Dr. Stuart Baker develops and applies statistical methods to biological and clinical topics and also writes commentaries on theories of carcinogenesis. He introduced the following:
(1) The concept of "paradigm instability," based on a buried treasure analogy, for discussing theories of carcinogenesis (Baker et. al. 2010, Baker 2012).
(2) The paired availability design for historical controls, which adjusts for different availabilities of treatment in different centers. The underlying principal stratification model was independently developed by Permutt and Hebel (1989), Baker and Lindeman (1994), Angrist, Imbens, and Rubin (1996), and Cuzick et. al. (1997).
(3) Relative utility curves and test tradeoff for evaluating risk prediction based on decision analysis (Baker et al 2009, 2012).
(4) The BK-Plot for illustrating mixtures of probabilities. The original application to Simpson’s paradox was independently developed by Jeon et. al. (1987) and Baker and Kramer (2001).
(5) Swirls and Ripples, a method for high dimensional classification that can include “islands” of one class within another class as well as usual boundaries (Baker, 2010).
(6) The standard error multiplier for evaluating surrogate endpoints based on historical trials (Baker et. al. 2012).
(7) A biomarker pipeline to develop and evaluate cancer screening tests (Baker 2009).
(8) A likelihood-based approach for the analysis of twin data (Baker et. al. 2005).
Dr. Baker was the first recipient of the distinguished alum award from the Department of Biostatistics at the Harvard School of Public Health. He is also a fellow of the American Statistical Association.
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