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Breast and Gynecologic Cancer Research Group

Key Programs

Publications

The ASCUS/LSIL Triage Study for Cervical Cancer (ALTS)

2006

  • Walker J, Wang SS, Schiffman M, Solomon D, for the ALTS Group. Risks and relative risks of CIN3 following colposcopy, related to visual, cytologic, and virologic data. Am J Obstet Gynecol, 2006;195:341-48.
  • Kreimer AR, Guido RS, Solomon D, Schiffman M, et al. HPV testing predicts women at risk for recurrent cervical intraepithelial neoplasia grade 2 or 3 disease following loop electrosurgical excision procedure. Cancer Epidemiol Biomarkers Prev 2006;15:908-14.
  • Gage JC, Hanson VW, Abbey K, Dippery S, Gardner S, Kubota J, Schiffman M, Solomon D, Jeronimo J for the ALTS Group. Evidence that taking more cervical biopsies substantially improves the sensitivity of colposcopically-guided biopsies. Obstet Gynecol 2006;108:264-72.
  • Ferris, Prediction of cervical histologic results using the Reid Colposcopic Index during ALTS. AJOG, 2006;194:704-10.
  • Atkins KA, Jeronimo J, Stoler MH. Description of patients with squamous cell carcinoma in the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion triage study. Cancer Cytopathol. 2006;108:212-21.
  • Sherman ME, Carreon JD, Schiffman M. Performance of cytology and human papillomavirus testing in relation to the menstrual cycle. Br J Cancer. 2006 May 2; [epub].
  • Sherman ME, Castle PE, Solomon D. Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomes. Cancer. 2006 Mar 16; [Epub ahead of print].
  • Ferris DG, Litaker MS; ALTS Group. Prediction of cervical histologic results using an abbreviated Reid Colposcopic Index during ALTS. Am J Obstet Gynecol. 2006. Mar;194(3):704-10.
  • Kulasingam SL, Kim JJ, Lawrence WF, Mandelblatt JS, Myers ER, Schiffman M,
    Solomon D, Goldie SJ; ALTS Group. Cost-effectiveness analysis based on the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion Triage Study (ALTS). J Natl Cancer Inst. 2006 Jan 18;98(2):92-100.

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2005

  • Wang SS, Medication use, medical conditions and the risk of human papillomavirus infection and subsequent CIN3 among women with mild cytologic abnormalities. Cancer Epidemiol Biomarkers Prevention 2005;14:542-5.
  • Wang SS, Estimating the risk of CIN3 using a combination of cytologic, virologic, and visual methods Cancer Epidemiol Biomarkers Prevention 2005;14:2665-8.
  • Castle, HPV type 16 infections and 2-year absolute risk of cervical precancer among women with equivocal or mild cytologic abnormalities. J Natl Cancer Inst 2005;97:1066-71.
  • Guido, Location of lesions in ALTS, demonstrates that most lesions are anterior or posterior. AJOG 2005, in press.
  • Henao, Folate is associated with the natural history of high-risk human papillomavirus. Int J Cancer 2005;113:991-7.
  • Schiffman M, Wheeler CM, Dasgupta A, Solomon D, Castle PE; The ALTS Group. A comparison of a prototype PCR assay and hybrid capture 2 for detection of carcinogenic human papillomavirus DNA in women with equivocal or mildly abnormal papanicolaou smears. Am J Clin Pathol. 2005 Nov;124(5):722-32.
  • Guido RS, Jeronimo J, Schiffman M, Solomon D; ALTS Group. The distribution of neoplasia arising on the cervix: results from the ALTS trial. Am J Obstet Gynecol. 2005 Oct;193(4):1331-7.
  • Srodon M, Parry Dilworth H, Ronnett BM. Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion: diagnostic performance, human papillomavirus testing, and follow-up results. Cancer. 2006 Feb 25;108(1):32-8. (comparison of ALTS data).
  • Zuna RE, Wang SS, Rosenthal DL, Jeronimo J, Schiffman M, Solomon D; ALTS
    Group. Determinants of human papillomavirus-negative, low-grade squamous intraepithelial lesions in the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesions triage study (ALTS). Cancer Cytopathology. 2005 Oct 25;105(5):253-62.
  • Castle PE, Walker JL, Schiffman M, Wheeler CM. Hormonal contraceptive use, pregnancy and parity, and the risk of cervical intraepithelial neoplasia 3 among oncogenic HPV DNA-positive women with equivocal or mildly abnormal cytology. Int J Cancer. 2005 Dec 20;117(6):1007-12.
  • McIntyre-Seltman K, Castle PE, Guido R, Schiffman M, Wheeler CM; ALTS Group. Smoking is a risk factor for cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology. Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1165-70.
  • Khan MJ, Partridge EE, Wang SS, Schiffman M. Socioeconomic status and the risk of cervical intraepithelial neoplasia grade 3 among oncogenic human papillomavirus DNA-positive women with equivocal or mildly abnormal cytology. Cancer. 2005 Jul 1;104(1):61-70.
  • Ferris DG, Litaker M; ALTS Group. Interobserver agreement for colposcopy quality control using digitized colposcopic images during the ALTS trial. J Low Genit Tract Dis. 2005 Jan; 9(1):29-35.
  • Jeronimo J, Khan MJ, Schiffman M, Solomon D; ALTS Group. Does the interval between papanicolaou tests influence the quality of cytology? Cancer. 2005 Jun 25;105(3):133-8.
  • Schiffman M, Khan MJ, Solomon D, Herrero R, Wacholder S, Hildesheim A, Rodriguez AC, Bratti MC, Wheeler CM, Burk RD; PEG Group; ALTS Group. A study of the impact of adding HPV types to cervical cancer screening and triage tests. J Natl Cancer Inst. 2005 Jan 19;97(2):147-50.

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2004

  • Castle, Hybrid Capture 2 viral load and the 2-year cumulative risk of CIN 3 or cancer. AJOG 2004;191:1590-7.
  • Piyathilake C. Folate (one-carbon metabolism biomarkers) as a co-factor, based on blood, questionnaire, and related polymorphisms. Cancer Research 2004;64:8788-93.
  • Ferris DG, Litaker MS; ASCUS/LSIL Triage Study (ALTS) Group. Colposcopy quality control by remote review of digitized colposcopic images. Am J Obstet Gynecol. 2004 Dec;191(6):1934-41.
  • Castle PE, Wheeler CM, Solomon D, Schiffman M, Peyton CL; ALTS Group. Interlaboratory reliability of Hybrid Capture 2. Am J Clin Pathol. 2004 Aug;122(2):238-45.

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2003

  • Sherman, Histopathologic extent of CIN 3 lesions in the ASCUS LSIL Triage Study (ALTS): implications for subject safety and lead-time bias. Cancer Epid Biomarkers Prevent 2003;12:372-9.
  • Sherman, Determinants of HPV viral load among women with histologic CIN 3: dominant impact of surrounding low-grade lesions. Cancer Epid Biomarkers Prevent 2003;12:1038-44.
  • Lorincz AT. Screening for cervical cancer: new alternatives and research. Salud Publica Mex. 2003;45 Suppl 3:S376-87. Review.
  • Stoler MH. Testing for human papillomavirus: data driven implications for cervical
    neoplasia management. Clin Lab Med. 2003 Sep;23(3):569-83, v. Review.
  • Cox JT; American Society for Colposcopy and Cervical Pathology. The clinician's view: role of human papillomavirus testing in the American Society for Colposcopy and Cervical Pathology Guidelines for the management of abnormal cervical cytology and cervical cancer precursors. Arch Pathol Lab Med. 2003 Aug;127(8):950-8.
  • Schiffman M, Solomon D. Findings to date from the ASCUS-LSIL Triage Study (ALTS). Arch Pathol Lab Med. 2003 Aug;127(8):946-9. Review.
  • Cox JT, Schiffman M, Solomon D; ASCUS-LSIL Triage Study (ALTS) Group.
    Prospective follow-up suggests similar risk of subsequent cervical intraepithelial neoplasia grade 2 or 3 among women with cervical intraepithelial neoplasia grade 1 or negative colposcopy and directed biopsy. Am J Obstet Gynecol. 2003 Jun;188(6):1406-12.
  • Guido R, Schiffman M, Solomon D, Burke L; ASCUS LSIL Triage Study (ALTS)
    Group. Postcolposcopy management strategies for women referred with low-grade squamous intraepithelial lesions or human papillomavirus DNA-positive atypical squamous cells of undetermined significance: a two-year prospective study. Am J Obstet Gynecol. 2003 Jun;188(6):1401-5.
  • ASCUS-LSIL Traige Study (ALTS) Group. A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations. Am J Obstet Gynecol. 2003 Jun;188(6):1393-400.
  • ASCUS-LSIL Traige Study (ALTS) Group. Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined significance. Am J Obstet Gynecol. 2003 Jun;188(6):1383-92.
  • Monk BJ, Brewster WR. Does the ALTS trial apply to the community-based practitioner? Am J Obstet Gynecol. 2003 Jun;188(6):1381-2.

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2002

  • Solomon D, Schiffman M, Tarone R. ASCUS LSIL Triage Study (ALTS) conclusions reaffirmed: response to a November 2001 commentary. Obstet Gynecol. 2002 Apr;99(4):671-4. No abstract available.
  • Castle PE, Hildesheim A, Bowman FP, Strickler HD, Walker JL, Pustilnik T, Edwards RP, Crowley-Nowick PA. Cervical concentrations of interleukin-10 and interleukin-12 do not correlate with plasma levels. J Clin Immunol. 2002 Jan;22(1):23-7.
  • Sherman ME, Schiffman M, Cox JT; Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study Group. Effects of age and human papilloma viral load on colposcopy triage: data from the randomized Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS). J Natl Cancer Inst. 2002 Jan 16;94(2):102-7.

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2001

  • Herbst AL, Pickett KE, Follen M, Noller KL. The management of ASCUS cervical cytologic abnormalities and HPV testing: a cautionary note. Obstet Gynecol. 2001 Nov;98(5 Pt 1):849-51.
  • Ferris DG, Schiffman M, Litaker MS. Cervicography for triage of women with mildly abnormal cervical cytology results. Am J Obstet Gynecol. 2001 Oct;185(4):939-43.
  • Stoler MH, Schiffman M; Atypical Squamous Cells of Undetermined Significance-Low-grade Squamous Intraepithelial Lesion Triage Study (ALTS) Group. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-LSIL Triage Study. JAMA. 2001 Mar 21;285(11):1500-5.
  • Solomon D, Schiffman M, Tarone R; ALTS Study group. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial. J Natl Cancer Inst. 2001 Feb 21;93(4):293-9.

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2000

  • Schiffman M, Adrianza ME. ASCUS-LSIL Triage Study. Design, methods and characteristics of trial participants. Acta Cytol. 2000 Sep-Oct;44(5):726-42.
  • [No authors listed] Human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial. The Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (ALTS) Group. J Natl Cancer Inst. 2000 Mar 1;92(5):397-402.