharmacokinetic and pharmacodynamic analysis of unconjugated soy isoflavones administered to individuals with cancer. Cancer Epidemiol Biomarkers Prev. Nov;12(11 Pt 1):1213-21.
    [ PubMed Abstract ]
  • Wan XS, Zhou Z, Kennedy AR, Kopelovich L. (2003) In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells. Oncol Rep. Nov-Dec;10(6):2009-14.
    [ PubMed Abstract ]
  • Wan XS, Zhou Z, Steele V, Kopelovich L, Kennedy AR. (2003) Establishment and characterization of sublines of LNCaP human prostate cancer cells. Oncol Rep. Sep-Oct;10(5):1569-75.
    [ PubMed Abstract ]
  • Wang Y, Zhang Z, Kastens E, Lubet RA, You M. (2003) Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Res. Aug 1;63(15):4389-95.
    [ PubMed Abstract ]
  • Wax A, Yang C, Muller MG, Nines R, Boone CW, Steele VE, Stoner GD, Dasari RR, Feld MS. (2003) In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry. Cancer Res. Jul 1;63(13):3556-9.
    [ PubMed Abstract ]
  • Williams JL, Nath N, Chen J, Hundley TR, Gao J, Kopelovich L, Kashfi K, Rigas B. . (2003) Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and beta-catenin/T-cell factor signaling, nuclear factor-kappaB, and NO synthase 2 inhibition: implications for chemoprevention. Cancer Res. Nov 15;63(22):7613-8.
    [ PubMed Abstract ]
  • Yang K, Fan K, Kurihara N, Shinozaki H, Rigas B, Augenlicht L, Kopelovich L, Edelmann W, Kucherlapati R, Lipkin M. (2003) Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations. Carcinogenesis 24(3):605-611.
    [ PubMed Abstract ]
  • Yao R, Wang Y, Lubet RA, You M. (2003) Differential gene expression in chemically induced mouse lung adenomas. Neoplasia 5(1):41-52.
    [ PubMed Abstract ]
  • Zhang Z, Wang Y, Lantry LE, Kastens E, Liu G, Hamilton AD, Sebti SM, Lubet RA, You M. (2003) Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf. Oncogene. Sep 18;22(40):6257-65.
    [ PubMed Abstract ]
  • An KP, Athar M, Tang X, Katiyar SK, Russo J, Beech J, Aszterbaum M, Kopelovich L, Epstein EH Jr, Mukhtar H, Bickers DR. (2002) Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem Photobiol. 76(1):73-80.
    [ PubMed Abstract ]
  • Benkins SW, Hockett R Jr., Grizzle W, Weiss, HL, Pickens, A, Perloff, M, Malone, WF, Bland KI. (2002) Transforming growth factor-alpha: a surrogate endpoint biomarker? J Am Coll Surg 195(2):149-158.
    [ PubMed Abstract ]
  • Bloedon LT, Jeffcoat AR, Lopaczynski W, Schell MJ, Black TM, Dix KJ, Thomas BF, Albright C, Busby MG, Crowell JA, Zeisel SH. (2002) Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women. Am J Clin Nutr. 76(5):1126-37.
    [ PubMed Abstract ]
  • Busby MG, Jeffcoat AR, Bloedon LT, Koch MA, Black T, Dix KJ, Heizer WD, Thomas BF, Hill JM, Crowell JA, Zeisel SH. (2002) Clinical characteristics and pharmacokinetics of purified soy isoflavones: single-dose administration to healthy men. Am J Clin Nutr. 75:126-136.
    [ PubMed Abstract ]
  • Chen X, Li N, Wang S, Hong J, Fang M, Yousselfson J, Yang P, Newman RA, Lubet RA, Yang CS. (2002) Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. Carcinogenesis 23(12):2095-102.
    [ PubMed Abstract ]
  • Christov KT, Moon RC, Lantvit DD, Boone CW, Steele VE, Lubet RA, Kelloff GJ, Pezzuto JM. (2002) 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats. Cancer Res. 15;62(18):5178-82.
    [ PubMed Abstract ]
  • Cope MB, Steele VE, Eto I, Juliana MM, Hill DL, Grubbs CJ. (2002) Prevention of methylnitrosourea-induced mammary cancers by 9-cis-retinoic acid and/or vitamin D3. Oncol Rep. 9:533-537.
    [ PubMed Abstract ]
  • Elmore E, Siddiqui S, Desai N, Moyer MP, Steele VE, Redpath JL. (2002) The human epithelial cell cytotoxicity assay for determining tissue specific toxicity: method modifications. Methods Cell Sci.;24(4):145-53.
    [ PubMed Abstract ]
  • Gunning WT, Kramer PM, Steele VE, Pereira MA. (2002) Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res. 62(15):4199-201.
    [ PubMed Abstract ]
  • Katdare M, Kopelovich L, Telang N. (2002) Efficacy of chemopreventive agents for growth inhibition of Apc [+/-] 1638NCOL colonic epithelial cells. (2002) Int J Mol Med. 10(4):427-32.
    [ PubMed Abstract ]
  • Kavanaugh CJ, Desai KV, Calvo A, Brown PH, Couldrey C, Lubet R, Green JE. (2002) Pre-clinical applications of transgenic mouse mammary cancer models. Transgenic Res. 11(6):617-33.
    [ PubMed Abstract ]
  • Kopelovich L, Fay JR, Glazer RI, Crowell JA. (2002) Peroxisome proliferator-activated receptor modulators as potential chemopreventive agents. Mol Cancer Ther. 1:357-363.
  • Lee SK, Heo YH, Steele VE, Pezzuto JM. (2002) Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells. Anticancer Res. 22:97-102.
    [ PubMed Abstract ]
  • Madhukar BV, Dimitrov NV, Meyer-Leece C, Contreras ML, Crowell J. (2002) Inhibition of mitogen-activated protein kinase activity of human lymphocytes after oral administration of Oltipraz. Mol Cancer Ther. 1(12):1125-8.
    [ PubMed Abstract ]
  • McDoniels-Silvers AL, Nimri CF, Stoner GD, Lubet RA, You M. (2002) Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin Cancer Res. 8:1127-1138.
    [ PubMed Abstract ]
  • McDoniels-Silvers AL, Stoner GD, Lubet RA, You M. (2002) Differential expression of critical cellular genes in human lung adenocarcinomas and squamous cell carcinomas in comparison to normal lung tissues. Neoplasia. 4:141-150.
    [ PubMed Abstract ]
  • Misra RR, Hursting SD, Perkins SN, Sathyamoorthy N, Mirsalis JC, Riccio ES, Crowell JA. (2002) Genotoxicity and carcinogenicity studies of soy isoflavones. Int J Toxicol. 21(4):277-85.
    [ PubMed Abstract ]
  • Opitz OG, Harada H, Suliman Y, Rhoades B, Sharpless NE, Kent R, Kopelovich L, Nakagawa H, Rustgi AK. (2002) A mouse model of human oral-esophageal cancer. J Clin Invest. 110(6):761-9.
    [ PubMed Abstract ]
  • Pereira MA, Li Y, Gunning WT, Kramer PM, Al-Yaqoub F, Lubet RA, Steele VE, Szabo E, Tao L. (2002) Prevention of mouse lung tumors by budesonide and its modulation of biomarkers. Carcinogenesis. 2002 Jul;23(7):1185-92.
    [ PubMed Abstract ]
  • Rodriguez-Burford C, Steele VE, Anderson AS, Stockard CR, Weiss HL, Eto I, Johanning GL, Grizzle WE, Grubbs CJ. (2002) Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology. Nutr Cancer. 43(1):67-75.
    [ PubMed Abstract ]
  • Sharma S, Wilkinson BP, Gao P, Steele VE. (2002) Differential Activity of NO Synthase Inhibitors as Chemopreventive Agents in a Primary Rat Tracheal Epithelial Cell Transformation System. Neoplasia. 4:332-336.
    [ PubMed Abstract ]
  • Steele VE, Boone CW, Dauzonne D, Rao CV, Bensasson RV. (2002) Correlation between electron-donating ability of a series of 3-nitroflavones and their efficacy to inhibit the onset and progression of aberrant crypt foci in the rat colon. Cancer Res. 62(22):6506-9.
    [ PubMed Abstract ]
  • Sutter TR, He XR, Dimitrov P, Xu L, Narasimhan G, George EO, Sutter CH, Grubbs C, Savory R, Stephan-Gueldner M, Kreder D, Taylor MJ, Lubet R, Patterson TA, Kensler TW. (2002) Multiple comparisons model-based clustering and ternary pattern tree numerical display of gene response to treatment: procedure and application to the preclinical evaluation of chemopreventive agents. Mol Cancer TherDec;1(14):1283-92
    [ PubMed Abstract ]
  • Tao L, Kramer PM, Wang W, Yang S, Lubet RA, Steele VE, Pereira MA. (2002) Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. Carcinogenesis. 23(9):1447-54.
    [ PubMed Abstract ]
  • Tao L, Li Y, Wang W, Kramer PM, Gunning WT, Lubet RA, Steele VE, Pereira MA. (2002) Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors. Mol Carcinog. 35(2):93-102.
    [ PubMed Abstract ]
  • Wan XS, Serota DG, Ware JH, Crowell JA, Kennedy AR. (2002) Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrate. Nutr. Cancer 43(2):167-73.
    [ PubMed Abstract ]
  • Yao R, Wang Y, Lubet RA, You M. (2002) Differentially expressed genes associated with mouse lung tumor progression. Oncogene. 22;21(37):5814-21.
    [ PubMed Abstract ]
  • Zhang Z, Li J, Lantry LE, Wang Y, Wiseman RW, Lubet RA, You M. (2002) p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas. Cancer Res. 62:3024-3029.
    [ PubMed Abstract ]
  • Chow HH, Cai Y, Alberts DS, Hakim I, Dorr R, Shahi F, Crowell JA, Yang CS, Hara Y. (2001) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol Biomarkers Prev. 10:53-58.
    [ PubMed Abstract ]
  • Clifford JL, Sabichi AL, Zou C, Yang X, Steele VE, Kelloff GJ, Lotan R, Lippman SM. (2001) Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer. Cancer Epidemiol Biomarkers Prev. 10:391-395.
    [ PubMed Abstract ]
  • Cohen LA, Zhao Z, Pittman B, Aliaga C, Lubet R. (2001) Feeding thiol-containing compounds, derived from vegetables, fails to inhibit N-methylnitrosourea-induced mammary tumorigenesis. Cancer Detect Prev. 25:254-261.
    [ PubMed Abstract ]
  • Crowell JA, Holmes CJ. (2001) Agent identification and preclinical testing. Cancer Treat Res. 106:1-30.
    [ PubMed Abstract ]
  • D'Agostini F, Balansky RM, Bennicelli C, Lubet RA, Kelloff GJ, De Flora S. (2001) Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice. Int J Oncol. 18:607-615.
    [ PubMed Abstract ]
  • D'Agostini F, Balansky RM, Izzotti A, Lubet RA, Kelloff GJ, De Flora S. (2001) Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats. Carcinogenesis. 22:375-380.
    [ PubMed Abstract ]
  • D'Ambrosio SM, Gibson-D'Ambrosio RE, Wani G, Casto B, Milo GE, Kelloff GJ, Steele VE. (2001) Modulation of Ki67, p53 and RARbeta expression in normal, premalignant and malignant human oral epithelial cells by chemopreventive agents. Anticancer Res. 21:3229-3235.
    [ PubMed Abstract ]
  • Dimitrov NV, Leece CM, Tompkins ER, Seymour E, Bennink M, Gardiner J, Crowell J, Hawk E, Nashawaty M, Bennett JL. (2001) Oltipraz concentrations in plasma, buccal mucosa cells, and lipids: pharmacological studies. Cancer Epidemiol Biomarkers Prev. 10:201-207.
    [ PubMed Abstract ]
  • Elmore E, Luc TT, Steele VE, Redpath JL. (2001) Comparative tissue-specific toxicities of 20 cancer preventive agents using cultured cells from 8 different normal human epithelia. In Vitr Mol Toxicol. 14:191-207.
    [ PubMed Abstract ]
  • Elmore E, Stringer DE, Steele VE, Gerner EW, Redpath JL. (2001) Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation. Anticancer Res. 21:1163-1165.
    [ PubMed Abstract ]
  • Fischer SM, Lee M, Lubet RA. (2001) Difluoromethylornithine is effective as both a preventive and therapeutic agent against the development of UV carcinogenesis in SKH hairless mice. Carcinogenesis. 22:83-88.
    [ PubMed Abstract ]
  • Green JE, Shibata MA, Shibata E, Moon RC, Anver MR, Kelloff G, Lubet R. (2001) 2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. Cancer Res. 61:7449-7455.
    [ PubMed Abstract ]
  • Gupta A, Nines R, Rodrigo KA, Aziz RA, Carlton PS, Gray DL, Steele VE, Morse MA, Stoner GD. (2001) Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat. J Natl Cancer Inst. 93:990-998.
    [ PubMed Abstract ]
  • Hebert JL, Khugyani F, Athar M, Kopelovich L, Epstein EH, Jr., Aszterbaum M. (2001) Chemoprevention of basal cell carcinomas in the ptc1+/- mouse--green and black tea. Skin Pharmacol Appl Skin Physiol. 14:358-362.
    [ PubMed Abstract ]
  • Herbert BS, Wright AC, Passons CM, Wright WE, Ali IU, Kopelovich L, Shay JW. (2001) Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells. J Natl Cancer Inst. 93:39-45.
    [ PubMed Abstract ]
  • Herzog CR, Crist KA, Sabourin CL, Kelloff GJ, Boone CW, Stoner GD, You M. (2001) Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas. Mol Carcinog. 30:159-168.
    [ PubMed Abstract ]
  • Hoque A, Lippman SM, Boiko IV, Atkinson EN, Sneige N, Sahin A, Weber DM, Risin S, Lagios MD, Schwarting R, Colburn WJ, Dhingra K, Follen M, Kelloff GJ, Boone CW, Hittelman WN. (2001) Quantitative nuclear morphometry by image analysis for prediction of recurrence of ductal carcinoma in situ of the breast. Cancer Epidemiol Biomarkers Prev. 10:249-259.
    [ PubMed Abstract ]
  • Izzotti A, Balansky RM, Dagostini F, Bennicelli C, Myers SR, Grubbs CJ, Lubet RA, Kelloff GJ, De Flora S. (2001) Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Cancer Res. 61:2472-2479.
    [ PubMed Abstract ]
  • Johanning GL, Cope MB, Wilborn T, Grubbs CJ, Lubet RA. (2001) Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice. Anticancer Res. 21:1691-1695.
    [ PubMed Abstract ]
  • Katdare M, Kopelovich L, Telang N. (2001) Chemopreventive agents inhibit aberrant proliferation of the aneuploid phenotype in a colon epithelial cell line established from Apc 1638N [+/-] mouse. Ann N Y Acad Sci. 952:169-174.
    [ PubMed Abstract ]
  • Kelloff GJ, Sigman CC, Hawk ET, Johnson KM, Crowell JA, Guyton KZ. (2001) Surrogate end-point biomarkers in chemopreventive drug development. IARC Sci Publ. 154:13-26.
    [ PubMed Abstract ]
  • Kelloff GJ, Lieberman R, Steele VE, Boone CW, Lubet RA, Kopelovich L, Malone WA, Crowell JA, Higley HR, Sigman CC. (2001) Agents, biomarkers, and cohorts for chemopreventive agent development in prostate cancer. Urology. 57:46-51.
    [ PubMed Abstract ]
  • Knott KK, McGinley JN, Lubet RA, Steele VE, Thompson HJ. (2001) Effect of the aromatase inhibitor vorozole on estrogen and progesterone receptor content of rat mammary carcinomas induced by 1-methyl-1-nitrosourea. Breast Cancer Res Treat. 70:171-183.
    [ PubMed Abstract ]
  • Liebes L, Conaway CC, Hochster H, Mendoza S, Hecht SS, Crowell J, Chung FL. (2001) High-performance liquid chromatography-based determination of total isothiocyanate levels in human plasma: application to studies with 2-phenethyl isothiocyanate. Anal Biochem. 291:279-289.
    [ PubMed Abstract ]
  • Lin L, Wang Y, Bergman G, Kelloff GJ, Lubet RA, You M. (2001) Detection of differentially expressed genes in mouse lung adenocarcinomas. Exp Lung Res. 27:217-229.
    [ PubMed Abstract ]
  • Mehta RG, Bhat KP, Hawthorne ME, Kopelovich L, Mehta RR, Christov K, Kelloff GJ, Steele VE, Pezzuto JM. (2001) Induction of atypical ductal hyperplasia in mouse mammary gland organ culture. J Natl Cancer Inst. 93:1103-1106.
    [ PubMed Abstract ]
  • Newmark HL, Yang K, Lipkin M, Kopelovich L, Liu Y, Fan K, Shinozaki H. (2001) A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis. 22:1871-1875.
    [ PubMed Abstract ]
  • Rodriguez-Burford C, Lubet RA, Steele VE, Eto I, Bandy M, Juliana MM, Weiss HL, Grizzle WE, Kelloff GJ, Grubbs CJ. (2001) Effects of acute and chronic body weight gain reductions in the evaluation of agents for efficacy in mammary cancer prevention. Oncol Rep. 8:373-379.
    [ PubMed Abstract ]
  • Sharma S, Ghoddoussi M, Gao P, Kelloff GJ, Steele VE, Kopelovich L. (2001) A quantitative angiogenesis model for efficacy testing of chemopreventive agents. Anticancer Res. 21:3829-3837.
    [ PubMed Abstract ]
  • Sun SY, Yue P, Kelloff GJ, Steele VE, Lippman SM, Hong WK, Lotan R. (2001) Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells. Cancer Epidemiol Biomarkers Prev. 10:595-601.
    [ PubMed Abstract ]
  • Wang Y, Hu L, Yao R, Wang M, Crist KA, Grubbs CJ, Johanning GL, Lubet RA, You M. (2001) Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor. Oncogene. 20:7710-7721.
    [ PubMed Abstract ]
  • Weiss HL, Urban DA, Grizzle WE, Cronin KA, Freedman LS, Kelloff GJ, Lieberman R. (2001) Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer. Urology. 57:220-223.
    [ PubMed Abstract ]
  • Zujewski J, Vaughn-Cooke A, Flanders KC, Eckhaus MA, Lubet RA, Wakefield LM. (2001) Transforming growth factors-beta are not good biomarkers of chemopreventive efficacy in a preclinical breast cancer model system. Breast Cancer Res. 3:66-75.
    [ PubMed Abstract ]
  • Arif JM, Gairola CG, Kelloff GJ, Lubet RA, Gupta RC. (2000) Inhibition of cigarette smoke-related DNA adducts in rat tissues by indole-3-carbinol. Mutat Res. 452(1):11-18.
    [ PubMed Abstract ]
  • Boone CW, Kelloff GJ. (2000) Endpoint markers for cancer chemoprevention trials derived from the lesion of precancer (intraepithelial neoplasia) measured by computer-assisted quantitative image analysis. J Cell Biochem Suppl. 34:67-72. Review.
    [ PubMed Abstract ]
  • Boone CW, Stoner GD, Bacus JV, Kagan V, Morse MA, Kelloff GJ, Bacus JW. (2000) Chemoprevention with theaflavins of rat esophageal intraepithelial neoplasia quantitatively monitored by image tile analysis. Cancer Epidemiol Biomarkers Prev. 9(11):1149-54.
    [ PubMed Abstract ]
  • Boone CW, Stoner GD, Bacus JV, Kagan V, Morse MA, Kelloff GJ, Bacus JW. (2000) Quantitative grading of rat esophageal carcinogenesis using computer-assisted image tile analysis. Cancer Epidemiol Biomarkers Prev. 9(5):495-500.
    [ PubMed Abstract ]
  • Cho KH, Pezzuto JM, Bolton JL, Steele VE, Kelloff GJ, Lee SK, Constantinou A. (2000) Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity. Eur J Cancer. 36(16):2146-56.
    [ PubMed Abstract ]
  • Chow HH, Earnest DL, Clark D, Mason-Liddil N, Kramer CB, Einspahr JG, Guillen-Rodriguez JM, Roe DJ, Malone W, Crowell JA, Alberts DS. (2000) Effect of subacute ibuprofen dosing on rectal mucosal prostaglandin E2 levels in healthy subjects with a history of resected polyps. Cancer Epidemiol Biomarkers Prev. 9(4):351-6.
    [ PubMed Abstract ]
  • Christov K, Shilkaitis A, Green A, Mehta RG, Grubbs C, Kelloff G, Lubet R. (2000) Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole. Breast Cancer Res Treat. 60(2):117-28.
    [ PubMed Abstract ]
  • D'Agostini F, Balansky R, Pesce C, Fiallo P, Lubet RA, Kelloff GJ, De Flora S. (2000) Induction of alopecia in mice exposed to cigarette smoke. Toxicol Lett. 114(1-3):117-23.
    [ PubMed Abstract ]
  • D'Ambrosio,S.M., D'Ambrosio,R.G., Milo,G.E., Casto,B.C., Kelloff,G.J., Steele,V.E. (2000) Differential responses of normal, premalignant, and malignant human oral epithelial cells by chemopreventive agents. AntiCancer Research 20(4): 2273-2280.
    [ PubMed Abstract ]
  • Decensi A, Torrisi R, Bruno S, Costantini M, Curotto A, Nicolo G, Malcangi B, Baglietto L, Bruttini GP, Gatteschi B, Rondanina G, Varaldo M, Perloff M, Malone WF, Bruzzi P. (2000) Randomized trial of fenretinide in superficial bladder cancer using DNA flow cytometry as an intermediate end point. Cancer Epidemiol Biomarkers Prev. Oct;9(10):1071-8.
    [ PubMed Abstract ]
  • Elmore E, Luc TT, Li HR, Buckmeier JA, Steele VE, Kelloff GJ, Redpath JL. (2000) Correlation of chemopreventive efficacy data from the human epidermal cell assay with in vivo data. Anticancer Res. 20(1A):27-32.
    [ PubMed Abstract ]
  • Elmore E, Luc TT, Steele VE, Kelloff GJ, Redpath JL. (2000) The human epithelial cell cytotoxicity assay for determining tissue specific toxicity. Methods Cell Sci 22(1):17-24.
    [ PubMed Abstract ]
  • Grubbs CJ, Lubet RA, Koki AT, Leahy KM, Masferrer JL, Steele VE, Kelloff GJ, Hill DL, Seibert K. (2000) Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats. Cancer Res. 60(20):5599-5602.
    [ PubMed Abstract ]
  • Guidi AJ, Berry DA, Broadwater G, Perloff M, Norton L, Barcos MP, Hayes DF. (2000) Association of angiogenesis in lymph node metastases with outcome of breast cancer. J Natl Cancer Inst. Mar 15;92(6):486-92.
    [ PubMed Abstract ]
  • Gunning WT, Kramer PM, Lubet RA, Steele VE, Pereira MA.(2000) Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice. Exp Lung Res. 26(8):757-72.
    [ PubMed Abstract ]
  • Halberg RB, Katzung DS, Hoff PD, Moser AR, Cole CE, Lubet RA, Donehower LA, Jacoby RF, Dove WF. (2000) Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A. 97(7):3461-6.
    [ PubMed Abstract ]
  • Jacoby RF, Seibert K, Cole CE, Kelloff G, Lubet RA. (2000) The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. Cancer Res. 60(18):5040-4.
    [ PubMed Abstract ]
  • Hansen LA, Sigman CC, Andreola F, Ross SA, Kelloff GJ, De Luca LM. (2000) Retinoids in chemoprevention and differentiation therapy. Carcinogenesis. 21(7):1271-9.
    [ PubMed Abstract ]
  • Jacoby RF, Cole CE, Tutsch K, Newton MA, Kelloff G, Hawk ET, Lubet RA. (2000) Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. Cancer Res. 60(7):1864-70.
    [ PubMed Abstract ]
  • Kelloff GJ. (2000) Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res 78:199-334.
    [ PubMed Abstract ]
  • Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone CW, Kopelovich L, Hawk ET, Lieberman R, Lawrence JA, Ali I, Viner JL, Sigman CC. (2000) Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr. 130(2S Suppl):467S-471S. Review.
    [ PubMed Abstract ]
  • Kelloff GJ, Sigman CC, Johnson KM, Boone CW, Greenwald P, Crowell JA, Hawk ET, Doody LA. (2000) Perspectives on surrogate end points in the development of drugs that reduce the risk of cancer. Cancer Epidemiol Biomarkers Prev. 9(2):127-37. Review.
    [ PubMed Abstract ]
  • Lantry LE, Zhang Z, Yao R, Crist KA, Wang Y, Ohkanda J, Hamilton AD, Sebti SM, Lubet RA, You M (2000) Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 21(1):113-6.
    [ PubMed Abstract ]
  • Lawrence JA, Malpas PB, Sigman CC, Kelloff GJ. (2000) Clinical development of estrogen modulators for breast cancer chemoprevention in premenopausal vs. postmenopausal women. J Cell Biochem Suppl. 34:103-14. Review.
    [ PubMed Abstract ]
  • Liu J, Gu P, Bergman G, Kelloff GJ, Boone CW, You M, Wang Y. (2000) Detection of genetic alterations in mouse lung adenocarcinomas by two-dimensional gel electrophoresis. Exp Lung Res. 26(8):651-8.
    [ PubMed Abstract ]
  • Liu Y, Kyle E, Lieberman R, Crowell J, Kelloff G, Bergan RC. (2000) Focal adhesion kinase (FAK) phosphorylation is not required for genistein-induced FAK-beta-1- integrin complex formation. Clin Exp Metastasis.18(3):203-12.
    [ PubMed Abstract ]
  • Lantry LE, Zhang Z, Crist KA, Wang Y, Hara M, Zeeck A, Lubet RA, You M. (2000) Chemopreventive efficacy of promising farnesyltransferase inhibitors. Exp Lung Res. 26(8):773-90.
    [ PubMed Abstract ]
  • Lubet RA, Zhang Z, Wiseman RW, You M. (2000) Use of p53 transgenic mice in the development of cancer models for multiple purposes. Exp Lung Res. 26(8):581-93. Review.
    [ PubMed Abstract ]
  • Reddy BS, Hirose Y, Lubet R, Steele V, Kelloff G, Paulson S, Seibert K, Rao CV. (2000) Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. Cancer Res. 60(2):293-7.
    [ PubMed Abstract ]
  • Reddy BS, Hirose Y, Lubet RA, Steele VE, Kelloff GJ, Rao CV. (2000) Lack of chemopreventive efficacy of DL-selenomethionine in colon carcinogenesis. Int J Mol Med. 5(4):327-30.
    [ PubMed Abstract ]
  • Shilkaitis A, Green A, Steele V, Lubet R, Kelloff G, Christov, K. (2000) Neoplastic transformation of mammary epithelial cells in rats is associated with decreased apoptotic cell death. Carcinogenesis 21(2):227-233.
    [ PubMed Abstract ]
  • Shilkaitis, A., Graves, J., Mehta, R., Hu, L., You, M., Lubet, R., Steele, V., Kelloff, G., Christov, K. (2000) Bcl-2 and Bax are differentially expressed in hyperplastic, premalignant, and malignant lesions of mammary carcinogenesis. Cell Growth & Differentiation 11:437-445.
    [ PubMed Abstract ]
  • Singletary E, Lieberman R, Atkinson N, Sneige N, Sahin A, Tolley S, Colchin M, Bevers T, Stelling C, Fornage B, Fritsche H, Hittelman W, Kelloff G, Lippman SM. (2000) Novel translational model for breast cancer chemoprevention study: accrual to a presurgical intervention with tamoxifen and N-[4-hydroxyphenyl] retinamide. Cancer Epidemiol Biomarkers Prev. 9(10):1087-90.
    [ PubMed Abstract ]
  • Steele, V.E., Holmes, C.A., Hawk, E.T., Kopelovich, L., Lubet, R.A., Crowell, J.A., Sigman, C.C., and Kelloff, G.J. (2000) Potential use of lipoxygenase inhibitors for cancer chemopreventions. Exp. Opin. Invest. Drugs 9(9):2121-2138.
  • Steele VE, Kelloff GJ, Balentine D, Boone CW, Mehta R, Bagheri D, Sigman CC, Zhu S, Sharma S. (2000) Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitro bioassays. Carcinogenesis 21(1):63-67.
    [ PubMed Abstract ]
  • van Stolk R, Stoner G, Hayton WL, Chan K, DeYoung B, Kresty L, Kemmenoe BH, Elson P, Rybicki L, Church J, Provencher K, McLain D, Hawk E, Fryer B, Kelloff G, Ganapathi R, Budd GT (2000) Phase I trial of exisulind (sulindac sulfone, FGN-1) as a chemopreventive agent in patients with familial adenomatous polyposis. Clin. Cancer Res. 6(1):78-89.
    [ PubMed Abstract ]
  • Wargovich MJ, Jimenez A, McKee K, Steele VE, Velasco M, Woods J, Price R, Gray K, Kelloff GJ. (2000) Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 21(6):1149-55.
    [ PubMed Abstract ]
  • Wattenberg LW, Wiedmann TS, Estensen RD, Zimmerman CL, Galbraith AR, Steele VE, Kelloff GJ. (2000) Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. Carcinogenesis 21(2):179-182.
    [ PubMed Abstract ]
  • Yang K, Lamprecht SA, Liu Y, Shinozaki H, Fan K, Leung D, Newmark H, Steele VE, Kelloff GJ, Lipkin M. (2000) Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon. Carcinogenesis 21(9):1655-60.
    [ PubMed Abstract ]
  • Zhang Z, Liu Q, Lantry LE, Wang Y, Kelloff GJ, Anderson MW, Wiseman RW, Lubet RA, You M. (2000) A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. Cancer Res. 60(4):901-7.
    [ PubMed Abstract ]

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