Dr. John Condeelis has devised optical microscopes for uncaging, biosensor detection and multiphoton imaging for these studies and has used novel caged-enzymes and biosensors to test, in vivo, the predictions of the invasion signatures regarding the mechanisms of tumor cell dissemination and metastasis. This work has supplied markers for the prediction of breast tumor metastasis in humans. Three of these markers, TMEM, MenaCalc and cofilin x p-cofilin, have been used in retrospective studies of cohorts of breast cancer patients to predict metastatic risk and are now in clinical validation trials. He has authored more than 250 scientific papers on various aspects of cell and cancer biology, biophysics and optical imaging.
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