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Vitamin D and Cancer: Current Dilemas/Future Needs
May 07, 2007
7:30 - 8:00 amRegistration
8:00 - 8:05 amWelcomeCindy Davis
National Cancer Institute
8:05 - 8:25 amOpening Remarks Peter Greenwald
DCP
National Cancer Institute
Robert Croyle
DCCPS
National Cancer Institute
Joseph Fraumeni
DCEG
National Cancer Institute
Paul Coates
Office of Dietary Supplements
I Setting the Stage: How strong is the evidence that vitamin D status is related to cancer risk?
Moderator: Virginia Hartmuller
8:25 - 8:45 am Setting the stage: What are the critical factors for evaluating sunlight and dietary vitamin D and cancer risk?Gary Schwartz
Wake Forest University
8:45 - 8:55 am Discussion
8:55 - 9:15 am What are the strengths/limitations of current epidemiologic studies investigating vitamin D intake/status as a modifier of colon and prostate cancer risk?Ed Giovannucci
Harvard
9:15 - 9:25 am Discussion
9:25 - 9:45 am What are the strengths/limitations of current epidemiologic studies of vitamin D intake/status as a modifier of breast cancer risk?Thomas Rohan
Albert Einstein School of Medicine
9:45 - 9:55 am Discussion
9:55 - 10:15 am What are the strengths/limitations of current assessment tools for sunlight exposure in populations?Margaret Tucker
National Cancer Institute
10:15 - 10:25 am Discussion
10:25 - 10:45 am Break
10:45 - 11:05 am What are the strengths/limitations of current assessment tools for vitamin D status in populations?Bruce Hollis
Medical University of South Carolina
11:05 - 11:15 am Discussion
11:15 - 11:30 am What is the dose response relationship between vitamin D status and cancer?Cedric Garland
University of California
San Diego
11:30 - 11:35 am Discussion
11:35 am - 12:05 pmGroup Discussion: How strong is the evidence and what are the current research gaps? Moderator: Arthur Schatzkin
12:05 - 1:00 pmLunch
II How has nutrigenetics advanced our understanding of the relationship between vitamin D and cancer risk?
Moderator: Michal Freedman
1:00 - 1:20 pm What are the frequency
distribution and functional effects of vitamin D receptor polymorphisms as related to cancer risk?
Nicholas Rukin
University of North Staffordshire
1:20 - 1:30 pm Discussion
1:30 - 1:50 pm What is the evidence that genetic polymorphisms in the vitamin D receptor influence cancer risk? Are there ethnic differences in these polymorphisms and are these related to cancer risk?Martha Slattery
University of Utah
1:50 - 2:00 pm Discussion
2:00 - 2:20 pm Can diet and/or sunlight exposure influence the relationship between vitamin D receptor polymorphisms and cancer risk? Sue Ingles
University of Southern California
2:20 - 2:30 pm Discussion
2:30 - 2:50 pm Group Discussion: What are the current research gaps?Moderator: Walter Willett
Harvard
2:50 - 3:10 pm Break
III What other genes determine the response to vitamin D?
Moderator: Patricia Hartge
3:10 - 3:30 pmWhat is the role of exta-renal vitamin D hydroxylase expression and activity in normal and malignant cells? How is this modified by epigenetic mechanisms and dietary factors? Heide S Cross
Medical University of Vienna
3:30 - 3:40 pmDiscussion
3:40 - 4:00 pmWhat is the role of vitamin D mediated inhibition of prostaglandin metabolism on cancer risk?David Feldman
Stanford University
4:00 - 4:10 pmDiscussion
4:10 - 4:30 pmWhat is the role of the androgen receptor in mediating the effects of vitamin D?Nancy Weigel
Baylor College of Medicine
4:30 - 4:40 pmDiscussion
4:40 - 5:00 pmWhat is the molecular basis of vitamin D receptor and ß-catenin cross-regulation? Stephen Byers
Georgetown University
5:00 - 5:10 pmDiscussion
5:10 - 5:30 pmGroup Discussion: What are the current research gaps? Moderator: Hector DeLuca
University of Wisconsin - Madison
5:30 pmAdjourn

Tentative Agenda—Day 2
May 08, 2007
IV What are the important dietary components that modify the effect of Vitamin D?
Moderator: Mary Frances Picciano
8:00 - 8:20 am How do dietary calcium folate and soy regulate colonic vitamin D synthesisHeide S Cross
Medical University of Vienna
8:20 - 8:30 am Discussion
8:30 - 8:50 am What is the molecular mechanism whereby genistein poteniates the growth inhibitory effects of vitamin D?Aruna Krishnan
Stanford University
8:50 - 9:00 am Discussion
9:00 - 9:20 am How do body fat and exercise modulate vitamin D status? Do ethnic differences modify this relationship?Ann Looker
National Center for Health Statistics
9:20 - 9:30 am Discussion
9:30 - 9:50 am Group Discussion: What are the current research gaps?Moderator: Margherita Cantorna
Penn State University
9:50 - 10:10 am Break
V What information have preclinical models provided about the relationship between vitamin D calcium and cancer?
Moderator: Cindy Davis
10:10 - 10:30 amWhat have genomic and proteomic approaches told us about vitamin D and cancer? James Fleet
Purdue University
10:30 - 10:40 amDiscussion
10:40 - 11:00 amWhat is the role of dietary calcium and vitamin D in vitamin D receptor knockout animals?JoEllen Welsh
University of Notre Dame
11:00 - 11:10 amDiscussion
11:10 - 11:30 amWhat are the molecular targets for calcium and vitamin D in mouse genetic models for cancer?Len Augenlicht
Albert Einstein Cancer Center
11:30 - 11:40 amDiscussion
11:40 am - 12:00 pmGroup Discussion: What are the current research gaps? Moderator: Anthony Norman
University of California, Riverside
12:00 - 1:00 pmLunch
VI Future Directions: Setting research priorities
Moderator: Peter Greenwald
1:00 - 1:45 pm Group Discussion: What are the critical issues for future studies investigating vitamin D and cancer?Session Moderators
1:45 - 2:00 pm Summary CommentsCindy Davis and Virginia Hartmuller
2:00 pmAdjourn


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