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Free Radicals: The Pros and Cons of Antioxidants

Agenda

Thursday, June 26, 2003
8:00 - 8:20 am Greetings and Opening Remarks
DCP Greetings and Introductions
Welcome and Prevention overview remarks
DCTD Welcome and Therapy overview remarks
NCCAM Welcome and overview remarks from complementary and alternative medicine
ODS Welcome and overview remarks on dietary supplements

Harold Seifried
Peter Greenwald
Ellen Feigal
Steve Straus
Paul Coates
8:20 - 8:55 amFree Radicals, Cancer Prevention and Therapy: Oxidants, Antioxidants, and Degenerative Disease Bruce Ames
8:55 - 9:05 amDiscussion
9:05 - 11:30 amSession 1 - Oxidative Stress - Positive and Negative Aspects
Chair: Steve Zeisel, University of North Carolina
(15 minute presentations followed by 5 minutes of discussion)
9:05 - 9:25 amRedox Regulation in Normal and Neoplastic Tissue
Frank Meyskens (UC Irvine, Chao Family Comprehensive Cancer Center)
9:25 - 9:45 amCellular Responses to Oxidative Stress: Signaling for Suicide and Survival
Nikki Holbrook (Yale University)
9:45 - 10:05 amBreak
10:05 - 10:25 amMechanisms of Pro- and Anti-oxidation
Homer S Black (Baylor)
10:25 - 10:45 amIron, Free Radicals and Oxidative Injury
Joe M McCord (University of Colorado Health Sciences Center)
10:45 - 11:05 amOxidative Stress and Human Genetic Variation Ralf Morgenstern (Karolinska Institutet)
11:05 - 11:30 amDiscussion Session 1
11:30 - 12:30 amLunch
12:30 - 2:00 pmSession 2 - Antioxidant Effects Pros and Cons
Chair: Richard Rivlin, IFCP

(15 minute presentations followed by 5 minutes of discussion)
12:30 - 12:50 pmPhytochemical Effects Beyond Antioxidation David Heber (UCLA)
12:50 - 1:10 pmTumor Suppressing Effects of Antioxidants
Roderick Dashwood (Linus Pauling Institute - Oregon State University)
1:10 - 1:20 pmAntioxidants Suppress Apoptosis
Steve Zeisel (University of North Carolina)
1:20 - 1:40 pmMechanisms of action of tea polyphenols
CS Yang (Rutgers)
1:40 - 2:00 pmAntioxidants Enhance the Effect of Radiation and Chemotherapeutic Agents on Cancer Cells
Kedar Prasad (University of Colorado Health Sciences Center)
2:00 - 2:20 pmDiscussion Session 2
2:20 - 2:40 pmBreak
2:40 - 5:00 pmSession 3 - Biomarkers
Chair: Steve Clinton, Ohio State University
(15 minute presentation followed by 5 minutes of discussion)
2:40 - 3:00 pmBiomarkers: Fact and Artifact
James Swenberg (University of North Carolina)
3:00 - 3:20 pmPlasma Antioxidant Measurements
Ronald Prior (Arkansas Human Nutrition Center)
3:20 - 3:40 pmDNA Oxidation Products
Henry Thompson (Colorado State University)
3:40 - 4:00 pmUse of Biomarkers of Oxidative Stress in Research Studies
Jeffrey Blumberg (Tufts)
4:00 - 4:20 pmAntioxidant Enzymes - Genetic Variation
Daret St Clair (University of Kentucky)
4:20 - 5:00 pmDiscussion Session 3
5:30 - 9:00 pmReception (Bethesda Marriott, Pooks Hill) (Poster Session)

Friday, June 27, 2003
8:00 - 9:40 amSession 4 - Clinical Aspects of Antioxidant Usage
Chair: Rebecca Costello, ODS
(15 minute presentations followed by 5 minutes of discussions)
8:00 - 8:20 amConsumer Perspectives About Antioxidants
Cheryl Toner (IFIC)
8:20 - 8:40 amWhat Patients Are Asking About Supplements
Cheryl Rock, (UCSD)
8:40 - 9:00 amEfficacy of Dietary Antioxidants to Prevent Oxidative Damage
Balz Frei (Linus Pauling Institute - Oregon State University)
9:00 - 9:20 amBiomarkers for Assessing Intakes of Antioxidant Nutrients
Susan T Mayne (Yale University)
9:20 - 9:40 amDiscussion Session 4
9:40 - 11:30 amSession 5a - Chemotherapy - Antioxidant Interactions
Chair: David S Rosenthal, Harvard
(15 minute presenations followed by 5 minutes of discussions)
9:40 - 10:10 amChemotherapy, Free Radicals and Cancer: An Overview
Kenneth Conklin (UCLA)
10:10 - 10:30 amVitamin C, Oxidative Stress, and Cancer Therapy
David Golde (MSKCC)
10:30 - 10:50 amBreak
10:50 - 11:10 amDrugs, Glutathione and ROS in Regulation of Proliferation
Kenneth D Tew (Fox Chase)
11:10 - 11:30 amDiscussion Session 5
11:30 - 12:50 pmSession 5b - Radiotherapy - Antioxidant Interactions
Chair: Norman Coleman, NCI
(15 minute presentations followed by 5 minutes of discussion)
11:30 - 11:50 pmRadiotherapy, Free Radicals and Cancer
Carmia Borek (Tufts)
11:50 - 12:10 pmNovel Functional Imaging for Tissue Oxygen Concentration and Redox Status
James Mitchell (NCI)
12:10 - 12:30 pmProstate Cancer Therapy and Biomarkers
William Nelson (Johns Hopkins)
12:30 - 1:30 pmLunch
1:30 - 1:50 pmRedox Sensitive Signaling Factors and Antioxidants: How Tumor Cells Response to Ionizing Radiation
David Gius (NCI)
1:50 - 2:10 pmDiscussion Session 5
2:10 - 3:30 pmSession 6 - Wrap-up/Summary, Opportunities and Challenges
Chair: John Milner
Panel Members: Drs Clinton, Zeisel, Rivlin, Rosenthal


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