May 07, 2007
| 7:30 - 8:00 am | Registration |
| 8:00 - 8:05 am | Welcome | Cindy Davis
National Cancer Institute |
| 8:05 - 8:25 am | Opening Remarks |
Peter Greenwald
DCP
National Cancer Institute
Robert Croyle
DCCPS
National Cancer Institute
Joseph Fraumeni
DCEG
National Cancer Institute
Paul Coates
Office of Dietary Supplements |
I Setting the Stage: How strong is the evidence that vitamin D status is related to cancer risk?
Moderator: Virginia Hartmuller |
| 8:25 - 8:45 am |
Setting the stage: What are the critical factors for evaluating sunlight and dietary vitamin D and cancer risk? | Gary Schwartz
Wake Forest University |
| 8:45 - 8:55 am |
Discussion |
| 8:55 - 9:15 am |
What are the strengths/limitations of current epidemiologic studies investigating vitamin D intake/status as a modifier of colon and prostate cancer risk? | Ed Giovannucci
Harvard |
| 9:15 - 9:25 am |
Discussion |
| 9:25 - 9:45 am |
What are the strengths/limitations of current epidemiologic studies of vitamin D intake/status as a modifier of breast cancer risk? | Thomas Rohan
Albert Einstein School of Medicine |
| 9:45 - 9:55 am |
Discussion |
| 9:55 - 10:15 am |
What are the strengths/limitations of current assessment tools for sunlight exposure in populations? | Margaret Tucker
National Cancer Institute |
| 10:15 - 10:25 am |
Discussion |
| 10:25 - 10:45 am |
Break |
| 10:45 - 11:05 am |
What are the strengths/limitations of current assessment tools for vitamin D status in populations? | Bruce Hollis
Medical University of South Carolina |
| 11:05 - 11:15 am |
Discussion |
| 11:15 - 11:30 am |
What is the dose response relationship between vitamin D status and cancer? | Cedric Garland
University of California
San Diego |
| 11:30 - 11:35 am |
Discussion |
|
11:35 am - 12:05 pm | Group Discussion: How strong is the evidence and what are the current research gaps? |
Moderator: Arthur Schatzkin |
| 12:05 - 1:00 pm | Lunch |
II How has nutrigenetics advanced our understanding of the relationship between vitamin D and cancer risk?
Moderator: Michal Freedman |
| 1:00 - 1:20 pm |
What are the frequency
distribution and functional effects of vitamin D receptor polymorphisms as related to cancer risk? | Nicholas Rukin
University of North Staffordshire |
| 1:20 - 1:30 pm |
Discussion |
| 1:30 - 1:50 pm |
What is the evidence that genetic polymorphisms in the vitamin D receptor influence cancer risk? Are there ethnic differences in these polymorphisms and are these related to cancer risk? | Martha Slattery
University of Utah |
| 1:50 - 2:00 pm |
Discussion |
| 2:00 - 2:20 pm |
Can diet and/or sunlight exposure influence the relationship between vitamin D receptor polymorphisms and cancer risk? | Sue Ingles
University of Southern California |
| 2:20 - 2:30 pm |
Discussion |
| 2:30 - 2:50 pm |
Group Discussion: What are the current research gaps? | Moderator: Walter Willett
Harvard |
| 2:50 - 3:10 pm |
Break |
III What other genes determine the response to vitamin D?
Moderator: Patricia Hartge |
| 3:10 - 3:30 pm | What is the role of exta-renal vitamin D hydroxylase expression and activity in normal and malignant cells? How is this modified by epigenetic mechanisms and dietary factors?
| Heide S Cross
Medical University of Vienna |
| 3:30 - 3:40 pm | Discussion |
| 3:40 - 4:00 pm | What is the role of vitamin D mediated inhibition of prostaglandin metabolism on cancer
risk? | David Feldman
Stanford University |
| 4:00 - 4:10 pm | Discussion |
| 4:10 - 4:30 pm | What is the role of the androgen receptor in mediating the effects of vitamin D? | Nancy
Weigel
Baylor College of Medicine |
| 4:30 - 4:40 pm | Discussion |
| 4:40 - 5:00 pm | What is the molecular basis of vitamin D receptor and ß-catenin cross-regulation? |
Stephen Byers
Georgetown University |
| 5:00 - 5:10 pm | Discussion |
| 5:10 - 5:30 pm | Group Discussion: What are the current research gaps?
| Moderator: Hector DeLuca
University of Wisconsin - Madison |
| 5:30 pm | Adjourn |
Tentative Agenda—Day 2
May 08, 2007
IV What are the important dietary components that modify the effect of Vitamin D?
Moderator: Mary Frances Picciano |
| 8:00 - 8:20 am |
How do dietary calcium folate and soy regulate colonic vitamin D synthesis | Heide S Cross
Medical University of Vienna |
| 8:20 - 8:30 am |
Discussion |
| 8:30 - 8:50 am |
What is the molecular mechanism whereby genistein poteniates the growth inhibitory effects of vitamin D? | Aruna Krishnan
Stanford University |
| 8:50 - 9:00 am |
Discussion |
| 9:00 - 9:20 am |
How do body fat and exercise modulate vitamin D status? Do ethnic differences modify this relationship? | Ann Looker
National Center for Health Statistics |
| 9:20 - 9:30 am |
Discussion |
| 9:30 - 9:50 am |
Group Discussion: What are the current research gaps? | Moderator: Margherita Cantorna
Penn State University |
| 9:50 - 10:10 am |
Break |
V What information have preclinical models provided about the relationship between vitamin D calcium and cancer?
Moderator: Cindy Davis |
| 10:10 - 10:30 am | What have genomic and proteomic approaches told us about vitamin D and cancer? |
James Fleet
Purdue University |
| 10:30 - 10:40 am | Discussion |
| 10:40 - 11:00 am | What is the role of dietary calcium and vitamin D in vitamin D receptor knockout
animals? | JoEllen Welsh
University of Notre Dame |
| 11:00 - 11:10 am | Discussion |
| 11:10 - 11:30 am | What are the molecular targets for calcium and vitamin D in mouse genetic models for cancer? | Len Augenlicht
Albert Einstein Cancer Center |
| 11:30 - 11:40 am | Discussion |
| 11:40 am - 12:00 pm | Group Discussion: What are the current research gaps? | Moderator: Anthony Norman
University of California, Riverside |
| 12:00 - 1:00 pm | Lunch |
VI Future Directions: Setting research priorities
Moderator: Peter Greenwald |
| 1:00 - 1:45 pm |
Group Discussion: What are the critical issues for future studies investigating vitamin D and cancer? | Session Moderators |
| 1:45 - 2:00 pm |
Summary Comments | Cindy Davis and Virginia Hartmuller |
| 2:00 pm | Adjourn |
