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Vitamin D and Cancer: Current Dilemas/Future Needs

Meeting Date

May 07 - 08, 2007

Meeting Location

Lister Hill Auditorium
First Floor, Lister Hill Center, Building 38A
National Institutes of Health
8600 Rockville Pike (at Center Drive)
Bethesda, MD 20894

Meeting Objectives

  • To evaluate the scientific evidence related to vitamin D and cancer risk.
  • Identify gaps in knowledge and determine the research needed to make science-based recommendations for vitamin D intake/exposure for cancer prevention.
  • The conference topics covered included the relative importance of sunlight exposure and diet as sources of vitamin D; the epidemiological evidence of the nature and strength of the association between vitamin D and cancer risk; how nutrigenetics has advanced our understanding of the relationship between vitamin D and cancer risk; discussion of new information about the role of genes and cross-talk among genes that may influence the response to vitamin D; the interrelationship between vitamin D and other dietary components that may modify the response; and information provided by preclinical models about the relationship between vitamin D and cancer.

Meeting Materials

Presentations

Name Presentation
Schwartz, Gary, PhD, MPH, PhD
Associate Professor, Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine

Setting the Stage: What are the Critical Factors for Evaluating Sunlight and Dietary Vitamin D and Cancer Risk?

Giovannucci, Ed, MD, ScD
Professor, Nutrition and Epidemiology, Harvard School of Public Health

What are the Strengths and Limitations of Current Epidemiologic Studies Investigating Vitamin D Intake and Status as a Modifier of Breast Cancer Risk?

Rohan, Thomas, MD, PhD
Chairman, Epidemiology and Population Health, Albert Einstein School of Medicine

What are the Strengths and Limitationsof Current Epidemiologic Studies of Vitamin D Intake and Status as a Modifier of Breast Cancer Risk? (ppt, 120kb)

Tucker, Margaret, MD
Director, Human Genetics Program, Genetic Epidemiology Branch, DCEG, National Cancer Institute
What are the Strengths and Limitations of Current Assessment Tools for Sunlight Exposure in Populations? (ppt, 1.77mb)
Hollis, Bruce, PhD
Professor, Pediatrics, Biochemistry and Molecular Biology, Medical University of South Carolina

What are the Strengths and Limitations of Current Assessment Tools for Vitamin D Status in Populations? (ppt, 2.74mb)

Garland, Cedric, DrPH
Professor, Department of Family and Preventive Medicine, University of California San Diego School of Medicine

What is the Dose Response Relationship Between Vitamin D Statusand Cancer? (ppt, 1.35mb)

Rukin, Nicholas, MBChB
Urology Research Fellow, Department of Urological Surgery, Keele University Medical School

What are the Frequency, Distribution and Functional Effects of Vitamin D Receptor Polymorphisms as Related to Cancer Risk? (ppt, 317kb)

Slattery, Martha, PhD
Professor, Internal Medicine, University of Utah

What is the Evidence That Genetic Polymorphisms in the Vitamin D Receptor Influence Cancer Risk? Are There Ethnic Differences in These Polymorphisms and are These Related to Cancer Risk? (pdf, 32kb)

Ingles, Sue, DrPH
Associate Professor, Preventive Medicine, University of Southern California

Can Diet and/or Sunlight Exposure Influence the Relationship Between Vitamin D Receptor Polymorphisms and Cancer Risk? (ppt, 2.85mb)

Cross, Heide S., PhD
AssociateProfessor, Pathophysiology, Medical University of Vienna

What is the Role of Extra-Renal Vitamin D Hydroxylase Expression and Activity in Normal and MalignantCells? How is this Modified by Epigenetic Mechanisms and Dietary Factors? (ppt, 18.53mb)

Feldman, David, MD
Professor, Medicine/Endocrinology, Stanford University School of Medicine

What is the Role of Vitamin D Mediated Inhibition of Prostaglandin Metabolism on Cancer Risk?

Weigel, Nancy, PhD
Professor, Molecular and Cellular Biology, Baylor College of Medicine

What is the Role of the Androgen Receptor in Mediating the Effects of Vitamin D? (ppt, 968kb)

Byers, Stephen, PhD
Professor, Oncology, Georgetown University

What is the Molecular Basis of VitaminD Receptor and β-catenin Cross-Regulation? (ppt, 3.69mb)

Cross, Heide S., PhD
Associate Professor, Pathophysiology, Medical University of Vienna

How do Dietary Calcium, Folate, and Soy Regulate Colonic Vitamin D Synthesis? (ppt, 22.81mb)

Krishnan, Aruna, PhD
Senior Research Scientist, Medicine, Division of Endocrinology, Stanford University

What is the Molecular Mechanism Whereby Genistein Poteniates the Growth Inhibitory Effects of Vitamin D?

Looker, Ann, PhD
Senior Scientist, Centers for Disease Control, National Center for Health Statistics

How do Body Fat and Exercise Modulate Vitamin D Status? Do Ethnic Differences Modify this Relationship? (ppt, 89kb)

Fleet, James, PhD
Professor, Department of Foods and Nutrition, Purdue University

What have Genomic and Proteomic Approaches Told Us About Vitamin D and Cancer?

Welsh, JoEllen, PhD
Professor, Biological Sciences, University of Notre Dame

What is the Role of Dietary Calcium And Vitamin D in Vitamin D Receptor Knockout Animals? (ppt, 26.76mb)

Augenlicht, Lenord, BA, PhD
Professor, Associate Director, Medicine and Cell Biology, Albert Einstein Cancer Center

What are the Molecular Targets for Calcium and Vitamin D in Mouse Genetic Models for Cancer?


Point of Contact

Cindy Davis, PhD
Program Director
Nutritional Science Research Group
Division of Cancer Prevention
National Cancer Institute, NIH, DHHS
6130 Executive Boulevard
Suite 3159
Rockville, MD 20892
Phone: (301) 594-9692
Fax: (301) 480-3925
E-mail: davisci@mail.nih.gov

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