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Critical Sulfhydryl Switches, Diet, and Cancer Prevention Workshop

Agenda

Thursday, August 28, 2003
7:30 – 8:00 amRegistration
8:00 – 8:30 amOpening Remarks
Describing the Challenge
EH Jeffery
University of Illinois

Welcome
P Greenwald
Division of Cancer Prevention
J Milner
Nutritional Sciences Research Group

Session 1: Setting the Scene
8:30 amDiet and Thiol Biochemistry
DE Brash
Yale School of Medicine
8:50 amCysteine/Glutathione Deficiency Disease
L Hertzenberg Stanford University

Session 2: Emerging Technology for the Study of Cellular Sulfhydryls
9:10 amWhat Methods Are Available for Clinical Evaluation of Thiol Status?
M Stipanuk
Cornell University
9:30 amHow Can We Evaluate Redox in Whole Cells: State of the Art and Novel Approaches
M Philbert
University of Michigan
9:50 amDiscussion
10:10 – 10:30 am Break

Session 3: Diet and Thiol Regulation of the Cell Cycle
10:30 amDo Cancer Cells Have an Aberrant Thiol Status In Vivo That Responds to Diet?
G Buettner
University of Iowa
10:50 amDoes Dietary Cysteine Regulation of the Cell Cycle Provide Clues to Additional Dietary Influences?
D Jones
Emory University
11:10 amHow Do Dietary Alteration in Glutathione and Thioredoxin Levels Affect Cell Cycle?
A Holmgren
Karolinska Institutet
11:30 amDiscussion
12:00 pmLunch

Session 4: Site-Specific Modifications of Cell Signaling Proteins by Sulfhydryl Switches
1:00 pmCan Diet Modify Cell Proliferation Through Sufhydryl Switches on Transcription Factors?
D Gius
National Institutes of Health
1:20 pmCan Dietary Factors Regulate Activity of Cell Signaling Proteins Through Sulfhydryl Biochemistry?
CA O'Brien
University of Texas
MD Anderson Cancer Center
1:40 pmHow Can Non-Thiol Dietary Components Cause Thiol Regulation of the Cell Cycle?
CS Yang
Rutgers University
2:00 pmDiscussion

Session 5: Future Directions
3:00 – 4:00 pmPanel and Floor Discussion on Research Needs
E Stadtman
National Institutes of Health
4:00 pmClose


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