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Trans-NIH Angiogenesis Workshop; May 20-21, 2013
  • Abstracts

    Role of the microenvironment in VEGF-dependent and
    -independent angiogenesis

    Napoleone Ferrara, MD  [ View bio ]
    (University of California, San Diego)

    Vascular endothelial growth factor (VEGF)-A is a key regulator of growth of blood vessels during embryonic development and in a variety of physiological processes. Multiple VEGF inhibitors have been shown to block tumor growth and neovascularization in numerous preclinical models, consistent with an important role of VEGF-A in tumor angiogenesis. A humanized anti-VEGF-A monoclonal antibody and several small molecule VEGF receptor kinase inhibitors have been approved for therapy of multiple tumor types. Over the last few years, we have been investigating the mechanisms of inherent refractoriness or acquired resistance to anti-VEGF therapies in tumor models. These studies indicate that multiple pro-angiogenic mechanisms may be implicated. Factors produced by tumor-infiltrating myeloid cells or by fibroblasts were identified as key mediators of VEGF-independent angiogenesis. Efforts are ongoing to determine the therapeutical significance of such findings.

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Workshop Organizer: NIH

NCI:Nancy Emenaker, PhD, RD
Suzanne Forry-Schaudies, PhD
NHLBI:Yunling Gao, MD, PhD
NIDDK: Teresa Jones, MD

NIH - National Institutes of Health: Turning Discovery Into Health


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