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Chemopreventive Agent Development Research Group

Publications

View All  |  2014-2010  |  2009-2000  |  1999-1990  |  1989-1985

  • Pepper JW, Dunn BK, Fagerstrom RM, Gohagan JK, Vydelingum NA. Using systems biology to understand cancer as an evolutionary process.Exit Disclaimer Journal of Evolutionary Medicine. 2014 (2)1-8.
  • Ravillah D, Mohammed A, Qian L, Brewer M, Zhang Y, Biddick L, Steele VE, Rao CV. Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis. J Pharmacol Exp Ther. 2014 Jan;348(1):59-68. Epub 2013 Nov 11.
    [ PubMed Abstract ]
  • Armstrong WB, Taylor TH, Kennedy AR, Melrose RJ, Messadi DV, Gu M, Le AD, Perloff M, Civantos F, Goodwin WJ, Wirth LJ, Kerr AR, Meyskens FL, Jr. Bowman Birk Inhibitor Concentrate and oral leukoplakia: A randomized phase IIb trial. Cancer Prev Res (Phila) 6:410-18, 2013.
    [ PubMed Abstract ]
  • Banerjee AA, Shen H, Hautman M, Anwer J, Hong S, Kapetanovic IM, Lyubimov AV, Liu Y. Polymeric nanoparticles enhance the bioavailability of the chemopreventive agent SR13668 in beagle dogs. Curr Pharm Biotechnol Apr 11: Epub ahead of print, 2013.
    [ PubMed Abstract ]
  • Berg AK, Mandrekar SJ, Ziegler KL, Carlson EC, Szabo E, Ames MM, Boring D, Limburg PJ, Reid JM. Population pharmacokinetic model for cancer chemoprevention with sulindac in healthy subjects. J Clin Pharmacol 53:403-12, 2013.
    [ PubMed Abstract ]
  • Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, Giri D, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ. Caloric restriction reverses obesity-induced mammary gland inflammation in mice. Cancer Prev Res (Phila) 6:282-89, 2013.
    [ PubMed Abstract ]
  • Chaudhary SC, Singh T, Kapur P, Weng Z, Arumugam A, Elmets CA, Kopelovich L, Athar M. Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis. Toxicol Appl Pharmacol 268:49-255, 2013.
    [ PubMed Abstract ]
  • Dragnev K, You M, Wang Y, Lubet R. Lung cancer chemoprevention: Difficulties, promise and potential agents? Expert Opin Investig Drugs 22:35-47, 2013.
    [ PubMed Abstract ]
  • Dunn BK, Cazzaniga M, DeCensi A. Exemestane: One part of the chemopreventive spectrum for ER-positive breast cancer. Breast 22:225-37, 2013.
    [ PubMed Abstract ]
  • Fagan RL, Cryderman DE, Kopelovich L, Wallrath LL, Brenner C. Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. J Biol Chem Jul 9: Epub ahead of print, 2013.
    [ PubMed Abstract ]
  • Fan M, Pfeffer SR, Lynch HT, Cassidy P, Leachman S, Pfeffer LM, Kopelovich L. Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: Relevance to early intervention. Oncotarget 4: 128-41, 2013.
    [ PubMed Abstract ]
  • Izzotti A, Balansky R, D'Agostini F, Longobardi M, Cartiglia C, La Maestra S, Micale RT, Camoirano A, Ganchev G, Iltcheva M, Steele VE, De Flora S. Relationships between pulmonary micro-RNA and proteome profiles, systemic cytogenetic damage and lung tumors in cigarette smoke-exposed mice treated with chemopreventive agents. Carcinogenesis. 2013 Oct;34(10):2322-9. Epub 2013 May 24.
    [ PubMed Abstract ]
  • Janakiram NB, Mohammed A, Zhang Y, Brewer M, Bryant T, Lightfoot S, Steele VE, Rao CV. Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats. Cancer Prev Res (Phila). 2013 Dec;6(12):1251-61. Epub 2013 Sep 30.
    [ PubMed Abstract ]
  • Kabirov KK, Kapetanovic IM, Benbrook DM, Dinger N, Mankovskaya I, Zakharov A, Detrisac C, Pereira M, Martin-Jimenez T, Onua E, Banerjee A, van Breemen RB, Nikolic D, Chen L, Lyubimov AV. Oral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs. Drug Chem Toxicol 36:284-95, 2013.
    [ PubMed Abstract ]
  • Kaylani SZ, Xu J, Srivastava RK, Kopelovich L, Pressey JG, Athar M. Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model. Biochem Biophys Res Commun 435:557-61, 2013.
    [ PubMed Abstract ]
  • Kurundkar D, Srivastava RK, Chaudhary SC, Ballestas ME, Kopelovich L, Elmets CA, Athar M. Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicol Appl Pharmacol 266:233-44, 2013.
    [ PubMed Abstract ]
  • La Maestra S, Micale RT, De Flora S, D'Agostini F, Ganchev G, Iltcheva M, Petkov N, Steele VE, Balansky R. DNA damage in exfoliated cells and histopathological alterations in the urinary tract of mice exposed to cigarette smoke and treated with chemopreventive agents. Carcinogenesis. 2013 Jan;34(1):183-9. Epub 2012 Oct 5.
    [ PubMed Abstract ]
  • Li J, Zhu F, Lubet RA, De Luca A, Grubbs C, Ericson ME, D'Alessio A, Normanno N, Dong Z, Bode AM. Quercetin-3-methyl ether inhibits lapatinib-sensitive and -resistant breast cancer cell growth by inducing G2/M arrest and apoptosis. Mol Carcinog 52:134-43, 2013.
    [ PubMed Abstract ]
  • Lubet RA, Szabo E, Iwata KK, Gill SC, Tucker C, Bode A, Steele VE, Juliana MM, Nicastro HL, Grubbs CJ. Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis. Cancer Prev Res (Phila). 2013 May;6(5):448-54. Epub 2013 Mar 26.
    [ PubMed Abstract ]
  • Mehta RG, Peng X, Roy S, Hawthorne M, Kalra A, Alimirah F, Mehta RR, Kopelovich L. PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: Potential translational significance. Mol Cell Biochem 372:249-56, 2013.
    [ PubMed Abstract ]
  • Micale RT, La Maestra S, Di Pietro A, Visalli G, Baluce B, Balansky R, Steele VE, De Flora S. Oxidative stress in the lung of mice exposed to cigarette smoke either early in life or in adulthood. Arch Toxicol. 2013 May;87(5):915-8. Epub 2013 Feb 20. Erratum in: Arch Toxicol. 2013 May;87(5):919. Maestra, Sebastiano La [corrected to La Maestra, Sebastiano]; Pietro, Angela Di.
    [ PubMed Abstract ]
  • Mikulec CD, Rundhaug JE, Simper MS, Lubet RA, Fischer SM. The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: The relationship of short-term biomarkers to long-term skin tumor outcome. Cancer Prev Res (Phila) 6:675-85, 2013.
    [ PubMed Abstract ]
  • Mohammed A, Janakiram NB, Brewer M, Vedala K, Steele VE, Rao CV. Multitargeted low-dose GLAD combination chemoprevention: a novel and promising approach to combat colon carcinogenesis. Neoplasia. 2013 May;15(5):481-90.
    [ PubMed Abstract ]
  • Nicastro HL, Dunn BK. Selenium and prostate cancer prevention: Insights from the selenium and vitamin E cancer prevention trial (SELECT). Nutrients 5:1122-48, 2013.
    [ PubMed Abstract ]
  • Nicastro HL, Grubbs CJ, Juliana MM, Bode AM, Kim MS, Lu Y, You M, Milne G, Boring D, Steele VE, Lubet RA. Preventive effects of NSAIDs, NO-NSAIDs, and NSAIDs plus difluoromethylornithine in a chemically induced urinary bladder cancer model. Cancer Prev Res (Phila). 2013 Dec 17. [Epub ahead of print]
    [ PubMed Abstract ]
  • Pepper JA, Vydelingum NA, Dunn BK, Fagerstrom RM. Agent-based models in cancer prevention. In: Kora AB, editor. Advances in Computational Modeling Research: Theory, Developments and Applications. Hauppauge, NY: Nova Science Publishers, 2013, p.105-16.
  • Perloff M, Steele VE. Early-phase development of cancer prevention agents: challenges and opportunities. Cancer Prev Res (Phila). 2013 May;6(5):379-83. Epub 2013 Mar 6.
    [ PubMed Abstract ]
  • Rao CV, Patlolla JM, Cooma I, Kawamori T, Steele VE. Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ?-3 fatty acid rich perilla oil. Nutr Cancer. 2013;65 Suppl 1:54-60.
    [ PubMed Abstract ]
  • Vedell PT, Lu Y, Grubbs CJ, Yin Y, Jiang H, Bland KI, Muccio DD, Cvetkovic D, You M, Lubet R. Effects on gene expression in rat liver after administration of RXR agonists: UAB30, 4 methyl-UAB30, and Targretin (bexarotene). Mol Pharmacol 83:698-708, 2013.
    [ PubMed Abstract ]
  • Wang Y, Yao R, Gao S, Wen W, Du Y, Szabo E, Hu M, Lubet RA, You M. Chemopreventive effect of a mixture of Chinese herbs (antitumor B) on chemically induced oral carcinogenesis. Mol Carcinog 52:49-56, 2013.
    [ PubMed Abstract ]
  • Witherspoon M, Chen Q, Kopelovich L, Gross SS, Lipkin SM. Unbiased metabolite profiling indicates that a diminished thymidine pools is the underlying mechanism of colon cancer chemoprevention by a-difluoromethylornithine (DFMO). Cancer Discov Jun 14: Epub ahead of print, 2013.
    [ PubMed Abstract ]
  • Xie H, Lee MH, Zhu F, Reddy K, Huang Z, Kim DJ, Li Y, Peng C, Lim do Y, Kang S, Jung SK, Li X, Li H, Ma W, Lubet RA, Ding J, Bode AM, Dong Z. Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo. Mol Cancer Ther 12:950-58, 2013.
    [ PubMed Abstract ]
  • Xie H, Lee MH, Zhu F, Reddy K, Peng C, Li Y, Lim do Y, Kim DJ, Li X, Kang S, Li H, Ma W, Lubet RA, Ding J, Bode AM, Dong Z. Identification of an Aurora kinase inhibitor specific for the Aurora B isoform. Cancer Res 73:716-24, 2013.
    [ PubMed Abstract ]
  • Yuan H, Lu J, Xiao J, Upadhyay G, Umans R, Kallakury B, Yin Y, Fant ME, Kopelovich L, Glazer RI. PPARd induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. Cancer Res Jun 27: Epub ahead of print, 2013.
    [ PubMed Abstract ]
  • Balansky R, D'Agostini F, Micale RT, La Maestra S, Steele VE, De Flora S. Dose-related cytogenetic damage in pulmonary alveolar macrophages from mice exposed to cigarette smoke early in life. Arch Toxicol 86:509-16, 2012.
    [ PubMed Abstract ]
  • Balansky R, Ganchev G, Iltcheva M, Kratchanova M, Denev P, Kratchanov C, Polasa K, D'Agostini F, Steele VE, De Flora S. Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke. Int J Cancer 131:1991-97, 2012.
    [ PubMed Abstract ]
  • Balansky R, Ganchev G, Iltcheva M, Nikolov M, Steele VE, De Flora S. Differential carcinogenicity of cigarette smoke in mice exposed either transplacentally, early in life or in adulthood. Int J Cancer 130:1001-10, 2012.
    [ PubMed Abstract ]
  • Balansky R, Ganchev G, Iltcheva M, Steele VE, De Flora S. Transplacental antioxidants inhibit lung tumors in mice exposed to cigarette smoke after birth: A novel preventative strategy? Curr Cancer Drug Targets 12:164-69, 2012.
    [ PubMed Abstract ]
  • Chattopadhyay M, Kodela R, Nath N, Barsegian A, Boring D, Kashfi K. Hydrogen sulfide-releasing aspirin suppresses NF-κB signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. Biochem Pharmacol 83:723-32, 2012.
    [ PubMed Abstract ]
  • Chattopadhyay M, Kodela R, Nath N, Dastagirzada YM, Velazquez-Martinez CA, Boring D, Kashfi K. Hydrogen sulfide-releasing NSAIDs inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect. Biochem Pharmacol 83:715-22, 2012.
    [ PubMed Abstract ]
  • Chattopadhyay M, Kodela R, Nath N, Street CR, Velazquez-Martinez CA, Boring D, Kashfi K. Hydrogen sulfide-releasing aspirin modulates xenobiotic metabolizing enzymes in vitro and in vivo. Biochem Pharmacol 83:733-40, 2012.
    [ PubMed Abstract ]
  • Chaudhary SC, Kurundkar D, Elmets CA, Kopelovich L, Athar M. Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway. Photochem Photobiol 88:1149-56, 2012.
    [ PubMed Abstract ]
  • Chen H, Yao K, Nadas J, Bode AM, Malakhova M, Oi N, Li H, Lubet RA, Dong Z. Prediction of molecular targets of cancer preventing flavonoid compounds using computational methods. PLoS One 7: e38261, 2012.
    [ PubMed Abstract ]
  • Crous-Bou M, Rennert G, Salazar R, Rodriguez-Moranta F, Rennert HS, Lejbkowicz F, Kopelovich L, Lipkin SM, Gruber SB, Moreno V. Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer. Mutagenesis 27:169-76, 2012.
    [ PubMed Abstract ]
  • De Flora S, Balansky R, D'Agostini F, Cartiglia C, Longobardi M, Steele VE, Izzotti A. Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents. Int J Cancer 131:2763-73, 2012.
    [ PubMed Abstract ]
  • Decensi A, Dunn BK, Puntoni M, Gennari A, Ford LG. Exemestane for breast cancer prevention: A critical shift? Cancer Discov 2:25-40, 2012.
    [ PubMed Abstract ]
  • Doppalapudi RS, Riccio ES, Davis Z, Menda S, Wang A, Du N, Green C, Kopelovich L, Rao CV, Benbrook DM, Kapetanovic IM. Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen. Mutat Res 746:78-88, 2012.
    [ PubMed Abstract ]
  • Dunn BK, Akpa E. Biomarkers as surrogate endpoints in cancer trials. Semin Oncol Nurs 28:99-108, 2012.
    [ PubMed Abstract ]
  • Izzotti A, Cartiglia C, Steele VE, De Flora S. MicroRNAs as targets for dietary and pharmaco-logical inhibitors of mutagenesis and carcinogenesis. Mutat Res 751:287-303, 2012.
    [ PubMed Abstract ]
  • Janakiram NB, Mohammed A, Qian L, Choi CI, Steele VE, Rao CV. Chemopreventive effects of RXR-selective rexinoid bexarotene on intestinal neoplasia of ApcMin/+ mice. Neoplasia 14:159-68, 2012.
    [ PubMed Abstract ]
  • Kapetanovic IM. Comment on 'Resveratrol in human cancer chemoprevention--choosing the 'right' dose'. Mol Nutr Food Res 56:523, 2012.
    [ PubMed Abstract ]
  • Kapetanovic IM, Lyubimov AV, Kabirova EV, Kabirov KK, Rasay L, Swezey R, Green C, Kopelovich L. Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chem Biol Interact 197:16-22, 2012.
    [ PubMed Abstract ]
  • Kapetanovic IM, Muzzio M, McCormick DL, Thompson TN, Johnson WD, Horn TL, Mohammed A, Rao CV, Kopelovich L. Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats. Cancer Chemother Pharmacol 69:1301-06, 2012.
    [ PubMed Abstract ]
  • Lazzeroni M, Serrano D, Dunn BK, Heckman-Stoddard BM, Lee O, Khan S, Decensi A. Oral low dose and topical tamoxifen for breast cancer prevention: Modern approaches for an old drug. Breast Cancer Res 14:214, 2012.
    [ PubMed Abstract ]
  • Li X, Li H, Li S, Zhu F, Kim DJ, Xie H, Li Y, Nadas J, Oi N, Zykova TA, Yu DH, Lee MH, Kim MO, Wang L, Ma W, Lubet RA, Bode AM, Dong Z, Dong Z. Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B. Carcinogenesis 33:2548-57, 2012.
    [ PubMed Abstract ]
  • Lu Y, Liu P, Van den Bergh F, Zellmer V, James M, Wen W, Grubbs CJ, Lubet RA, You M. Modulation of gene expression and cell-cycle signaling pathways by the EGFR inhibitor gefitinib (Iressa) in rat urinary bladder cancer. Cancer Prev Res (Phila) 5:248-59, 2012.
    [ PubMed Abstract ]
  • Lubet RA, Clapper ML, McCormick DL, Pereira MA, Chang WC, Steele VE, Fischer SM, Juliana MM, Grubbs CJ. Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck and mammary cancers. Oncol Rep 27:1400-06, 2012.
    [ PubMed Abstract ]
  • Mohammed A, Qian L, Janakiram NB, Lightfoot S, Steele VE, Rao CV. Atorvastatin delays progression of pancreatic lesions to carcinoma by regulating PI3/AKT signaling in p48Cre/+ LSL-KrasG12D/+ mice. Int J Cancer 131:1951-62, 2012.
    [ PubMed Abstract ]
  • Montrose DC, Zhou XK, Kopelovich L, Yantiss RK, Karoly ED, Subbaramaiah K, Dannenberg AJ. Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer Prev Res (Phila) 5:1358-67, 2012.
    [ PubMed Abstract ]
  • Muzzio M, Huang Z, Hu SC, Johnson WD, McCormick DL, Kapetanovic IM. Determination of resveratrol and its sulfate and glucuronide metabolites in plasma by LC-MS/MS and their pharmacokinetics in dogs. J Pharm Biomed Anal 59:201-08, 2012.
    [ PubMed Abstract ]
  • Oi N, Chen H, Ok Kim M, Lubet RA, Bode AM, Dong Z. Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K. Cancer Prev Res (Phila) 5:1103-14, 2012.
    [ PubMed Abstract ]
  • Patlolla JM, Zhang Y, Li Q, Steele VE, Rao CV. Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats. Int J Oncol 40:170-75, 2012.
    [ PubMed Abstract ]
  • Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BC. Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin. Int J Cancer 131:1277-86, 2012.
    [ PubMed Abstract ]
  • Rao CV, Mohammed A, Janakiram NB, Li Q, Ritchie RL, Lightfoot S, Vibhudutta A, Steele VE. Inhibition of pancreatic intraepithelial neoplasia progression to carcinoma by nitric oxide-releasing aspirin in p48Cre/+-LSL-KrasG12D/+ mice. Neoplasia 14:778-87, 2012.
    [ PubMed Abstract ]
  • Roberts NJ, Jiao Y, Yu J, Kopelovich L, Petersen GM, Bondy ML, Gallinger S, Schwartz AG, Syngal S, Cote ML, Axilbund J, Schulick R, Ali SZ, Eshleman JR, Velculescu VE, Goggins M, Vogelstein B, Papadopoulos N, Hruban RH, Kinzler KW, Klein AP. ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov 2:41-46, 2012.
    [ PubMed Abstract ]
  • Roman-Perez E, Casbas-Hernandez P, Pirone JR, Rein J, Carey LA, Lubet RA, Mani SA, Amos KD, Troester MA. Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients. Breast Cancer Res 14:R51, 2012.
    [ PubMed Abstract ]
  • Shen H, Banerjee AA, Mlynarska P, Hautman M, Hong S, Kapetanovic IM, Lyubimov AV, Liu Y. Enhanced oral bioavailability of a cancer preventive agent (SR13668) by employing polymeric nanoparticles with high drug loading. J Pharm Sci 101:3877-85, 2012.
    [ PubMed Abstract ]
  • Singh T, Chaudhary SC, Kapur P, Weng Z, Elmets CA, Kopelovich L, Athar M. Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesis. Photochem Photobiol 88:1141-48, 2012.
    [ PubMed Abstract ]
  • Smith JJ, Dunn BK. Biomarkers as molecular targets of drug interventions. Semin Oncol Nurs 28:109-15, 2012.
    [ PubMed Abstract ]
  • Smith JJ, Dunn BK. Introduction. Semin Oncol Nurs 28:85-86, 2012.
    [ PubMed Abstract ]
  • Subbaramaiah K, Howe LR, Zhou XK, Yang P, Hudis CA, Kopelovich L, Dannenberg AJ. Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: Evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1. Cancer Prev Res (Phila) 5:1183-94, 2012.
    [ PubMed Abstract ]
  • Subbaramaiah K, Morris PG, Zhou XK, Morrow M, Du B, Giri D, Kopelovich L, Hudis CA, Dannenberg AJ. Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov 2:356-65, 2012.
    [ PubMed Abstract ]
  • Umar A, Dunn BK, Greenwald P. Future directions in cancer prevention. Nat Rev Cancer 12:835-48, 2012.
    [ PubMed Abstract ]
  • Wang Y, Rouggly L, You M, Lubet R. Animal models of lung cancer characterization and use for chemoprevention research. Prog Mol Biol Transl Sci 105:211-26, 2012.
    [ PubMed Abstract ]
  • Xie G, Nie T, Mackenzie GG, Sun Y, Huang L, Ouyang N, Alston N, Zhu C, Murray OT, Constantinides PP, Kopelovich L, Rigas B. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. Br J Pharmacol 165:2152-66, 2012.
    [ PubMed Abstract ]
  • Xie H, Zhu F, Huang Z, Lee MH, Kim DJ, Li X, Lim do Y, Jung SK, Kang S, Li H, Reddy K, Wang L, Ma W, Lubet RA, Bode AM, Dong Z. Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo. Carcinogenesis 33:1814-21, 2012.
    [ PubMed Abstract ]
  • Yuan H, Kopelovich L, Yin Y, Lu J, Glazer RI. Drug-targeted inhibition of peroxisome proliferator-activated receptor-gamma enhances the chemopreventive effect of anti-estrogen therapy. Oncotarget 3:345-56, 2012.
    [ PubMed Abstract ]
  • Yuan H, Upadhyay G, Lu J, Kopelovich L, Glazer RI. The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature. Cancer Prev Res (Phila) 5:754-64, 2012.
    [ PubMed Abstract ]
  • Yuan H, Upadhyay G, Yin Y, Kopelovich L, Glazer RI. Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation. Cancer Prev Res (Phila) 5:51-60, 2012.
    [ PubMed Abstract ]
  • Zhang Q, Pan J, North PE, Yang S, Lubet RA, Wang Y, You M. Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity. Cancer Prev Res (Phila) 5:717-25, 2012.
    [ PubMed Abstract ]
  • Zhang Q, Pan J, Wang Y, Lubet R, You M. Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis. Mol Carcinog 2012;52:686-91.
    [ PubMed Abstract ]
  • Athar M, Elmets CA, Kopelovich L. Pharmacological activation of p53 in cancer cells. Curr Pharm Des 17:631-39, 2011.
    [ PubMed Abstract ]
  • Athar M, Kopelovich L. Rapamycin and mTORC1 inhibition in the mouse: Skin cancer prevention. Cancer Prev Res (Phila) 4:957-61, 2011.
    [ PubMed Abstract ]
  • Athar M, Walsh SB, Kopelovich L, Elmets CA. Pathogenesis of nonmelanoma skin cancers in organ transplant recipients. Arch Biochem Biophys 508:159-63, 2011.
    [ PubMed Abstract ]
  • Bishayee A, Ahmed S, Brankov N, Perloff M. Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. Front Biosci 16:980-96, 2011.
    [ PubMed Abstract ]
  • Dunn BK, Jegalian K, Greenwald P. Biomarkers for early detection and as surrogate endpoints in cancer prevention trials: Issues and opportunities. Recent Results Cancer Res 188:21-47, 2011.
    [ PubMed Abstract ]
  • Fischer SM, Hawk ET, Lubet RA. Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention. Cancer Prev Res (Phila) 4:1728-35, 2011.
    [ PubMed Abstract ]
  • Fu H, Zhang J, Pan J, Zhang Q, Lu Y, Wen W, Lubet RA, Szabo E, Chen R, Wang Y, Chen DR, You M. Chemoprevention of lung carcinogenesis by the combination of aerosolized budesonide and oral pioglitazone in A/J mice. Mol Carcinog 50:913-21, 2011.
    [ PubMed Abstract ]
  • Green CE, Swezey R, Bakke J, Shinn W, Furimsky A, Bejugam N, Shankar GN, Jong L, Kapetanovic IM. Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent. Cancer Chemother Pharmacol 67:995-1006, 2011.
    [ PubMed Abstract ]
  • Izzotti A, Larghero P, Balansky R, Pfeffer U, Steele VE, De Flora S. Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung. Mutat Res 717:17-24, 2011.
    [ PubMed Abstract ]
  • Izzotti A, Larghero P, Longobardi M, Cartiglia C, Camoirano A, Steele VE, De Flora S. Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung. Mutat Res 717:9-16, 2011.
    [ PubMed Abstract ]
  • Johnson WD, Morrissey RL, Usborne AL, Kapetanovic I, Crowell JA, Muzzio M, McCormick DL. Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity. Food Chem Toxicol 49:3319-27, 2011.
    [ PubMed Abstract ]
  • Johnson WD, Muzzio M, Detrisac CJ, Kapetanovic IM, Kopelovich L, McCormick DL. Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs. Toxicology 289:141-50, 2011.
    [ PubMed Abstract ]
  • Kapetanovic IM, Muzzio M, Huang Z, Thompson TN, McCormick DL. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats. Cancer Chemother Pharmacol 68:593-601, 2011.
    [ PubMed Abstract ]
  • Kim DJ, Reddy K, Kim MO, Li Y, Nadas J, Cho YY, Kim JE, Shim JH, Song NR, Carper A, Lubet RA, Bode AM, Dong Z. (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. Cancer Prev Res (Phila) 4:1842-51, 2011.
    [ PubMed Abstract ]
  • Kim KH, Back JH, Zhu Y, Arbesman J, Athar M, Kopelovich L, Kim AL, Bickers DR. Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progression. J Invest Dermatol 131:195-202, 2011.
    [ PubMed Abstract ]
  • Kodela R, Chattopadhyay M, Nath N, Cieciura LZ, Pospishill L, Boring D, Crowell JA, Kashfi K. Synthesis and biological activity of acetyl-protected hydroxybenzyl diethyl phosphates (EHBP) as potential chemotherapeutic agents. Bioorg Med Chem Lett 21:7146-50, 2011.
    [ PubMed Abstract ]
  • La Maestra S, Kisby GE, Micale RT, Johnson J, Kow YW, Bao G, Sheppard C, Stanfield S, Tran H, Woltjer RL, D'Agostini F, Steele VE, De Flora S. Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice. Toxicol Sci 123:471-79, 2011.
    [ PubMed Abstract ]
  • Li J, Cho YY, Langfald A, Carper A, Lubet RA, Grubbs CJ, Ericson ME, Bode AM. Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways. Cancer Prev Res (Phila) 4:1190-97, 2011.
    [ PubMed Abstract ]
  • Li Y, Kim DJ, Ma W, Lubet RA, Bode AM, Dong Z. Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. J Chem Inf Model 51:2904-14, 2011.
    [ PubMed Abstract ]
  • Lindeblad M, Kapetanovic IM, Kabirov KK, Dinger N, Mankovskaya I, Morrisey R, Martin-Jimenez T, Lyubimov A. Assessment of oral toxicity and safety of 9-cis-UAB30, a potential chemopreventive agent, in rat and dog studies. Drug Chem Toxicol 34:300-10, 2011.
    [ PubMed Abstract ]
  • Lubet RA, Heckman BM, De Flora SL, Steele VE, Crowell JA, Juliana MM, Grubbs CJ. Effects of 5,6-benzoflavone, indole-3-carbinol (I3C) and diindolylmethane (DIM) on chemically-induced mammary carcinogenesis: Is DIM a substitute for I3C? Oncol Rep 26:731-36, 2011.
    [ PubMed Abstract ]
  • Lubet RA, Lu Y, Bode AM, You M, Verney ZM, Steele VE, Townsend R, Juliana MM, Grubbs CJ. Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: Dose dependency and modulation of biomarkers. Oncol Rep 25:1389-97, 2011.
    [ PubMed Abstract ]
  • Mackenzie GG, Ouyang N, Xie G, Vrankova K, Huang L, Sun Y, Komninou D, Kopelovich L, Rigas B. Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. Cancer Prev Res (Phila) 4:1052-60, 2011.
    [ PubMed Abstract ]
  • Marshall JR, Ip C, Romano K, Fetterly G, Fakih M, Jovanovic B, Perloff M, Crowell J, Davis W, French-Christy R, Dew A, Coomes M, Bergan R. Methyl selenocysteine: Single-dose pharmacokinetics in men. Cancer Prev Res (Phila) 4:1938-44, 2011.
    [ PubMed Abstract ]
  • McIlhatton MA, Tyler J, Kerepesi LA, Bocker-Edmonston T, Kucherlapati MH, Edelmann W, Kucherlapati R, Kopelovich L, Fishel R. Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. Cancer Prev Res (Phila) 4:684-93, 2011.
    [ PubMed Abstract ]
  • Mohammed A, Janakiram NB, Li Q, Choi CI, Zhang Y, Steele VE, Rao CV. Chemoprevention of colon and small intestinal tumorigenesis in APCMin/+ mice by licofelone, a novel dual 5 LOX/COX inhibitor: Potential implications for human colon cancer prevention. Cancer Prev Res (Phila) 4:2015-26, 2011.
    [ PubMed Abstract ]
  • Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, Subbaramaiah K, Dannenberg AJ. Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res (Phila) 4:1021-29, 2011.
    [ PubMed Abstract ]
  • Muzzio M, Huang Z, Johnson WD, McCormick DL, Kapetanovic IM. Determination and stability of CP-31398 in plasma from experimental animals by LC-MS/MS. J Pharm Biomed Anal 56:809-14, 2011.
    [ PubMed Abstract ]
  • Nyante SJ, Black A, Kreimer AR, Duggan MA, Carreon JD, Kessel B, Buys SS, Ragard LR, Johnson KA, Dunn BK, Lamerato L, Commins JM, Berg CD, Sherman ME. Pathologic findings following false-positive screening tests for ovarian cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial. Gynecol Oncol 120:474-79, 2011.
    [ PubMed Abstract ]
  • Parman T, Bunin DI, Ng HH, McDunn JE, Wulff JE, Wang A, Swezey R, Rasay L, Fairchild DG, Kapetanovic IM, Green CE. Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity. Toxicol Sci 124:487-501, 2011.
    [ PubMed Abstract ]
  • Patel BB, Li XM, Dixon MP, Blagoi EL, Nicolas E, Seeholzer SH, Cheng D, He YA, Coudry RA, Howard SD, Riddle DM, Cooper HC, Boman BM, Conrad P, Crowell JA, Bellacosa A, Knudson A, Yeung AT, Kopelovich L. APC+/- alters colonic fibroblast proteome in FAP. Oncotarget 2:197-208, 2011.
    [ PubMed Abstract ]
  • Pollock CB, Yin Y, Yuan H, Zeng X, King S, Li X, Kopelovich L, Albanese C, Glazer RI. PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis. PLoS One 6:e16215, 2011.
    [ PubMed Abstract ]
  • Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR. Altered folate availability modifies the molecular environment of the human colorectum: Implications for colorectal carcinogenesis. Cancer Prev Res (Phila) 4:530-43, 2011.
    [ PubMed Abstract ]
  • Reid JM, Walden CA, Qin R, Ziegler KL, Haslam JL, Rajewski RA, Warndahl R, Fitting CL, Boring D, Szabo E, Crowell J, Perloff M, Jong L, Bauer BA, Mandrekar SJ, Ames MM, Limburg PJ. Phase 0 clinical chemoprevention trial of the Akt inhibitor SR13668. Cancer Prev Res (Phila) 4:347-53, 2011.
    [ PubMed Abstract ]
  • Scaglioni PP, Cai LF, Majid SM, Yung TM, Socci ND, Kogan SC, Kopelovich L, Pandolfi PP. Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model. Genes Cancer 2:160-65, 2011.
    [ PubMed Abstract ]
  • Sharma S, Lee J, Gao P, Steele VE. Toxicity profile of solvents by aspiration approach for topical agent delivery to respiratory tract epithelium. Int J Toxicol 30:358-66, 2011.
    [ PubMed Abstract ]
  • Sharma S, Lee J, Zhou J, Steele VE. Chemopreventive efficacy and mechanism of licofelone in a mouse lung tumor model via aspiration. Cancer Prev Res (Phila) 4:1233-42, 2011.
    [ PubMed Abstract ]
  • Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila) 4:329-46, 2011.
    [ PubMed Abstract ]
  • Walsh SB, Xu J, Xu H, Kurundkar AR, Maheshwari A, Grizzle WE, Timares L, Huang CC, Kopelovich L, Elmets CA, Athar M. Cyclosporine A mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: Role of TGFβ signaling pathway. Mol Carcinog 50:516-27, 2011.
    [ PubMed Abstract ]
  • Wang Q, Chaerkady R, Wu J, Hwang HJ, Papadopoulos N, Kopelovich L, Maitra A, Matthaei H, Eshleman JR, Hruban RH, Kinzler KW, Pandey A, Vogelstein B. Mutant proteins as cancer-specific biomarkers. Proc Natl Acad Sci U S A 108:2444-49, 2011.
    [ PubMed Abstract ]
  • Williams JL, Ji P, Ouyang N, Kopelovich L, Rigas B. Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action. Exp Cell Res 317:1359-67, 2011.
    [ PubMed Abstract ]
  • Wu J, Jiao Y, Dal Molin M, Maitra A, de Wilde RF, Wood LD, Eshleman JR, Goggins MG, Wolfgang CL, Canto MI, Schulick RD, Edil BH, Choti MA, Adsay V, Klimstra DS, Offerhaus GJ, Klein AP, Kopelovich L, Carter H, Karchin R, Allen PJ, Schmidt CM, Naito Y, Diaz LA, Jr., Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B. Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proc Natl Acad Sci U S A 108:21188-93, 2011.
    [ PubMed Abstract ]
  • Wu KM, Yao J, Boring D. Green tea extract-induced lethal toxicity in fasted but not in nonfasted dogs. Int J Toxicol 30:19-20, 2011.
    [ PubMed Abstract ]
  • Xie G, Sun Y, Nie T, Mackenzie GG, Huang L, Kopelovich L, Komninou D, Rigas B. Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: Efficacy, metabolism, and pharmacokinetics in mouse models. J Pharmacol Exp Ther 337:876-86, 2011.
    [ PubMed Abstract ]
  • Xu J, Walsh SB, Verney ZM, Kopelovich L, Elmets CA, Athar M. Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway. Biochem Biophys Res Commun 408:363-68, 2011.
    [ PubMed Abstract ]
  • Zhang Q, Pan J, Zhang J, Liu P, Chen R, Chen DR, Lubet R, Wang Y, You M. Aerosolized bexarotene inhibits lung tumorigenesis without increasing plasma triglyceride and cholesterol levels in mice. Cancer Prev Res (Phila) 4:270-76, 2011.
    [ PubMed Abstract ]
  • Agurs-Collins T, Dunn BK, Browne D, Johnson KA, Lubet R. Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer. Semin Oncol 37:384-401, 2010.
    [ PubMed Abstract ]
  • Arun B, Dunn BK, Ford LG, Ryan A. Breast cancer prevention trials: Large and small trials. Semin Oncol 37:367-83, 2010.
    [ PubMed Abstract ]
  • Balansky R, Ganchev G, Iltcheva M, Steele VE, De Flora S. Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteine. Int J Cancer 126:1047-54, 2010.
    [ PubMed Abstract ]
  • Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG. Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila) 3:48-61, 2010.
    [ PubMed Abstract ]
  • Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 70:9003-11, 2010.
    [ PubMed Abstract ]
  • Calzone K, Wattendorf D, Dunn BK. The application of genetics and genomics to cancer prevention. Semin Oncol 37:407-18, 2010.
    [ PubMed Abstract ]
  • Chattopadhyay M, Goswami S, Rodes DB, Kodela R, Velazquez CA, Boring D, Crowell JA, Kashfi K. NO-releasing NSAIDs suppress NF-κB signaling in vitro and in vivo through S-nitrosylation. Cancer Lett 298:204-11, 2010.
    [ PubMed Abstract ]
  • Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila) 3:1168-75, 2010.
    [ PubMed Abstract ]
  • Cwik MJ, Wu H, Muzzio M, McCormick DL, Kapetanovic I. Direct quantitation of glucoraphanin in dog and rat plasma by LC-MS/MS. J Pharm Biomed Anal 52:544-49, 2010.
    [ PubMed Abstract ]
  • Dunn BK, Agurs-Collins T, Browne D, Lubet R, Johnson KA. Health disparities in breast cancer: Biology meets socioeconomic status. Breast Cancer Res Treat 121:281-92, 2010.
    [ PubMed Abstract ]
  • Dunn BK, Greene MH, Kelley JM, Costantino JP, Clifford RJ, Hu Y, Tang G, Kazerouni N, Rosenberg PS, Meerzaman DM, Buetow KH. Novel pathway analysis of genomic polymorphism-cancer risk interaction in the Breast Cancer Prevention Trial. Int J Mol Epidemiol Genet 1:332-49, 2010.
    [ PubMed Abstract ]
  • Dunn BK, Greenwald P. Cancer Prevention II: Introduction. Semin Oncol 37:321-26, 2010.
    [ PubMed Abstract ]
  • Dunn BK, Greenwald P. Cancer prevention I: Introduction. Semin Oncol 37:190-201, 2010.
    [ PubMed Abstract ]
  • Dunn BK, Richmond ES, Minasian LM, Ryan AM, Ford LG. A nutrient approach to prostate cancer prevention: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). Nutr Cancer 62:896-918, 2010.
    [ PubMed Abstract ]
  • Dunn BK, Wagner PD, Anderson D, Greenwald P. Molecular markers for early detection. Semin Oncol 37:224-42, 2010.
    [ PubMed Abstract ]
  • Herbert BS, Chanoux RA, Liu Y, Baenziger PH, Goswami CP, McClintick JN, Edenberg HJ, Pennington RE, Lipkin SM, Kopelovich L. A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers. Oncotarget 1:405-22, 2010.
    [ PubMed Abstract ]
  • Herschkowitz JI, Lubet R. Mouse models of triple negative [basal-like/claudin low breast cancer. Breast Dis 32:63-71, 2010.
    [ PubMed Abstract ]
  • Izzotti A, Calin GA, Steele VE, Cartiglia C, Longobardi M, Croce CM, De Flora S. Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs. Cancer Prev Res (Phila) 3:62-72, 2010.
    [ PubMed Abstract ]
  • Izzotti A, Larghero P, Cartiglia C, Longobardi M, Pfeffer U, Steele VE, De Flora S. Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung. Carcinogenesis 31:894-901, 2010.
    [ PubMed Abstract ]
  • Janakiram NB, Mohammed A, Zhang Y, Choi CI, Woodward C, Collin P, Steele VE, Rao CV. Chemopreventive effects of Frondanol A5, a Cucumaria frondosa extract, against rat colon carcinogenesis and inhibition of human colon cancer cell growth. Cancer Prev Res (Phila) 3:82-91, 2010.
    [ PubMed Abstract ]
  • Kadota M, Yang HH, Gomez B, Sato M, Clifford RJ, Meerzaman D, Dunn BK, Wakefield LM, Lee MP. Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines. PLoS One 5:e9201, 2010.
    [ PubMed Abstract ]
  • Kapetanovic IM, Horn TL, Johnson WD, Cwik MJ, Detrisac CJ, McCormick DL. Murine oncogenicity and pharmacokinetics studies of 9-cis-UAB30, an RXR agonist, for breast cancer chemoprevention. Int J Toxicol 29:157-64, 2010.
    [ PubMed Abstract ]
  • Kapetanovic IM, Muzzio M, Hu SC, Crowell JA, Rajewski RA, Haslam JL, Jong L, McCormick DL. Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys. Cancer Chemother Pharmacol 65:1109-16, 2010.
    [ PubMed Abstract ]
  • Lee KM, Lee KW, Jung SK, Lee EJ, Heo YS, Bode AM, Lubet RA, Lee HJ, Dong Z. Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity. Biochem Pharmacol 80:2042-49, 2010.
    [ PubMed Abstract ]
  • Lindeblad M, Kapetanovic IM, Kabirov KK, Detrisac CJ, Dinger N, Mankovskaya I, Zakharov A, Lyubimov AV. Assessment of oral toxicity and safety of pentamethylchromanol (PMCol), a potential chemopreventative agent, in rats and dogs. Toxicology 273:19-28, 2010.
    [ PubMed Abstract ]
  • Lindeblad MO, Bauer KS, Zakharov AD, Hill JM, Green JS, Thomas BF, Schwartz A, Kapetanovic IM, Lyubimov A. Pharmacokinetic and tissue distribution study of [14C] fluasterone in male Beagle dogs following intravenous, oral and subcutaneous dosing routes. Chem Biol Interact 183:317-26, 2010.
    [ PubMed Abstract ]
  • Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB. Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Cancer Prev Res (Phila) 3:597-603, 2010.
    [ PubMed Abstract ]
  • Lu Y, Liu P, Wen W, Grubbs CJ, Townsend RR, Malone JP, Lubet RA, You M. Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. Am J Transl Res 3:8-27, 2010.
    [ PubMed Abstract ]
  • Lubet RA, Steele VE, Juliana MM, Grubbs CJ. Screening agents for preventive efficacy in a bladder cancer model: Study design, end points, and gefitinib and naproxen efficacy. J Urol 183:1598-1603, 2010.
    [ PubMed Abstract ]
  • Mackenzie GG, Sun Y, Huang L, Xie G, Ouyang N, Gupta RC, Johnson F, Komninou D, Kopelovich L, Rigas B. Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice. Gastroenterology 139:1320-32, 2010.
    [ PubMed Abstract ]
  • McCormick DL, Phillips JM, Horn TL, Johnson WD, Steele VE, Lubet RA. Overexpression of cyclooxygenase-2 in rat oral cancers and prevention of oral carcinogenesis in rats by selective and nonselective COX inhibitors. Cancer Prev Res (Phila) 3:73-81, 2010.
    [ PubMed Abstract ]
  • McCormick DL, Rao KV, Johnson WD, Bosland MC, Lubet RA, Steele VE. Null activity of selenium and vitamin E as cancer chemopreventive agents in the rat prostate. Cancer Prev Res (Phila) 3:381-92, 2010.
    [ PubMed Abstract ]
  • Mohammed A, Janakiram NB, Li Q, Madka V, Ely M, Lightfoot S, Crawford H, Steele VE, Rao CV. The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model. Cancer Prev Res (Phila) 3:1417-26, 2010.
    [ PubMed Abstract ]
  • Nath N, Chattopadhyay M, Kodela R, Tian S, Vlismas P, Boring D, Crowell JA, Kashfi K. Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells. Biochem Pharmacol 79:1759-71, 2010.
    [ PubMed Abstract ]
  • Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res 70:7392-99, 2010.
    [ PubMed Abstract ]
  • Pollock CB, Rodriguez O, Martin PL, Albanese C, Li X, Kopelovich L, Glazer RI. Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation. PPAR Res 2010:571783, 2010.
    [ PubMed Abstract ]
  • Saleiro D, Murillo G, Lubahn DB, Kopelovich L, Korach KS, Mehta RG. Enhanced induction of mucin-depleted foci in estrogen receptor Β knockout mice. Cancer Prev Res (Phila) 3:1198-1204, 2010.
    [ PubMed Abstract ]
  • Sharma S, Gao P, Steele VE. Quantitative morphometry of respiratory tract epithelial cells as a tool for testing chemopreventive agent efficacy. Anticancer Res 30:737-42, 2010.
    [ PubMed Abstract ]
  • Steele VE, Lubet RA. The use of animal models for cancer chemoprevention drug development. Semin Oncol 37:327-38, 2010.
    [ PubMed Abstract ]
  • Tang JY, Aszterbaum M, Athar M, Barsanti F, Cappola C, Estevez N, Hebert J, Hwang J, Khaimskiy Y, Kim A, Lu Y, So PL, Tang X, Kohn MA, McCulloch CE, Kopelovich L, Bickers DR, Epstein EH, Jr. Basal cell carcinoma chemoprevention with nonsteroidal anti-inflammatory drugs in genetically predisposed PTCH1+/- humans and mice. Cancer Prev Res (Phila) 3:25-34, 2010.
    [ PubMed Abstract ]
  • Umar A, Della'Zanna G, Lubet R. Further thoughts on preclinical animal models for cancer prevention: When is it best to start treatment? What are potential histopathologic endpoints? Semin Oncol 37:339-44, 2010.
    [ PubMed Abstract ]
  • Wang Y, James M, Wen W, Lu Y, Szabo E, Lubet RA, You M. Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. Mol Cancer Ther 9:3074-82, 2010.
    [ PubMed Abstract ]
  • Xu J, Timares L, Heilpern C, Weng Z, Li C, Xu H, Pressey JG, Elmets CA, Kopelovich L, Athar M. Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis. Cancer Res 70:6566-76, 2010.
    [ PubMed Abstract ]
  • Yang HH, Hu N, Wang C, Ding T, Dunn BK, Goldstein AM, Taylor PR, Lee MP. Influence of genetic background and tissue types on global DNA methylation patterns. PLoS One 5:e9355, 2010.
    [ PubMed Abstract ]
  • Zhang Q, Fu H, Pan J, He J, Ryota S, Hara Y, Wang Y, Lubet RA, You M. Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice. Pharm Res 27:1066-71, 2010.
    [ PubMed Abstract ]

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