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Critical Sulfhydryl Switches, Diet, and Cancer Prevention Workshop
Agenda
Thursday, August 28, 2003
7:30 – 8:00 am
Registration
8:00 – 8:30 am
Opening Remarks
Describing the Challenge
EH Jeffery
University of Illinois
Welcome
P Greenwald
Division of Cancer Prevention
J Milner
Nutritional Sciences Research Group
Session 1: Setting the Scene
8:30 am
Diet and Thiol Biochemistry
DE Brash
Yale School of Medicine
8:50 am
Cysteine/Glutathione Deficiency Disease
L Hertzenberg Stanford University
Session 2: Emerging Technology for the Study of Cellular Sulfhydryls
9:10 am
What Methods Are Available for Clinical Evaluation of Thiol Status?
M Stipanuk
Cornell University
9:30 am
How Can We Evaluate Redox in Whole Cells: State of the Art and Novel Approaches
M Philbert
University of Michigan
9:50 am
Discussion
10:10 – 10:30 am
Break
Session 3: Diet and Thiol Regulation of the Cell Cycle
10:30 am
Do Cancer Cells Have an Aberrant Thiol Status In Vivo That Responds to Diet?
G Buettner
University of Iowa
10:50 am
Does Dietary Cysteine Regulation of the Cell Cycle Provide Clues to Additional Dietary Influences?
D Jones
Emory University
11:10 am
How Do Dietary Alteration in Glutathione and Thioredoxin Levels Affect Cell Cycle?
A Holmgren
Karolinska Institutet
11:30 am
Discussion
12:00 pm
Lunch
Session 4: Site-Specific Modifications of Cell Signaling Proteins by Sulfhydryl Switches
1:00 pm
Can Diet Modify Cell Proliferation Through Sufhydryl Switches on Transcription Factors?
D Gius
National Institutes of Health
1:20 pm
Can Dietary Factors Regulate Activity of Cell Signaling Proteins Through Sulfhydryl Biochemistry?
CA O'Brien
University of Texas
MD Anderson Cancer Center
1:40 pm
How Can Non-Thiol Dietary Components Cause Thiol Regulation of the Cell Cycle?
CS Yang
Rutgers University
2:00 pm
Discussion
Session 5: Future Directions
3:00 – 4:00 pm
Panel and Floor Discussion on Research Needs
E Stadtman
National Institutes of Health
4:00 pm
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