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Trans-NIH Angiogenesis Workshop; May 20-21, 2013
  • Abstracts

    Epigenetics in Angiogenesis

    James Herman, MD  [ View bio ]
    (Johns Hopkins Medical Institutions)

    Epigenetic is defined as heritable changes in gene expression not caused by difference in nucleotide sequence or genetic alteration. In the absence of disease, epigenetic changes define different cellular phenotype of tissues, allowing cells to perform differing functions necessary for the function of these tissues and organs. While some disease states are associated with alterations of genetic sequence, for example cancer, in many diseases, sequence alterations cannot explain disease associated phenotypic variation. Even in cancer, the mutational changes can only be linked to some phenotypic variation, and much of the functional differences in this disease, as well as differences between individual cancers, is attributable to epigenetic alterations. Angiogenesis is subject to this generalized program for cellular differentiation, both in the normal formation of blood vessels, as well as alterations that can occur during abnormal blood vessel development. This talk will address the mechanisms of epigenetic regulation, both from a normal developmental perspective, as well as the abnormalities which may lead to disease states.

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Workshop Organizer: NIH

NCI:Nancy Emenaker, PhD, RD
Suzanne Forry-Schaudies, PhD
NHLBI:Yunling Gao, MD, PhD
NIDDK: Teresa Jones, MD

NIH - National Institutes of Health: Turning Discovery Into Health

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