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Exfoliated Cells, Bioactive Food Components and Cancer Prevention


Friday, May 23, 2003
8:00 amRegistration
8:15 - 8:20 amIntroduction and PurposeC Davis, NSRG
8:20 - 8:25 amWelcomeP Greenwald, DCP
8:25 - 8:30 amWelcomeJ Milner, NSRG
Overview Speakers:
8:30 - 8:55 amBioactive food components in cancer prevention: limitations of serum concentrations as a predictor of response. R. Rivlin
Am. Health Foundation
8:55 - 9:20 amMolecular pathologies in exfoliated cells: Applications in clinical prevention.D Ahlquist
Mayo Clinic
Session I: What are the practical issues regarding the collection of exfoliated cells: yield, quality of cells, difficulty in obtaining samples?
9:20 - 9:45 amDetecting gene mutations from exfoliated lung epithelial cells obtained in sputum or from bronchioalveolar lavage fluid.S Ahrendt
University of Rochester
9:45 - 10:10 amPredicting breast cancer risk by mammaryepithelium sampling techniques. S Khan
Northwestern Memorial Hospital
10:10 - 10:30 amDiscussion Session I
10:30 - 10:45 amBreak
Session II: What have we learned from studies with exfoliated cells?
10:45 - 11:05 amBiomarkers that are being analyzed from nipple aspirate fluid and ductal lavage in cancer chemoprevention trials. S Prindiville
11:05 - 11:25 amDynamics of carotenoid turnover in exfoliated colonic epithelial cells P Nair
Johns Hopkins University
11:25 - 11:50 amChanges in gene expression in exfoliated cells: role of bioactive food components.R Chapkin
Texas A & M University
11:50 am - 12:10 pmCytologic and methylation changes in exfoliated bronchial cells predict lung cancer, but why?T Byers
University of Colorado
12:10 - 12:30 pmDiscussion Session II
12:30 - 1:15 pmLunch
Session III: Are dietary induced changes in biomarkers that are measured in exfoliated cells indicative of changes in target tissues or are they representative of global changes within the body?
1:15 - 1:35 pmTissue specificity: comparison of lycopene accumulation and DNA damage in exfoliated human lung epithelial cells and lymphocytes. S Steck Stock
University of North Carolina
1:35 - 1:55 pmRelationship between DNA methylation in exfoliated cells and target tissues C Piyathilake
University of Alabama
1:55 - 2:15 pmEffect of dietary components on micronuclei formation in exfoliated cells. J Mumford
EPA, North Carolina
2:15 - 2:40 pmDiscussion Session III
2:40 - 2:55 pmBreak
2:55 - 3:45 pmFuture Directions: Setting research priorities in the utilization of exfoliated cells in nutrition and cancer studies C Davis
3:45 pmAdjourn

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