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Trans-NIH Angiogenesis Workshop; May 20-21, 2013
  • Abstracts

    Physical Activity, Cell Signaling, and Tumor Vascularity

    Henry J. Thompson, PhD  [ View bio ]
    (Colorado State University)

    Physical activity (PA) is distinct from exercise in that it does not have the goal of improving fitness. Using voluntary wheel running as a model for PA, the effects of PA on chemically induced mammary carcinogenesis have been investigated and protection has been demonstrated. The intent of this presentation is to discuss the effects of PA on tumor vascularization and on the signaling networks operative within mammary carcinomas and how they are impacted relative to tumor perfusion. Both host systemic and cell autonomous mechanisms will be considered. Evidence will also be reported on the potential effects of heritable difference in intrinsic aerobic capacity on the carcinogenic response and whether these genetic differences impact vascularization and perfusion within chemically-induced mammary carcinomas. Rats with low intrinsic aerobic capacity are resistant to exercising on a treadmill; whereas, rats with high intrinsic aerobic activity have a runner’s phenotype. However, in the work reported, all rats remained sedentary throughout the experiment. Evidence will show a previously unappreciated heritable effect on carcinogenesis and tumor vascularization which may have implications for the prevention and control of cancer by physical activity.

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Workshop Organizer: NIH

NCI:Nancy Emenaker, PhD, RD
Suzanne Forry-Schaudies, PhD
NHLBI:Yunling Gao, MD, PhD
NIDDK: Teresa Jones, MD

NIH - National Institutes of Health: Turning Discovery Into Health


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