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Trans-NIH Angiogenesis Workshop; May 20-21, 2013
  • Abstracts

    Imaging angiogenesis and vessel pattern formation: physiological vs pathological vascularities

    Moritz A. Konerding, MD  [ View bio ]
    (Johannes Gutenberg University of Mainz, Rhineland Palatinate, Germany)

    All organs and tissues develop a highly specific vascular architecture fulfilling the individual specific demands. Therefore, the microvascular unit, characterized by inter-vessel distances or vessel density, inter-branch distances, branching angles, and vessel diameters shows significant differences in different tissues. Scanning electron microscopy of microvascular corrosion casts allows for detailed morphometric analysis of these parameters in normal and pathological tissues as well as in embryogenesis. Also the impact of individual pro- or anti-angiogenic factors on the vascular architecture and on sprouting and non-sprouting angiogenesis may be assessed. In xenografted and in human primary tumors we demonstrated a tumor type specific vascularity, which was altered by anti-angiogenic treatment with soluble KDR/VEGF-RII antagonists to limited extents. In studies with cell lines expressing and releasing FGF-II to different extents it has been shown that the vascular architecture is primarily determined by the cells themselves. Modulations of endogenous factors may result in significant changes of the vascularity. TIE-I deficient knock-out mice mutants display significant higher vascular densities during ocular development. Transgenic mice over-expressing VEGF-A164, A-120, or A188 show severe disturbances of the hyaloidal and retinal vascularity. From an embryological point of view ocular angiogenesis is different in some aspects from that of other tissues. Contrary to CNS or other parynchemous organs, different vascular systems have to be established, whereby the hyaloidal system undergoes dramatic changes. On principle, all features of sprouting and non-sprouting, intussusceptive angiogenesis may be seen both in physiological angiogenesis like during normal growth, repair, and wound healing, as well as in pathological conditions like chronic inflammation and tumor growth and metastasation. However, major differences can be seen with regard to vessel remodeling in hierarchisation.

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Workshop Organizer: NIH

NCI:Nancy Emenaker, PhD, RD
Suzanne Forry-Schaudies, PhD
NHLBI:Yunling Gao, MD, PhD
NIDDK: Teresa Jones, MD

NIH - National Institutes of Health: Turning Discovery Into Health


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