The goal of his laboratory is to develop a strategy for regenerating cardiovascular diseases using stem cells and tissue engineering technologies. Dr. Yoon’s laboratory has focused on generating stem or progenitor cells including induced pluripotent stem cells, multipotent bone marrow cells, and angio-vasculogenic cells, and developing various methods to differentiate these cells into endothelial cells and cardiomyocytes. His laboratory investigates their therapeutic utility in cardiovascular diseases such as peripheral vascular disease including diabetic complications, myocardial infarction, lymphedema and diabetic neuropathy. Mechanistically, the research focuses on angiogenesis, vasculogenesis, lymphangiogenesis and cardiomyogenesis. Recently, his research is extended into reprogramming of somatic cells into target cells and restoring the function of damaged stem or progenitor cells by epigenetic modifications.
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