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Trans-NIH Angiogenesis Workshop; May 20-21, 2013
  • Speaker Biosketches

    Portrait of Steven J. Mentzer, MD

    Steven J. Mentzer, MD
    (Harvard Medical School, Boston, MA)

    Dr. Steven J. Mentzer is Professor of Surgery at Harvard Medical School. As a junior resident at Children's Hospital in Boston, Dr. Judah Folkman introduced him to the role of angiogenesis in wound healing and tumor growth–an association that led to several translational studies and a career-long interest in angiogenesis. Dr. Mentzer's subsequent post-doctoral fellowships in Immunobiology (with Dr. Steven Burakoff) studied lymphocyte migration including the functional biomolecular interactions involved in lymphocyte-endothelial cell interactions. Although primarily focused on the in vitro interactions of β1 and β2 integrins and their ligands, this work led to in vivo studies of lymphocyte recirculation and the membrane molecules potentially involved in lymphocyte "homing" to areas of inflammation; however, lymphocyte "homing" proved to be more a consequence of the microhemodynamic and microstructural features of inflammatory vessels, than a particular "homing" ligand. Among the findings were microangiectasias; namely, focal dilatations of the microcirculation that facilitate lymphocyte adhesion and transmigration. Microangiectasias were spatially and temporally associated with vessels that appeared to be undergoing active luminal division—a process subsequently identified as intussusceptive angiogenesis. Since 2003, Dr. Mentzer has participated in a multi-disciplinary research group (Konerding, Tsuda and Secomb Laboratories) studying intussusceptive angiogenesis. The group has used a variety of imaging, computational and molecular techniques to study intussusceptive angiogenesis in development, inflammation and tissue regeneration ( Clinically, Dr. Mentzer has had leadership roles in lung transplantation and thoracic intensive care at Brigham and Women's Hospital; he is also active participant in clinical and translational studies at the Dana-Farber Cancer Institute.

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Workshop Organizer: NIH

NCI:Nancy Emenaker, PhD, RD
Suzanne Forry-Schaudies, PhD
NHLBI: Yunling Gao, MD, PhD
NIDDK: Teresa Jones, MD

NIH - National Institutes of Health: Turning Discovery Into Health

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