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NCI's 3rd Annual Early Detection Research Network (EDRN) Scientific Workshop

Agenda

Monday, June 14, 2004
7:00 - 8:00 amRegistration and Continental Breakfast
8:00 - 8:10 amWelcome Peter Greenwald, MD, National Cancer Institute Sudhir Srivastava, PhD, National Cancer Institute
8:10 - 8:30 amNCI Director's Address Andrew von Eschenbach, MD, National Cancer Institute
8:30 - 8:50 amA Cancer Survivor's Perspective Ms Vickie Maye, The Hodgkin's United Group, Irish Cancer Society and NCI's All Ireland Consortium, Dublin, Ireland
8:50 - 10:20 amSession I: Biology of Early Cancer: How Early Is Early? Co-chairs:
Wilbur Franklin, MD, University of Colorado HSC
Adi Gazdar, MD, UT Southwestern Medical Center at Dallas
Sudhir Srivastava, PhD, National Cancer Institute

Presentations:
Molecular and Cellular Events in the Multi-Step Development of Human Cancer
Scott E Kern, MD, Johns Hopkins University School of Medicine
Specific Example and Proven Benefits of Early Detection
Brian J Reid, MD, PhD, Fred Hutchinson Cancer Research Center
Bench to Bedside Direct: EGFR Mutations and the Pathogenesis of Lung Cancers
Adi Gazdar, MD, UT Southwestern Medical Center at Dallas & Wilbur Franklin, MD, University of Colorado HSC
10:20 - 10:30 amBreak
10:30 am - 12:30 pmSession II: Enabling Technologies for Cancer Detection Co-chairs:
Mel Tockman, MD, PhD, H Lee Moffitt Cancer Center
Jeffrey Marks, PhD, Duke University Medical Center
Mukesh Verma, PhD, National Cancer Institute

Presentations:
High-Throughput Sequenced-Based Mutational Profiling
Richard K Wilson, PhD, Washington University School of Medicine
Molecular Cantilevers for PSA
Richard Cote, MD, University of Southern California
3D Cell Tomography for High-Throughput Orientation Independent Feature Analysis
Alan C Nelson, PhD, VisionGate, Inc
Panel Discussion
12:30 - 2:30 pmLunch (On Your Own)
2:30 - 5:00 pmPoster Presentation: Breast/GYN, Lung Collaborative Groups (Poster Highlights from 3:30-4:30 pm)
5:00 - 7:00 pmDinner (On Your Own)
7:00 - 10:00 pmSession III: Molecular Approaches to Screening: Global and Organelle-Based Approaches Co-chairs:
John Semmes, PhD, Eastern Virginia Medical School
Bill Grizzle, MD, PhD, University of Alabama at Birmingham
Jacob Kagan, PhD, National Cancer Institute

Presentations:
Molecular Approaches to Screening
Christine Wu, PhD, The Scripps Research Institute
Genomic Global Profiling
Joe Gray, PhD, Lawrence Berkeley National Laboratory
Proteomic Global Profiling for Cancer Biomarker Discovery
Samir Hanash, MD, PhD, University of Michigan at Ann Arbor
Organelle-Based Approaches
John Bergeron, PhD, McGill University
The Human Mitochondrial Proteome, Aging and Degenerative Diseases
Bradford W Gibson, PhD, Buck Institute of Age Research
Panel Discussion

Tuesday, June 15, 2004
7:00 - 8:00 amContinental Breakfast
8:00 - 10:20 amSession IV: Analysis of High-Throughput Biologic Data for Prediction and Marker Discovery Co-chairs:
Ziding Feng, PhD, Fred Hutchinson Cancer Research Center
Steven Skates, PhD, Massachusetts General Hospital
Paul Pinsky, PhD, National Cancer Institute

Presentations:
Statistical Issues in the Analysis of High-Throughput Biologic Data
Lisa McShane, PhD, National Cancer Institute
Incorporation of Biologically Relevant Information into High- Throughput Biologic Data Analysis
Zhen Zhang, PhD, Johns Hopkins University School of Medicine
A Specific Example and Proven Benefits
Yudong He, PhD, Rosetta Inpharmatics, Inc
Distinct Genetic Pathways Leading to Melanoma Depending on Anatomic Site and UV Exposure
Jane Fridlyand, PhD, University of California at San Francisco Cancer Center
Panel Discussion
10:20 - 10:30 amBreak
10:30 - 12:30 pmSession V: Biology of Hereditary Cancers: What Impact They Have on Sporadic Tumor Detection? Co-chairs:
Patrice Watson, PhD, Creighton University
David Fishman, MD, New York University School of Medicine
Wendy Wang, PhD, National Cancer Institute

Presentations:
Colon Cancer Families
Jeremy Jass, MD, McGill University
The Genetics of Inherited and Sporatic Breast Cancer: How Understanding Genes Can Help Reduce Risk
Piri Welcsh, PhD, University of Washington
Hereditary Ovary Cancer
Jeff Boyd, PhD, Memorial Sloan-Kettering Cancer Center
Panel Discussion
12:30 - 2:30 pmLunch (On Your Own)
2:30 - 5:00 pmPoster Presentations : GI and GU Collaborative Groups (Poster Highlights from 3:30-4:30 pm)
5:00 - 7:00 pmDinner (On Your Own)
7:00 - 10:00 pmSession VI: Validation of Biomarkers Co-chairs:
Margaret Spitz, MD, MD Anderson Cancer Center
Dean Brenner, MD, University of Michigan at Ann Arbor
Padma Maruvada, PhD, National Cancer Institute

Presentations:
Validation: Definitions, Pitfalls and Approaches
David Ransohoff, MD, University of North Carolina at Chapel Hill
Analytical Validation: SELDI in Prostate
John Semmes, PhD, Eastern Virginia Medical Center & Ziding Feng, PhD, Fred Hutchinson Cancer Research Center
Clinical Validation of a Biomarker: DCP and Hepatocellular Carcinoma
Jorge Marrero, MD, University of Michigan at Ann Arbor
Methylation of Key Genes for Urological Cancers
David Sidransky, MD, Johns Hopkins University School of Medicine
Complementary Use of Rodent Systems and Humans for Discovery and Validation of Biomarkers for Cancer Detection and Risk Assessment: Setting the Stage

Rodent Models:
Modeling Ductal Pancreatic Cancer in Mice
David Tuveson, MD, University of Pennsylvania School of Medicine

Human Models:
Clinical Validation of Epigenetic Events as Biomarkers In Barrett's Esophagus Neoplastic Progression
Stephen Meltzer, MD, University of Maryland School of Medicine
Panel Discussion

Wednesday, June 16, 2004
7:00 - 8:00 amContinental Breakfast
8:00 – 10:05 amSession VIIA: Organ Specific Translational Research Co-chairs:
Dan Cramer, MD, Brigham and Women's Hospital
Bill Bigbee, PhD, University of Pittsburgh Cancer Institute
Paul Wagner, PhD, National Cancer Institute

Presentations:
Proteomics of Lung Cancer
David Carbone, MD, PhD, Vanderbilt-Ingram Cancer Center
The University of Michigan Prostate Cancer Rapid Autopsy Program: Translating Findings to Patient Care
Ken Pienta, MD, University of Michigan at Ann Arbor Somatic Genetic and Epigenetic Alterations in Gastrointestinal Cancer
Manuel Perucho, PhD, The Burnham Institute
10:05 – 10:15 amBreak
10:15 am – 12:30 pmSession VIIB: Organ Specific Translational Research Co-chairs:
Dan Cramer MD, Brigham and Women's Hospital
Bill Bigbee, PhD, University of Pittsburgh Cancer Institute
Paul Wagner, PhD, National Cancer Institute

Presentations:
Translational Research on Breast, Endometrial and Ovarian Cancer: an Epidemiologist's View
Dan Cramer, MD, ScD, Brigham and Women's Hospital
Human Papillomaviruses: from Bench to Countryside
Tom Broker, PhD, University of Alabama at Birmingham
p110 sEGFR as a Serum Biomarker in Breast and Gynecologic Cancers
Nita J Maihle, PhD, Yale School of Medicine
Panel Discussion
12:30 – 2:30 pmLunch (On Your Own)
2:30 – 4:00 pmWrap-Up Discussion
4:00 pmAdjourn


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